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O51273 (UPPP_BORBU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA, upk
Ordered Locus Names:BB_0258
OrganismBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680) [Reference proteome] [HAMAP]
Taxonomic identifier224326 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group

Protein attributes

Sequence length266 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 266266Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000151114

Regions

Transmembrane4 – 2421Helical; Potential
Transmembrane39 – 5921Helical; Potential
Transmembrane86 – 10621Helical; Potential
Transmembrane112 – 13221Helical; Potential
Transmembrane145 – 16521Helical; Potential
Transmembrane182 – 20221Helical; Potential
Transmembrane210 – 23021Helical; Potential
Transmembrane246 – 26621Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
O51273 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: FD08CAB7EE4CD9C5

FASTA26630,271
        10         20         30         40         50         60 
MTNILSAIIL GIIQGITEFL PISSSGHLLL FRHFINLKLS IIFDIYLHLA TVLVIIIYYR 

        70         80         90        100        110        120 
KRILELFLTF IRFSLRKTVK SDLTNLKLIL LILIITIVTG VVGTFISKYE SMFTLSFVLI 

       130        140        150        160        170        180 
NFIITGILIL MLEFNFLKVD FKGNILLAGI FMGLMQGLGA LPGISRSGIT IFSASVIGFN 

       190        200        210        220        230        240 
RKSAFEISFL SLIPIVFGAI LLKHKEFYDI FMVLNFFEIN LGALVAFVVG IFSINFFFKM 

       250        260 
LNNKKLYYFS IYLFALSIIV CYFVRI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000783 Genomic DNA. Translation: AAC66636.1.
PIRB70132.
RefSeqNP_212392.1. NC_001318.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224326.BB0258.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC66636; AAC66636; BB_0258.
GeneID1195095.
KEGGbbu:BB_0258.
PATRIC20557134. VBIBorBur75917_0657.

Phylogenomic databases

eggNOGCOG1968.
KOK06153.
OMAAQCFALI.
OrthoDBEOG6QP13M.
ProtClustDBPRK00281.

Enzyme and pathway databases

BioCycBBUR224326:G9SO-258-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_BORBU
AccessionPrimary (citable) accession number: O51273
Entry history
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: June 1, 1998
Last modified: February 19, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families