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O51273

- UPPP_BORBU

UniProt

O51273 - UPPP_BORBU

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciBBUR224326:G9SO-258-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Synonyms:bacA, upk
    Ordered Locus Names:BB_0258
    OrganismiBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
    Taxonomic identifieri224326 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group
    ProteomesiUP000001807: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 266266Undecaprenyl-diphosphatasePRO_0000151114Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi224326.BB0258.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei4 – 2421HelicalUniRule annotationAdd
    BLAST
    Transmembranei39 – 5921HelicalUniRule annotationAdd
    BLAST
    Transmembranei86 – 10621HelicalUniRule annotationAdd
    BLAST
    Transmembranei112 – 13221HelicalUniRule annotationAdd
    BLAST
    Transmembranei145 – 16521HelicalUniRule annotationAdd
    BLAST
    Transmembranei182 – 20221HelicalUniRule annotationAdd
    BLAST
    Transmembranei210 – 23021HelicalUniRule annotationAdd
    BLAST
    Transmembranei246 – 26621HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    KOiK06153.
    OMAiFNDAHAK.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O51273-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTNILSAIIL GIIQGITEFL PISSSGHLLL FRHFINLKLS IIFDIYLHLA    50
    TVLVIIIYYR KRILELFLTF IRFSLRKTVK SDLTNLKLIL LILIITIVTG 100
    VVGTFISKYE SMFTLSFVLI NFIITGILIL MLEFNFLKVD FKGNILLAGI 150
    FMGLMQGLGA LPGISRSGIT IFSASVIGFN RKSAFEISFL SLIPIVFGAI 200
    LLKHKEFYDI FMVLNFFEIN LGALVAFVVG IFSINFFFKM LNNKKLYYFS 250
    IYLFALSIIV CYFVRI 266
    Length:266
    Mass (Da):30,271
    Last modified:June 1, 1998 - v1
    Checksum:iFD08CAB7EE4CD9C5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000783 Genomic DNA. Translation: AAC66636.1.
    PIRiB70132.
    RefSeqiNP_212392.1. NC_001318.1.

    Genome annotation databases

    EnsemblBacteriaiAAC66636; AAC66636; BB_0258.
    GeneIDi1195095.
    KEGGibbu:BB_0258.
    PATRICi20557134. VBIBorBur75917_0657.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000783 Genomic DNA. Translation: AAC66636.1 .
    PIRi B70132.
    RefSeqi NP_212392.1. NC_001318.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224326.BB0258.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC66636 ; AAC66636 ; BB_0258 .
    GeneIDi 1195095.
    KEGGi bbu:BB_0258.
    PATRICi 20557134. VBIBorBur75917_0657.

    Phylogenomic databases

    eggNOGi COG1968.
    KOi K06153.
    OMAi FNDAHAK.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci BBUR224326:G9SO-258-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.

    Entry informationi

    Entry nameiUPPP_BORBU
    AccessioniPrimary (citable) accession number: O51273
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 5, 2002
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3