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O51273

- UPPP_BORBU

UniProt

O51273 - UPPP_BORBU

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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. dephosphorylation Source: InterPro
  3. peptidoglycan biosynthetic process Source: UniProtKB-KW
  4. regulation of cell shape Source: UniProtKB-KW
  5. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciBBUR224326:G9SO-258-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Synonyms:bacA, upk
Ordered Locus Names:BB_0258
OrganismiBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Taxonomic identifieri224326 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group
ProteomesiUP000001807: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4 – 2421HelicalUniRule annotationAdd
BLAST
Transmembranei39 – 5921HelicalUniRule annotationAdd
BLAST
Transmembranei86 – 10621HelicalUniRule annotationAdd
BLAST
Transmembranei112 – 13221HelicalUniRule annotationAdd
BLAST
Transmembranei145 – 16521HelicalUniRule annotationAdd
BLAST
Transmembranei182 – 20221HelicalUniRule annotationAdd
BLAST
Transmembranei210 – 23021HelicalUniRule annotationAdd
BLAST
Transmembranei246 – 26621HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 266266Undecaprenyl-diphosphatasePRO_0000151114Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224326.BB0258.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
KOiK06153.
OMAiFNDAHAK.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

O51273-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTNILSAIIL GIIQGITEFL PISSSGHLLL FRHFINLKLS IIFDIYLHLA
60 70 80 90 100
TVLVIIIYYR KRILELFLTF IRFSLRKTVK SDLTNLKLIL LILIITIVTG
110 120 130 140 150
VVGTFISKYE SMFTLSFVLI NFIITGILIL MLEFNFLKVD FKGNILLAGI
160 170 180 190 200
FMGLMQGLGA LPGISRSGIT IFSASVIGFN RKSAFEISFL SLIPIVFGAI
210 220 230 240 250
LLKHKEFYDI FMVLNFFEIN LGALVAFVVG IFSINFFFKM LNNKKLYYFS
260
IYLFALSIIV CYFVRI
Length:266
Mass (Da):30,271
Last modified:June 1, 1998 - v1
Checksum:iFD08CAB7EE4CD9C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000783 Genomic DNA. Translation: AAC66636.1.
PIRiB70132.
RefSeqiNP_212392.1. NC_001318.1.

Genome annotation databases

EnsemblBacteriaiAAC66636; AAC66636; BB_0258.
GeneIDi1195095.
KEGGibbu:BB_0258.
PATRICi20557134. VBIBorBur75917_0657.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000783 Genomic DNA. Translation: AAC66636.1 .
PIRi B70132.
RefSeqi NP_212392.1. NC_001318.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224326.BB0258.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC66636 ; AAC66636 ; BB_0258 .
GeneIDi 1195095.
KEGGi bbu:BB_0258.
PATRICi 20557134. VBIBorBur75917_0657.

Phylogenomic databases

eggNOGi COG1968.
KOi K06153.
OMAi FNDAHAK.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci BBUR224326:G9SO-258-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.

Entry informationi

Entry nameiUPPP_BORBU
AccessioniPrimary (citable) accession number: O51273
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: June 1, 1998
Last modified: October 29, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3