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O51267

- SYL_BORBU

UniProt

O51267 - SYL_BORBU

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Protein

Leucine--tRNA ligase

Gene
leuS, BB_0251
Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei620 – 6201ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBBUR224326:G9SO-251-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:BB_0251
OrganismiBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Taxonomic identifieri224326 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group
ProteomesiUP000001807: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 840840Leucine--tRNA ligaseUniRule annotationPRO_0000151983Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224326.BB0251.

Structurei

3D structure databases

ProteinModelPortaliO51267.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi44 – 5512"HIGH" regionUniRule annotationAdd
BLAST
Motifi617 – 6215"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O51267-1 [UniParc]FASTAAdd to Basket

« Hide

MSKYEFIKIE KKWQEFWDNN KTYKVEEDPS IPKEKRLYIL DMFPYPSANG    50
LHVGHPEGYT ATDIFGRYKL LNGFHVLHPI GFDSFGLPAE NYAIQTGTHP 100
QKSTEENINK FKKQIKALGF AYDWDREIRT HEENYYKWTQ WIFLQLYKKG 150
LAYVKEMPVW YCPELGTVLA NEEIIQTSDG PKSERGSYSV EKKYLRQWVL 200
KITKYAERLL DDLEELEWPE SVKEMQRNWI GKSTGVEIEF EIEGHSDKIK 250
VFTTRPDTIF GITYLVIAPE NKLIEKITKN NFKQNVLKYV KHEELKSDLN 300
RTSLEKDKSG VFTGSYAFHP ITNEKIPIWV GSYVLGTYGT GAVMGVPAHD 350
ERDFQFAKKY QLKILPVISK SGKNEILEKA FVDDGISINS PNEFNNLKNS 400
EVKDKVIKWL TKNKKGKEKV AYKLRDWIFS RQRYWGEPIP ILFDKLGNAI 450
PLEENDLPLK LPEIANYKPS GTGESPLSRI KDWVNVKDMG FTRETNTMPQ 500
WAGSCWYYLR YLDPKNSKEF ANKKKIEYWM PVDLYIGGAE HTVLHLLYSR 550
FWHKVLYDLG YVNTKEPFKK LINQGIITSF SYQKENGVLI PNDQVIEKDN 600
KFFDKKDNKE VTQVIAKMSK SLKNVINPDD IIKEFGADSM RIYEMFMGPL 650
TDSKPWNTKG IIGVFRFLNK IWNLREKELS KENPPREIIS ELHKVIKKVT 700
EDTEKLNFNT AISAMMIFIN ELLKYEKNYL NIFKPFIIIL SPYAPHLAEE 750
LWEYIGELPS LFKNSKWPKF DESLIIKGKK EIVLQINGKI KDKILLNKET 800
GEKELKEIAM ENSKIKSNLL NKKIVKIIVI KNKLVNIVIK 840
Length:840
Mass (Da):98,158
Last modified:June 1, 1998 - v1
Checksum:i521C76BAF009593E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000783 Genomic DNA. Translation: AAB91495.1.
PIRiC70131.
RefSeqiNP_212385.1. NC_001318.1.
WP_010889717.1. NC_001318.1.

Genome annotation databases

EnsemblBacteriaiAAB91495; AAB91495; BB_0251.
GeneIDi1195088.
KEGGibbu:BB_0251.
PATRICi20557120. VBIBorBur75917_0650.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000783 Genomic DNA. Translation: AAB91495.1 .
PIRi C70131.
RefSeqi NP_212385.1. NC_001318.1.
WP_010889717.1. NC_001318.1.

3D structure databases

ProteinModelPortali O51267.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224326.BB0251.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB91495 ; AAB91495 ; BB_0251 .
GeneIDi 1195088.
KEGGi bbu:BB_0251.
PATRICi 20557120. VBIBorBur75917_0650.

Phylogenomic databases

eggNOGi COG0495.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci BBUR224326:G9SO-251-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.

Entry informationi

Entry nameiSYL_BORBU
AccessioniPrimary (citable) accession number: O51267
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: September 3, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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