Reviewed, UniProtKB/Swiss-Prot O51263 (NTPA_BORBU)

Names and origin

Protein names

Recommended name:
    Nucleoside-triphosphatase
    EC=3.6.1.15
Alternative name(s):
    Nucleoside triphosphate phosphohydrolase
      Short name=NTPase

Gene names

Ordered Locus Names:

BB_0247

Organism

Borrelia burgdorferi (Lyme disease spirochete) [Complete proteome] [HAMAP]

Taxonomic identifier

139 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group

Protein attributes

Sequence length	201 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions By similarity. HAMAP MF_01405
Catalytic activity	NTP + H2O = NDP + phosphate. HAMAP MF_01405
Cofactor	Divalent cations By similarity. HAMAP MF_01405
Subunit structure	Homodimer By similarity. HAMAP MF_01405
Sequence similarities	Belongs to the HAM1 NTPase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	nucleoside-triphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 201	201	Nucleoside-triphosphatase HAMAP MF_01405		PRO_0000178136

Sequences

	Sequence		Length	Mass (Da)
	O51263-1 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 199E43E0704B4575	FASTA	201	23,138
	10 20 30 40 50 60 MKTLFFATTN ENKINEVKNI LDIPNLNLIV PQNFNIKETG KTFKENSLLK AKALFEILNN 70 80 90 100 110 120 NQNVFGEDSG LCIEALNLEP GIYSKRYDTY KLCKKLSTNE KNQLILDLMK NEKNRKAYFI 130 140 150 160 170 180 CNISYISKNG QILNFEGIIK GKIALSLNDK KNYGFGYDSI FLTKNNKKLS DLTLEEKNKI 190 200 SHRGIAFLKF KKFLLKSLFN S

References

[1]

"Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi." Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A., Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K., Gwinn M.L., Dougherty B.A., Tomb J.-F., Fleischmann R.D., Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J. , Salzberg S.L., Hanson M., van Vugt R., Palmer N., Adams M.D., Gocayne J.D., Weidman J.F., Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C., Garland S.A., Fujii C., Cotton M.D., Horst K., Roberts K.M., Hatch B., Smith H.O., Venter J.C. Nature 390:580-586(1997) [PubMed: 9403685] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000783 Genomic DNA. Translation: AAB91499.1.
PIR	G70130.
RefSeq	NP_212381.1.
3D structure databases
SMR	O51263. Positions 3-197.
ModBase	Search...
Genome annotation databases
GeneID	1195084.
GenomeReviews	Gene locus BB_0247 in contig AE000783_GR.
KEGG	bbu:BB0247.
NMPDR	fig|224326.1.peg.631.
TIGR	BB_0247.
Phylogenomic databases
HOGENOM	HBG697237.
OMA	FAYDSIF.
PhylomeDB	O51263.
Enzyme and pathway databases
BioCyc	BBUR224326:BB_0247-MONOMER.
BRENDA	3.6.1.15. 142596.
Family and domain databases
HAMAP	MF_01405. Nucleoside_triphosp. [Tree]
InterPro	IPR002637. Ham1p-like. IPR020922. Nucleoside-triphosphatase. [Graphical view]
PANTHER	PTHR11067. Ham1p_like. 1 hit.
Pfam	PF01725. Ham1p_like. 1 hit. [Graphical view]
TIGRFAMs	TIGR00042. Ham1p_like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NTPA_BORBU

Accession

Primary (citable) accession number: O51263

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2002
Last sequence update:	June 1, 1998
Last modified:	February 9, 2010
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)