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Protein

6-phosphogluconolactonase

Gene

pgl

Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

Pathway: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (zwf)
  2. 6-phosphogluconolactonase (pgl)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (gnd)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciBBUR224326:G9SO-222-MONOMER.
UniPathwayiUPA00115; UER00409.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconolactonase (EC:3.1.1.31)
Short name:
6PGL
Gene namesi
Name:pgl
Synonyms:devB
Ordered Locus Names:BB_0222
OrganismiBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Taxonomic identifieri224326 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesBorreliaceaeBorreliaBorrelia burgdorferi group
ProteomesiUP000001807 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2352356-phosphogluconolactonasePRO_0000090089Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224326.BB_0222.

Structurei

3D structure databases

ProteinModelPortaliO51240.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0363.
KOiK01057.
OMAiFLVDERC.
OrthoDBiEOG63FW46.

Family and domain databases

InterProiIPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O51240-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFLYSDEEN YLKDRFFDFF NMNVDKDKYT SIGICGGRSI VNFLSVFLKQ
60 70 80 90 100
NFSFRRSHFF LVDERCVPLN DENSNYNLLN KNFFSKMVDK NLISISKFHA
110 120 130 140 150
FVYSEIDEAT AIHDYNIEFN SRFNIFDFII VSVGEDGHIA SLFPSRKLLF
160 170 180 190 200
SDVEGYQYEY NSPKFPSKRI SLTPKSLFGS KAVVLLFMGV DKKCALENFL
210 220 230
ASNSSINECP ARLLKEHPNL LVLTNIKRDE SYAGS
Length:235
Mass (Da):27,198
Last modified:June 1, 1998 - v1
Checksum:iA3B16EE42D9E44F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000783 Genomic DNA. Translation: AAC66602.1.
PIRiF70127.
RefSeqiNP_212356.1. NC_001318.1.
WP_002661712.1. NC_001318.1.

Genome annotation databases

EnsemblBacteriaiAAC66602; AAC66602; BB_0222.
GeneIDi1195059.
KEGGibbu:BB_0222.
PATRICi20557058. VBIBorBur75917_0620.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000783 Genomic DNA. Translation: AAC66602.1.
PIRiF70127.
RefSeqiNP_212356.1. NC_001318.1.
WP_002661712.1. NC_001318.1.

3D structure databases

ProteinModelPortaliO51240.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224326.BB_0222.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC66602; AAC66602; BB_0222.
GeneIDi1195059.
KEGGibbu:BB_0222.
PATRICi20557058. VBIBorBur75917_0620.

Phylogenomic databases

eggNOGiCOG0363.
KOiK01057.
OMAiFLVDERC.
OrthoDBiEOG63FW46.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00409.
BioCyciBBUR224326:G9SO-222-MONOMER.

Family and domain databases

InterProiIPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.

Entry informationi

Entry namei6PGL_BORBU
AccessioniPrimary (citable) accession number: O51240
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: June 24, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.