Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O51216

- SPOT_BORBU

UniProt

O51216 - SPOT_BORBU

Protein

Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase

Gene

spoT

Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the degradation of ppGpp into GDP. It may also be capable of catalyzing the synthesis of ppGpp By similarity.By similarity

    Catalytic activityi

    Guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate.

    Cofactori

    Manganese.By similarity

    Pathwayi

    GO - Molecular functioni

    1. guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity Source: UniProtKB-EC
    2. metal ion binding Source: InterPro
    3. phosphoric diester hydrolase activity Source: InterPro

    GO - Biological processi

    1. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Manganese

    Enzyme and pathway databases

    BioCyciBBUR224326:G9SO-194-MONOMER.
    UniPathwayiUPA00908; UER00886.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC:3.1.7.2)
    Alternative name(s):
    Penta-phosphate guanosine-3'-pyrophosphohydrolase
    Short name:
    (ppGpp)ase
    Gene namesi
    Name:spoT
    Ordered Locus Names:BB_0198
    OrganismiBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
    Taxonomic identifieri224326 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group
    ProteomesiUP000001807: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 667667Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolasePRO_0000166568Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi224326.BB0198.

    Structurei

    3D structure databases

    ProteinModelPortaliO51216.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini62 – 161100HDAdd
    BLAST

    Sequence similaritiesi

    Belongs to the RelA/SpoT family.Curated
    Contains 1 HD domain.Curated

    Phylogenomic databases

    eggNOGiCOG0317.
    OMAiTENDAES.
    OrthoDBiEOG6SV551.

    Family and domain databases

    Gene3Di3.10.20.30. 1 hit.
    InterProiIPR012675. Beta-grasp_dom.
    IPR003607. HD/PDEase_dom.
    IPR006674. HD_domain.
    IPR004811. RelA/Spo_fam.
    IPR007685. RelA_SpoT.
    IPR004095. TGS.
    IPR012676. TGS-like.
    [Graphical view]
    PfamiPF01966. HD. 1 hit.
    PF04607. RelA_SpoT. 1 hit.
    PF02824. TGS. 1 hit.
    [Graphical view]
    SMARTiSM00471. HDc. 1 hit.
    SM00954. RelA_SpoT. 1 hit.
    [Graphical view]
    SUPFAMiSSF81271. SSF81271. 1 hit.
    TIGRFAMsiTIGR00691. spoT_relA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O51216-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIQAYEIAHL IKINDLEKAR NIFKKTVENT YKDEFERKSI FKALEIAEQL    50
    HYGQYRESGE PYIIHPIMVS LFLAKFQLDF KATIAGLLHD VLEDTNVEKE 100
    EIVKEFDEEI LSLIDGVTKI HDLHNKTRSI KEANTISKMF FAMTHDIRII 150
    IIKLADKLHN MTTLSYLPKN RQDRIAKDCL STYVPIAERL GISSLKTYLE 200
    DLSFKHLYPK DYKEIKNFLS ETKIEREKKL YKGKLSIEKE LQKSGIEAEI 250
    TVRSKHFYSI FRKMQTRTNK LTQIFDTLGI RIICKKQKEC YEILEIVHRV 300
    WKPIPGRLKD YIASPKENKY QSLHTTVRIP EDNQLIEIQI RTEEMDRIAN 350
    YGVAAHWIYK EQIELKADDL SFINRIKKWQ QESANKSQYS MNDIHKELLN 400
    TFIYVYTPEG EVVELPFGSN SIDFAYIIHT DIGDQALYAK INGKISSITK 450
    PLKNEQIVEI FTSKDSKPDV IWLNSVRTKK ARSKIRSWLN KNDNTIFVDN 500
    NIIAYLVGAN KEQRKLFSLF KSYTKTKIKR IAIDPECSPT TGEDIIGIIH 550
    KDEIIVHNEN CQKLKSYKKP QLIEVEWEAT PTRKVHHIIL LLKELKGIFS 600
    YLENIFTLND VRLISEKIED CGNGHGITNI IVSSNAKNIT KIISALKENP 650
    NILQIMQIEE DIKNYDN 667
    Length:667
    Mass (Da):77,763
    Last modified:June 1, 1998 - v1
    Checksum:i608AE939725E2120
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000783 Genomic DNA. Translation: AAC66590.1.
    PIRiF70124.
    RefSeqiNP_212332.1. NC_001318.1.

    Genome annotation databases

    EnsemblBacteriaiAAC66590; AAC66590; BB_0198.
    GeneIDi1195033.
    KEGGibbu:BB_0198.
    PATRICi20556998. VBIBorBur75917_0594.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000783 Genomic DNA. Translation: AAC66590.1 .
    PIRi F70124.
    RefSeqi NP_212332.1. NC_001318.1.

    3D structure databases

    ProteinModelPortali O51216.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224326.BB0198.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC66590 ; AAC66590 ; BB_0198 .
    GeneIDi 1195033.
    KEGGi bbu:BB_0198.
    PATRICi 20556998. VBIBorBur75917_0594.

    Phylogenomic databases

    eggNOGi COG0317.
    OMAi TENDAES.
    OrthoDBi EOG6SV551.

    Enzyme and pathway databases

    UniPathwayi UPA00908 ; UER00886 .
    BioCyci BBUR224326:G9SO-194-MONOMER.

    Family and domain databases

    Gene3Di 3.10.20.30. 1 hit.
    InterProi IPR012675. Beta-grasp_dom.
    IPR003607. HD/PDEase_dom.
    IPR006674. HD_domain.
    IPR004811. RelA/Spo_fam.
    IPR007685. RelA_SpoT.
    IPR004095. TGS.
    IPR012676. TGS-like.
    [Graphical view ]
    Pfami PF01966. HD. 1 hit.
    PF04607. RelA_SpoT. 1 hit.
    PF02824. TGS. 1 hit.
    [Graphical view ]
    SMARTi SM00471. HDc. 1 hit.
    SM00954. RelA_SpoT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81271. SSF81271. 1 hit.
    TIGRFAMsi TIGR00691. spoT_relA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.

    Entry informationi

    Entry nameiSPOT_BORBU
    AccessioniPrimary (citable) accession number: O51216
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3