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O51182 (ALR_BORBU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Alanine racemase
EC=5.1.1.1
Gene names
Name:alr
Ordered Locus Names:BB_0160
OrganismBorrelia burgdorferi (Lyme disease spirochete)
Taxonomic identifier139 [NCBI]
Taxonomic lineageBacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group

Protein attributes

Sequence length372 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Provides the D-alanine required for cell wall biosynthesis By similarity. HAMAP MF_01201

Catalytic activity

L-alanine = D-alanine. HAMAP MF_01201

Cofactor

Pyridoxal phosphate By similarity. HAMAP MF_01201

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP MF_01201

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_01201

Sequence similarities

Belongs to the alanine racemase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 372372Alanine racemase HAMAP MF_01201
PRO_0000114502

Sites

Active site411Proton acceptor; specific for D-alanine By similarity
Active site2681Proton acceptor; specific for L-alanine By similarity

Amino acid modifications

Modified residue411N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
O51182 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 0E5E8DFD68388DAA

FASTA37243,086
        10         20         30         40         50         60 
MYNNKTMGSN KTIIINLNNL EHNLNLIKNK IGEKEIVATL KGDAYGHGLI NIFKFLKSKN 

        70         80         90        100        110        120 
INYFGLSNIE DAKTLKKIDK NIKILMYIKV DKKEIKNLIK FELVPFVSDF EYLFLIEKEC 

       130        140        150        160        170        180 
ALQKNKIKVH LKIDIGMNRY GIKIDDALEI ATYIQNSKFL ELEGICSHLP SIENFKTTQK 

       190        200        210        220        230        240 
QIEQFLFFLE TLKQKNIHPK FVHISNSGHI INYKLNPQFN MVRPGLILYG YCQSLKNKKP 

       250        260        270        280        290        300 
ALNFKPVLSL FSKVIFIKNV KKGEKISYSG IFQAKEDMKI GIIPIGYFDG IPQNISNDFY 

       310        320        330        340        350        360 
FLINNKKCKI RGKVCMNLTI VEIPKDLKVK TGSKVEIVSE KLSIDEMSKF SKRSHYELLC 

       370 
NIGKYEKRKY LD

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000783 Genomic DNA. Translation: AAC66549.1.
PIRH70119.
RefSeqNP_212294.1. NC_001318.1.

3D structure databases

ProteinModelPortalO51182.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBORT00000008471; EBBORP00000007801; EBBORG00000008470.
GeneID1194995.
GenomeReviewsGene locus BB_0160 in contig AE000783_GR.
KEGGbbu:BB0160.
NMPDRfig|224326.1.peg.544.
PATRIC20556924. VBIBorBur75917_0557.
TIGRBB_0160.

Phylogenomic databases

GeneTreeEBGT00050000007269.
HOGENOMHBG712172.
OMAKKIKVHL.
ProtClustDBCLSK507396.

Enzyme and pathway databases

BioCycBBUR224326:BB_0160-MONOMER.

Family and domain databases

HAMAPMF_01201. Ala_racemase.
[Tree]
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
[Graphical view]
Gene3DG3DSA:2.40.37.10. Ala_racemase/Decarboxylase_C. 1 hit.
KOK01775.
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. Racem_decarbox_C. 1 hit.
TIGRFAMsTIGR00492. Alr. 1 hit.
PROSITEPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALR_BORBU
AccessionPrimary (citable) accession number: O51182
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: January 25, 2012
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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