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O51160

- SYH_BORBU

UniProt

O51160 - SYH_BORBU

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Protein

Histidine--tRNA ligase

Gene

hisS

Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. histidine-tRNA ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. histidyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBBUR224326:G9SO-134-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine--tRNA ligase (EC:6.1.1.21)
Alternative name(s):
Histidyl-tRNA synthetase
Short name:
HisRS
Gene namesi
Name:hisS
Ordered Locus Names:BB_0135
OrganismiBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Taxonomic identifieri224326 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group
ProteomesiUP000001807: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 456456Histidine--tRNA ligasePRO_0000136120Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi224326.BB0135.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0124.
KOiK01892.
OMAiGKQIKFA.

Family and domain databases

Gene3Di3.40.50.800. 1 hit.
HAMAPiMF_00127. His_tRNA_synth.
InterProiIPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
[Graphical view]
PANTHERiPTHR11476. PTHR11476. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
[Graphical view]
PIRSFiPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMiSSF52954. SSF52954. 1 hit.
TIGRFAMsiTIGR00442. hisS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O51160-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDIKTLKGFK DYLPKDSLIR IHIVRQIFSV LNSYNFDLID TPVLEYSDLL
60 70 80 90 100
LKKSGDETEK QIYRFKDNGG RDVSMRFDLT VPFARFVATN ISALKLPFRR
110 120 130 140 150
SQFGKVFRGE NSQKGRYREF MQFDFDIVGE DTFRGDAEIL SVVYYGLEEI
160 170 180 190 200
FLNFIEGINK KFIIHYSHIG ILNSFFEKLG LKEKSIFILR NIDKIDKIGI
210 220 230 240 250
DKVKEALLLE IEKEAVDSIL SLVSLQGTFK DKIQALKSIL GDNESIKRVE
260 270 280 290 300
DVFQHLSLLK IQDSFNLNLK ISRGLDYYTG IVFESEVFGS NMGSVCSGGR
310 320 330 340 350
YDNLVSSFSN SIQKISGVGG SFGVDRIKDI IDLEKFSYIK IFVTKARSKV
360 370 380 390 400
LIVNLDSALQ NYYYELATRF RNHDYSKVKN ISCEVYFKNK NGKNIKEQIE
410 420 430 440 450
YALSKEIRFL VFVGQEEYKE NKMKVRDLTK KEELLLSFEE SINLIKCNEK

LLCTPF
Length:456
Mass (Da):52,718
Last modified:April 18, 2012 - v2
Checksum:i16FF8083798BF319
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000783 Genomic DNA. Translation: AAC66531.2.
PIRiG70116.
RefSeqiNP_212269.2. NC_001318.1.

Genome annotation databases

EnsemblBacteriaiAAC66531; AAC66531; BB_0135.
GeneIDi1194970.
KEGGibbu:BB_0135.
PATRICi20556876. VBIBorBur75917_0533.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000783 Genomic DNA. Translation: AAC66531.2 .
PIRi G70116.
RefSeqi NP_212269.2. NC_001318.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224326.BB0135.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC66531 ; AAC66531 ; BB_0135 .
GeneIDi 1194970.
KEGGi bbu:BB_0135.
PATRICi 20556876. VBIBorBur75917_0533.

Phylogenomic databases

eggNOGi COG0124.
KOi K01892.
OMAi GKQIKFA.

Enzyme and pathway databases

BioCyci BBUR224326:G9SO-134-MONOMER.

Family and domain databases

Gene3Di 3.40.50.800. 1 hit.
HAMAPi MF_00127. His_tRNA_synth.
InterProi IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
[Graphical view ]
PANTHERi PTHR11476. PTHR11476. 1 hit.
Pfami PF03129. HGTP_anticodon. 1 hit.
[Graphical view ]
PIRSFi PIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMi SSF52954. SSF52954. 1 hit.
TIGRFAMsi TIGR00442. hisS. 1 hit.
PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.

Entry informationi

Entry nameiSYH_BORBU
AccessioniPrimary (citable) accession number: O51160
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: April 18, 2012
Last modified: October 29, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3