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Protein

Histidine--tRNA ligase

Gene

hisS

Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBBUR224326:G9SO-134-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine--tRNA ligase (EC:6.1.1.21)
Alternative name(s):
Histidyl-tRNA synthetase
Short name:
HisRS
Gene namesi
Name:hisS
Ordered Locus Names:BB_0135
OrganismiBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Taxonomic identifieri224326 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesBorreliaceaeBorreliaBorrelia burgdorferi group
ProteomesiUP000001807 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 456456Histidine--tRNA ligasePRO_0000136120Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi224326.BB_0135.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0124.
KOiK01892.
OMAiFMATNKS.

Family and domain databases

Gene3Di3.40.50.800. 1 hit.
HAMAPiMF_00127. His_tRNA_synth.
InterProiIPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
[Graphical view]
PANTHERiPTHR11476. PTHR11476. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
[Graphical view]
PIRSFiPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMiSSF52954. SSF52954. 1 hit.
TIGRFAMsiTIGR00442. hisS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O51160-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIKTLKGFK DYLPKDSLIR IHIVRQIFSV LNSYNFDLID TPVLEYSDLL
60 70 80 90 100
LKKSGDETEK QIYRFKDNGG RDVSMRFDLT VPFARFVATN ISALKLPFRR
110 120 130 140 150
SQFGKVFRGE NSQKGRYREF MQFDFDIVGE DTFRGDAEIL SVVYYGLEEI
160 170 180 190 200
FLNFIEGINK KFIIHYSHIG ILNSFFEKLG LKEKSIFILR NIDKIDKIGI
210 220 230 240 250
DKVKEALLLE IEKEAVDSIL SLVSLQGTFK DKIQALKSIL GDNESIKRVE
260 270 280 290 300
DVFQHLSLLK IQDSFNLNLK ISRGLDYYTG IVFESEVFGS NMGSVCSGGR
310 320 330 340 350
YDNLVSSFSN SIQKISGVGG SFGVDRIKDI IDLEKFSYIK IFVTKARSKV
360 370 380 390 400
LIVNLDSALQ NYYYELATRF RNHDYSKVKN ISCEVYFKNK NGKNIKEQIE
410 420 430 440 450
YALSKEIRFL VFVGQEEYKE NKMKVRDLTK KEELLLSFEE SINLIKCNEK

LLCTPF
Length:456
Mass (Da):52,718
Last modified:April 18, 2012 - v2
Checksum:i16FF8083798BF319
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000783 Genomic DNA. Translation: AAC66531.2.
PIRiG70116.
RefSeqiNP_212269.2. NC_001318.1.
WP_002656264.1. NC_001318.1.

Genome annotation databases

EnsemblBacteriaiAAC66531; AAC66531; BB_0135.
GeneIDi1194970.
KEGGibbu:BB_0135.
PATRICi20556876. VBIBorBur75917_0533.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000783 Genomic DNA. Translation: AAC66531.2.
PIRiG70116.
RefSeqiNP_212269.2. NC_001318.1.
WP_002656264.1. NC_001318.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224326.BB_0135.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC66531; AAC66531; BB_0135.
GeneIDi1194970.
KEGGibbu:BB_0135.
PATRICi20556876. VBIBorBur75917_0533.

Phylogenomic databases

eggNOGiCOG0124.
KOiK01892.
OMAiFMATNKS.

Enzyme and pathway databases

BioCyciBBUR224326:G9SO-134-MONOMER.

Family and domain databases

Gene3Di3.40.50.800. 1 hit.
HAMAPiMF_00127. His_tRNA_synth.
InterProiIPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
[Graphical view]
PANTHERiPTHR11476. PTHR11476. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
[Graphical view]
PIRSFiPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMiSSF52954. SSF52954. 1 hit.
TIGRFAMsiTIGR00442. hisS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.

Entry informationi

Entry nameiSYH_BORBU
AccessioniPrimary (citable) accession number: O51160
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: April 18, 2012
Last modified: July 22, 2015
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.