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O51160 (SYH_BORBU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histidine--tRNA ligase

EC=6.1.1.21
Alternative name(s):
Histidyl-tRNA synthetase
Short name=HisRS
Gene names
Name:hisS
Ordered Locus Names:BB_0135
OrganismBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680) [Reference proteome] [HAMAP]
Taxonomic identifier224326 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group

Protein attributes

Sequence length456 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His). HAMAP-Rule MF_00127

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00127

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00127.

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processhistidyl-tRNA aminoacylation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

histidine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 456456Histidine--tRNA ligase HAMAP-Rule MF_00127
PRO_0000136120

Sequences

Sequence LengthMass (Da)Tools
O51160 [UniParc].

Last modified April 18, 2012. Version 2.
Checksum: 16FF8083798BF319

FASTA45652,718
        10         20         30         40         50         60 
MDIKTLKGFK DYLPKDSLIR IHIVRQIFSV LNSYNFDLID TPVLEYSDLL LKKSGDETEK 

        70         80         90        100        110        120 
QIYRFKDNGG RDVSMRFDLT VPFARFVATN ISALKLPFRR SQFGKVFRGE NSQKGRYREF 

       130        140        150        160        170        180 
MQFDFDIVGE DTFRGDAEIL SVVYYGLEEI FLNFIEGINK KFIIHYSHIG ILNSFFEKLG 

       190        200        210        220        230        240 
LKEKSIFILR NIDKIDKIGI DKVKEALLLE IEKEAVDSIL SLVSLQGTFK DKIQALKSIL 

       250        260        270        280        290        300 
GDNESIKRVE DVFQHLSLLK IQDSFNLNLK ISRGLDYYTG IVFESEVFGS NMGSVCSGGR 

       310        320        330        340        350        360 
YDNLVSSFSN SIQKISGVGG SFGVDRIKDI IDLEKFSYIK IFVTKARSKV LIVNLDSALQ 

       370        380        390        400        410        420 
NYYYELATRF RNHDYSKVKN ISCEVYFKNK NGKNIKEQIE YALSKEIRFL VFVGQEEYKE 

       430        440        450 
NKMKVRDLTK KEELLLSFEE SINLIKCNEK LLCTPF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000783 Genomic DNA. Translation: AAC66531.2.
PIRG70116.
RefSeqNP_212269.2. NC_001318.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224326.BB0135.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC66531; AAC66531; BB_0135.
GeneID1194970.
KEGGbbu:BB_0135.
PATRIC20556876. VBIBorBur75917_0533.

Phylogenomic databases

eggNOGCOG0124.
KOK01892.
OMAGKQIKFA.

Enzyme and pathway databases

BioCycBBUR224326:G9SO-134-MONOMER.

Family and domain databases

Gene3D3.40.50.800. 1 hit.
HAMAPMF_00127. His_tRNA_synth.
InterProIPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
[Graphical view]
PANTHERPTHR11476. PTHR11476. 1 hit.
PfamPF03129. HGTP_anticodon. 1 hit.
[Graphical view]
PIRSFPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMSSF52954. SSF52954. 1 hit.
TIGRFAMsTIGR00442. hisS. 1 hit.
PROSITEPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYH_BORBU
AccessionPrimary (citable) accession number: O51160
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: April 18, 2012
Last modified: May 14, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries