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O51160

- SYH_BORBU

UniProt

O51160 - SYH_BORBU

Protein

Histidine--tRNA ligase

Gene

hisS

Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (18 Apr 2012)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. histidine-tRNA ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. histidyl-tRNA aminoacylation Source: InterPro

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBBUR224326:G9SO-134-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidine--tRNA ligase (EC:6.1.1.21)
    Alternative name(s):
    Histidyl-tRNA synthetase
    Short name:
    HisRS
    Gene namesi
    Name:hisS
    Ordered Locus Names:BB_0135
    OrganismiBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
    Taxonomic identifieri224326 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group
    ProteomesiUP000001807: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 456456Histidine--tRNA ligasePRO_0000136120Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi224326.BB0135.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0124.
    KOiK01892.
    OMAiGKQIKFA.

    Family and domain databases

    Gene3Di3.40.50.800. 1 hit.
    HAMAPiMF_00127. His_tRNA_synth.
    InterProiIPR006195. aa-tRNA-synth_II.
    IPR004154. Anticodon-bd.
    IPR015807. His-tRNA-ligase.
    IPR004516. HisRS/HisZ.
    [Graphical view]
    PANTHERiPTHR11476. PTHR11476. 1 hit.
    PfamiPF03129. HGTP_anticodon. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001549. His-tRNA_synth. 1 hit.
    SUPFAMiSSF52954. SSF52954. 1 hit.
    TIGRFAMsiTIGR00442. hisS. 1 hit.
    PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O51160-1 [UniParc]FASTAAdd to Basket

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    MDIKTLKGFK DYLPKDSLIR IHIVRQIFSV LNSYNFDLID TPVLEYSDLL    50
    LKKSGDETEK QIYRFKDNGG RDVSMRFDLT VPFARFVATN ISALKLPFRR 100
    SQFGKVFRGE NSQKGRYREF MQFDFDIVGE DTFRGDAEIL SVVYYGLEEI 150
    FLNFIEGINK KFIIHYSHIG ILNSFFEKLG LKEKSIFILR NIDKIDKIGI 200
    DKVKEALLLE IEKEAVDSIL SLVSLQGTFK DKIQALKSIL GDNESIKRVE 250
    DVFQHLSLLK IQDSFNLNLK ISRGLDYYTG IVFESEVFGS NMGSVCSGGR 300
    YDNLVSSFSN SIQKISGVGG SFGVDRIKDI IDLEKFSYIK IFVTKARSKV 350
    LIVNLDSALQ NYYYELATRF RNHDYSKVKN ISCEVYFKNK NGKNIKEQIE 400
    YALSKEIRFL VFVGQEEYKE NKMKVRDLTK KEELLLSFEE SINLIKCNEK 450
    LLCTPF 456
    Length:456
    Mass (Da):52,718
    Last modified:April 18, 2012 - v2
    Checksum:i16FF8083798BF319
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000783 Genomic DNA. Translation: AAC66531.2.
    PIRiG70116.
    RefSeqiNP_212269.2. NC_001318.1.

    Genome annotation databases

    EnsemblBacteriaiAAC66531; AAC66531; BB_0135.
    GeneIDi1194970.
    KEGGibbu:BB_0135.
    PATRICi20556876. VBIBorBur75917_0533.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000783 Genomic DNA. Translation: AAC66531.2 .
    PIRi G70116.
    RefSeqi NP_212269.2. NC_001318.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224326.BB0135.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC66531 ; AAC66531 ; BB_0135 .
    GeneIDi 1194970.
    KEGGi bbu:BB_0135.
    PATRICi 20556876. VBIBorBur75917_0533.

    Phylogenomic databases

    eggNOGi COG0124.
    KOi K01892.
    OMAi GKQIKFA.

    Enzyme and pathway databases

    BioCyci BBUR224326:G9SO-134-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.800. 1 hit.
    HAMAPi MF_00127. His_tRNA_synth.
    InterProi IPR006195. aa-tRNA-synth_II.
    IPR004154. Anticodon-bd.
    IPR015807. His-tRNA-ligase.
    IPR004516. HisRS/HisZ.
    [Graphical view ]
    PANTHERi PTHR11476. PTHR11476. 1 hit.
    Pfami PF03129. HGTP_anticodon. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001549. His-tRNA_synth. 1 hit.
    SUPFAMi SSF52954. SSF52954. 1 hit.
    TIGRFAMsi TIGR00442. hisS. 1 hit.
    PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.

    Entry informationi

    Entry nameiSYH_BORBU
    AccessioniPrimary (citable) accession number: O51160
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: April 18, 2012
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3