O51154 (KCY1_BORBU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytidylate kinase 1
Short name=CK 1
EC=2.7.4.25

Alternative name(s):
Cytidine monophosphate kinase 1
Short name=CMP kinase 1

Gene names

Name:	cmk1
Ordered Locus Names:	BB_0128

Organism

Borrelia burgdorferi (Lyme disease spirochete)

Taxonomic identifier

139 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group

Protein attributes

Sequence length	221 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (d)CMP = ADP + (d)CDP. HAMAP MF_00238
Subcellular location	Cytoplasm By similarity HAMAP MF_00238.
Sequence similarities	Belongs to the cytidylate kinase family. Type 1 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cytidylate kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 221	221	Cytidylate kinase 1 HAMAP MF_00238		PRO_0000131886
Regions
	Nucleotide binding	7 – 15	9	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	O51154 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: C82D012F5A942187	FASTA	221	25,602
	10 20 30 40 50 60 MIIAIDGPSA SGKSSIAREL GVRLNYKFIS SGHLYRIITL IAQRSLMNSC DFISEDSLLN 70 80 90 100 110 120 LILENDISFN NFAFLLNGEN VENQILNDKI DFQVSFYSSY VGIRNIVNKK LREVVKFSDD 130 140 150 160 170 180 NYIIEGRDIT TVVFPESEFK IYLDASVKVR ALRRYKQRNG NETLEELERT LKRRDDVDKK 190 200 210 220 KQYGKLKLSK GVFYLDTSYK GLDDVCNIII EKFNLKKVRE R

References

[1]

"Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi." Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A., Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K., Gwinn M.L., Dougherty B.A., Tomb J.-F., Fleischmann R.D., Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J. , Salzberg S.L., Hanson M., van Vugt R., Palmer N., Adams M.D., Gocayne J.D., Weidman J.F., Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C., Garland S.A., Fujii C., Cotton M.D., Horst K., Roberts K.M., Hatch B., Smith H.O., Venter J.C. Nature 390:580-586(1997) [PubMed: 9403685] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000783 Genomic DNA. Translation: AAC66509.1.
PIR	H70115.
RefSeq	NP_212262.1. NC_001318.1.
3D structure databases
ProteinModelPortal	O51154.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBORT00000008839; EBBORP00000008169; EBBORG00000008838.
GeneID	1194963.
GenomeReviews	Gene locus BB_0128 in contig AE000783_GR.
KEGG	bbu:BB0128.
NMPDR	fig|224326.1.peg.512.
PATRIC	20556862. VBIBorBur75917_0526.
TIGR	BB_0128.
Phylogenomic databases
GeneTree	EBGT00050000007027.
HOGENOM	HBG354377.
OMA	GIRNIVN.
PhylomeDB	O51154.
ProtClustDB	CLSK507373.
Enzyme and pathway databases
BioCyc	BBUR224326:BB_0128-MONOMER.
Family and domain databases
HAMAP	MF_00238. Cytidyl_kinase_type1. [Tree]
InterPro	IPR003136. Cytidylate_kin. IPR011994. Cytidylate_kinase_dom. [Graphical view]
KO	K00945.
PANTHER	PTHR21299:SF2. Cytidylate_kin. 1 hit.
Pfam	PF02224. Cytidylate_kin. 1 hit. [Graphical view]
TIGRFAMs	TIGR00017. Cmk. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KCY1_BORBU

Accession

Primary (citable) accession number: O51154

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	June 1, 1998
Last modified:	January 25, 2012
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program