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Reviewed, UniProtKB/Swiss-Prot O51132 (AMPM_BORBU)

Last modified November 3, 2009. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Methionine aminopeptidase
      Short name=MAP
    EC=3.4.11.18
Alternative name(s):
    Peptidase M
Gene names
Name: map
Ordered Locus Names: BB_0105
OrganismBorrelia burgdorferi (Lyme disease spirochete) [Complete proteome] [HAMAP]
Taxonomic identifier139 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group

Protein attributes

Sequence length251 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Removes the amino-terminal methionine from nascent proteins.

Catalytic activity

Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.

Cofactor

Binds 2 cobalt ions per subunit. The true nature of the physiological cofactor is under debate. The enzyme is also active with zinc, manganese or divalent iron ions By similarity.

Sequence similarities

Belongs to the peptidase M24A family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 251251Methionine aminopeptidase
PRO_0000148928

Sites

Metal binding961Cobalt 1 By similarity
Metal binding1071Cobalt 1 By similarity
Metal binding1071Cobalt 2 By similarity
Metal binding1701Cobalt 2 By similarity
Metal binding2041Cobalt 2 By similarity
Metal binding2351Cobalt 1 By similarity
Metal binding2351Cobalt 2 By similarity
Binding site791Substrate By similarity
Binding site1771Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
O51132-1 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 807996A2B082BC1C

FASTA25127,711
        10         20         30         40         50         60 
MTKLRLKSKD EIKKIKASAS LLALTLLEVE RNIVPGISTK ELDLIAYDFI IKNRAKPAFK 

        70         80         90        100        110        120 
GYRGFKGTIC ASVNEEVIHG IPGKRKLADG DIVSIDCGVI LDGFYSDMAK TFKVGNVDSS 

       130        140        150        160        170        180 
IDKLLEVTNA SLYKGIAEMK VGNRILNISK AIEDYIKPFG FGIVREYTGH GVGFELHEEP 

       190        200        210        220        230        240 
SVPNYYAPFF KNIRIQEGMV LAIEPMVNLR GHKVSIKSDG WTVFASDLSY SAHFEHTVAV 

       250 
VDGLPLILSE V 

« Hide

Cross-references

Sequence databases

AE000783 Genomic DNA. Translation: AAC66499.1.
PIRA70113.
RefSeqNP_212239.1.

3D structure databases

HSSPHSSP built from PDB template 1O0X based on UniProtKB Q9X1I7.
ModBaseSearch...

Genome annotation databases

GeneID1194941.
GenomeReviewsGene locus BB_0105 in contig AE000783_GR.
KEGGbbu:BB0105.
NMPDRfig|224326.1.peg.489.
TIGRBB_0105.

Phylogenomic databases

HOGENOMO51132.
OMATATGPRI.

Enzyme and pathway databases

BioCycBBUR224326:BB_0105-MON.
BRENDA3.4.11.18. 142596.

Family and domain databases

InterProIPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002467. Pept_M24A_MAP1.
[Graphical view]
Gene3DG3DSA:3.90.230.10. Peptidase_M24_cat_core. 1 hit.
PANTHERPTHR10804:SF13. Pept_M24A_MAP1. 1 hit.
PTHR10804. Peptidase_M24_cat_core. 1 hit.
PfamPF00557. Peptidase_M24. 1 hit.
[Graphical view]
PRINTSPR00599. MAPEPTIDASE.
TIGRFAMsTIGR00500. met_pdase_I. 1 hit.
PROSITEPS00680. MAP_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAMPM_BORBU
AccessionPrimary (citable) accession number: O51132
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: November 3, 2009
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents