Reviewed, UniProtKB/Swiss-Prot O51127 (MURI_BORBU)

Names and origin

Protein names

Recommended name:
    Glutamate racemase
    EC=5.1.1.3

Gene names

Name:	murI
Ordered Locus Names:	BB_0100

Organism

Borrelia burgdorferi (Lyme disease spirochete) [Complete proteome] [HAMAP]

Taxonomic identifier

139 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group

Protein attributes

Sequence length	261 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Provides the (R)-glutamate required for cell wall biosynthesis By similarity.
Catalytic activity	L-glutamate = D-glutamate. HAMAP MF_00258
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00258
Sequence similarities	Belongs to the aspartate/glutamate racemases family.

Ontologies

Keywords
Biological process	Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glutamate racemase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 261	261	Glutamate racemase HAMAP MF_00258		PRO_0000095456

Sequences

	Sequence		Length	Mass (Da)
	O51127-1 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 2EE4C2AD3CE2A237	FASTA	261	30,330
	10 20 30 40 50 60 MKNFKEVIII FDSGIGGLSY FKYIKSRIGG CQYVYVADNK NFPYGEKSPE YLLEAVLFLI 70 80 90 100 110 120 EKLKKIYNIG ALVLACNTIS VSVYNKLNFV FPVVYTLPDV SSVSDLVLKR VLLIATNTTL 130 140 150 160 170 180 ESKFVKDQVN IHNDLIVKAA GELVNFVEYG ENYKKYALRC LEALKFEVVN TGREIVFLGC 190 200 210 220 230 240 THYLHLKVMI EDFLKIPVYE NRELVVKNLI RSMNFSEHKG NYYKNDFDFV DDEFYLTENK 250 260 NLTFYQNFCK KYNLRFKGMI V

References

[1]

"Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi." Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A., Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K., Gwinn M.L., Dougherty B.A., Tomb J.-F., Fleischmann R.D., Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J. , Salzberg S.L., Hanson M., van Vugt R., Palmer N., Adams M.D., Gocayne J.D., Weidman J.F., Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C., Garland S.A., Fujii C., Cotton M.D., Horst K., Roberts K.M., Hatch B., Smith H.O., Venter J.C. Nature 390:580-586(1997) [PubMed: 9403685] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE000783 Genomic DNA. Translation: AAC66479.1.
PIR	D70112.
RefSeq	NP_212234.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1194936.
GenomeReviews	Gene locus BB_0100 in contig AE000783_GR.
KEGG	bbu:BB0100.
NMPDR	fig|224326.1.peg.484.
TIGR	BB_0100.
Phylogenomic databases
HOGENOM	O51127.
OMA	GCTHYLH.
Enzyme and pathway databases
BioCyc	BBUR224326:BB_0100-MON.
BRENDA	5.1.1.3. 142596.
Family and domain databases
HAMAP	MF_00258. [Tree]
InterPro	IPR015942. Asp/Glu/hydantoin_racemase. IPR001920. Asp/Glu_race. IPR018187. Asp/Glu_racemase_AS. IPR004391. Glu_race. [Graphical view]
Gene3D	G3DSA:3.40.50.1860. Asp/Glu_race. 1 hit.
Pfam	PF01177. Asp_Glu_race. 1 hit. [Graphical view]
TIGRFAMs	TIGR00067. glut_race. 1 hit.
PROSITE	PS00923. ASP_GLU_RACEMASE_1. False negative. PS00924. ASP_GLU_RACEMASE_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MURI_BORBU

Accession

Primary (citable) accession number: O51127

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	June 1, 1998
Last modified:	November 3, 2009
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)