O51118 (VATI_BORBU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
V-type ATP synthase subunit I

Alternative name(s):
V-ATPase subunit I

Gene names

Name:	atpI
Ordered Locus Names:	BB_0091

Organism

Borrelia burgdorferi (Lyme disease spirochete)

Taxonomic identifier

139 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group

Protein attributes

Sequence length	608 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Produces ATP from ADP in the presence of a proton gradient across the membrane.
Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the V-ATPase 116 kDa subunit family.

Ontologies

Keywords
Biological process	Hydrogen ion transport Ion transport Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ATP hydrolysis coupled proton transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell proton-transporting two-sector ATPase complex, proton-transporting domain Inferred from electronic annotation. Source: InterPro
Molecular function	hydrogen ion transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 608	608	V-type ATP synthase subunit I		PRO_0000119237
Regions
	Transmembrane	308 – 325	18	Helical; Potential
	Transmembrane	327 – 346	20	Helical; Potential
	Transmembrane	356 – 376	21	Helical; Potential
	Transmembrane	405 – 425	21	Helical; Potential
	Transmembrane	438 – 458	21	Helical; Potential
	Transmembrane	464 – 484	21	Helical; Potential
	Transmembrane	495 – 515	21	Helical; Potential
	Transmembrane	517 – 537	21	Helical; Potential
	Transmembrane	550 – 570	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	O51118 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 4B430DF23A521A36	FASTA	608	69,123
	10 20 30 40 50 60 MIVKMKKVLL LTLSKYKKES LEILRDFGAV HINSCNKNSD SLKKSIDDRR ILMQAFSLLK 70 80 90 100 110 120 EDGGVKALKS SNGNFLDIAK SIVNLGNEIK EFQDIKRSLL HERNLISVWG NFSLENIDEL 130 140 150 160 170 180 KESNIYIQFF KIQKSEYKNL LRDPNVNVLL IKNVKNTSYF VSVGEFEQKI EIADEFKFNF 190 200 210 220 230 240 DLDYINNKLK VVDEILDQKL TQISLFNKYI DILRDEIKNY DQIVEFEQVL ADMQTDXEDF 250 260 270 280 290 300 SYITGFVPAE SQESLKNAVL KAGFAAQFAD PEENDIIPTY IKRKGIANLA APIFNILETI 310 320 330 340 350 360 PGYKERDISF IFMLFFFVFF GMIIGDAAYG VIFFLIGILL SLSFLLKGKP LTPFHGLIFY 370 380 390 400 410 420 LSVSSILYGA MTGTWFGSPL ILEMFPILNS FKVSYLTEKN SVQNIIFICF SIGVLQISLA 430 440 450 460 470 480 HVWNFFRQVK EKPHIHSIAQ IGWLMCIVGL YYLVLNLILS QSRFPMYNVV YNVIYFGVAL 490 500 510 520 530 540 VFVFGKQDGS NFFKCILKSF GGIIEQFLTT VSGFADIISY IRLFAVGLAG LSISASFNTM 550 560 570 580 590 600 SIPLLKSSNI GLIVAGIIVI LFGHVLNIML SLLSVIVHGV RLNMLEFSNH LGQEWSGCAY RPFKKMKK

References

[1]

"Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi." Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A., Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K., Gwinn M.L., Dougherty B.A., Tomb J.-F., Fleischmann R.D., Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J. , Salzberg S.L., Hanson M., van Vugt R., Palmer N., Adams M.D., Gocayne J.D., Weidman J.F., Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C., Garland S.A., Fujii C., Cotton M.D., Horst K., Roberts K.M., Hatch B., Smith H.O., Venter J.C. Nature 390:580-586(1997) [PubMed: 9403685] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000783 Genomic DNA. Translation: AAC66486.1.
PIR	C70111.
RefSeq	NP_212225.1. NC_001318.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBORT00000008706; EBBORP00000008036; EBBORG00000008705.
GeneID	1194927.
GenomeReviews	Gene locus BB_0091 in contig AE000783_GR.
KEGG	bbu:BB0091.
NMPDR	fig|224326.1.peg.475.
PATRIC	20556788. VBIBorBur75917_0489.
TIGR	BB_0091.
Phylogenomic databases
GeneTree	EBGT00050000007378.
HOGENOM	HBG354204.
OMA	YIRLFAV.
ProtClustDB	PRK05771.
Enzyme and pathway databases
BioCyc	BBUR224326:BB_0091-MONOMER.
Family and domain databases
InterPro	IPR002490. ATPase_V0/A0-cplx_116kDa_su. [Graphical view]
KO	K02123.
Pfam	PF01496. V_ATPase_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VATI_BORBU

Accession

Primary (citable) accession number: O51118

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2001
Last sequence update:	June 1, 1998
Last modified:	January 25, 2012
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program