O51069 (CHER_BORBU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chemotaxis protein methyltransferase
EC=2.1.1.80

Gene names

Name:	cheR
Ordered Locus Names:	BB_0040

Organism

Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680) [Reference proteome] [HAMAP]

Taxonomic identifier

224326 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Spirochaetes › Spirochaetia › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group › Borrelia burgdorferi

Protein attributes

Sequence length	283 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP By similarity.
Catalytic activity	S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate methyl ester.
Sequence similarities	Contains 1 cheR-type methyltransferase domain.

Ontologies

Keywords
Biological process	Chemotaxis
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chemotaxis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	protein-glutamate O-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 283	283	Chemotaxis protein methyltransferase		PRO_0000176031
Regions
	Domain	7 – 283	277	CheR-type methyltransferase
	Region	212 – 213	2	S-adenosyl-L-methionine binding By similarity
	Region	230 – 231	2	S-adenosyl-L-methionine binding By similarity
Sites
	Binding site	84	1	S-adenosyl-L-methionine By similarity
	Binding site	86	1	S-adenosyl-L-methionine By similarity
	Binding site	90	1	S-adenosyl-L-methionine By similarity
	Binding site	130	1	S-adenosyl-L-methionine By similarity
	Binding site	157	1	S-adenosyl-L-methionine By similarity

Sequences

	Sequence		Length	Mass (Da)
	O51069 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 2FF0E4E9C8BC3EEE	FASTA	283	33,560
	10 20 30 40 50 60 MNTNQNKFNL NINITKDELS RLIKIVYNNF GINLSEKKKL LIESRLSSLL KVKGFKNFTE 70 80 90 100 110 120 YINFLEKSTG NIQLIELIDK ISTNHTYFFR ESKHFDFLNN KILPKLTEKI LNSENSEIRI 130 140 150 160 170 180 WSAGCSSGEE PYTIAMMLKE YMEHNRVNFK VKILATDISI SVLNEAREGI YPEDRIINLP 190 200 210 220 230 240 KYLKIKYLNQ LQDDKFQVKE ILKKMVYFKK LNLMDEKFPF SKKFDLIFCR NVMIYFDEKT 250 260 270 280 RNNLANKFNS YLKKDSYLLI GHSETIRGNK NLEYIMPATY KKN

References

[1]

"Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi." Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A., Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K., Gwinn M.L., Dougherty B.A., Tomb J.-F., Fleischmann R.D., Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J. , Salzberg S.L., Hanson M., van Vugt R., Palmer N., Adams M.D., Gocayne J.D., Weidman J.F., Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C., Garland S.A., Fujii C., Cotton M.D., Horst K., Roberts K.M., Hatch B., Smith H.O., Venter J.C. Nature 390:580-586(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000783 Genomic DNA. Translation: AAC66439.1.
PIR	H70104.
RefSeq	NP_212174.1. NC_001318.1.
3D structure databases
ProteinModelPortal	O51069.
ModBase	Search...
Protein-protein interaction databases
STRING	224326.BB0040.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC66439; AAC66439; BB_0040.
GeneID	1194876.
KEGG	bbu:BB_0040.
PATRIC	20556685. VBIBorBur75917_0439.
Phylogenomic databases
eggNOG	COG1352.
KO	K00575.
OMA	NELNLMA.
ProtClustDB	CLSK544891.
Enzyme and pathway databases
BioCyc	BBUR224326:BB_0040-MONOMER.
Family and domain databases
Gene3D	1.10.155.10. 1 hit.
InterPro	IPR026024. Chemotaxis_MeTrfase_CheR. IPR022642. CheR_C. IPR000780. CheR_MeTrfase. IPR022641. CheR_N. [Graphical view]
Pfam	PF01739. CheR. 1 hit. PF03705. CheR_N. 1 hit. [Graphical view]
PIRSF	PIRSF000410. CheR. 1 hit.
PRINTS	PR00996. CHERMTFRASE.
SMART	SM00138. MeTrc. 1 hit. [Graphical view]
SUPFAM	SSF47757. CheR_mtfrase. 1 hit.
PROSITE	PS50123. CHER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CHER_BORBU

Accession

Primary (citable) accession number: O51069

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	June 1, 1998
Last modified:	May 1, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program