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O51038

- SYW_BORBU

UniProt

O51038 - SYW_BORBU

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Protein
Tryptophan--tRNA ligase
Gene
trpS, trsA, BB_0005
Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei201 – 2011ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBBUR224326:G9SO-5-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligase (EC:6.1.1.2)
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name:
TrpRS
Gene namesi
Name:trpS
Synonyms:trsA
Ordered Locus Names:BB_0005
OrganismiBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Taxonomic identifieri224326 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group
ProteomesiUP000001807: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351Tryptophan--tRNA ligaseUniRule annotation
PRO_0000136604Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi224326.BB0005.

Structurei

3D structure databases

ProteinModelPortaliO51038.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi12 – 209"HIGH" regionUniRule annotation
Motifi198 – 2025"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0180.
KOiK01867.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00140_B. Trp_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O51038-1 [UniParc]FASTAAdd to Basket

« Hide

MKRKVMLTGD RPTGALHLGH YVGSVVNRLK FQEEYETYFI IADLHTLTTK    50
PDLKSINTIP SNVREMVLDY LACGINPDKV SIYLQSAIPE LFELHLIFSM 100
IVTVARLQRI PSIKDMSIAA GLKEIPYGLL GYPVLMSADI LMTKANLVPV 150
GRDNESHIEF ARELARRFNH LYKNNFFPIP ESVFTDSRPL VGIYGKNKMS 200
KSLDNAIFLN DDENLLEKKI MSMYTDPNRI RADIPGNVEG NPIFIYHSFF 250
NSNHEEVEDL KSRYKKGKVG DVEVKKKLFL ALNSFLKPIR DKRSFYEAKK 300
KDYIDEIIFD GTSKARFIAN KVVKDVKDLI GLSKTWNGIK YSAEKKLKNE 350
E 351
Length:351
Mass (Da):40,193
Last modified:April 18, 2012 - v2
Checksum:i3BEA82CD39838DC6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000783 Genomic DNA. Translation: AAC66398.2.
PIRiE70100.
RefSeqiNP_212139.2. NC_001318.1.

Genome annotation databases

EnsemblBacteriaiAAC66398; AAC66398; BB_0005.
GeneIDi1194841.
KEGGibbu:BB_0005.
PATRICi20556613. VBIBorBur75917_0403.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000783 Genomic DNA. Translation: AAC66398.2 .
PIRi E70100.
RefSeqi NP_212139.2. NC_001318.1.

3D structure databases

ProteinModelPortali O51038.
ModBasei Search...

Protein-protein interaction databases

STRINGi 224326.BB0005.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC66398 ; AAC66398 ; BB_0005 .
GeneIDi 1194841.
KEGGi bbu:BB_0005.
PATRICi 20556613. VBIBorBur75917_0403.

Phylogenomic databases

eggNOGi COG0180.
KOi K01867.

Enzyme and pathway databases

BioCyci BBUR224326:G9SO-5-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00140_B. Trp_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view ]
PANTHERi PTHR10055. PTHR10055. 1 hit.
Pfami PF00579. tRNA-synt_1b. 1 hit.
[Graphical view ]
PRINTSi PR01039. TRNASYNTHTRP.
TIGRFAMsi TIGR00233. trpS. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.

Entry informationi

Entry nameiSYW_BORBU
AccessioniPrimary (citable) accession number: O51038
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: April 18, 2012
Last modified: May 14, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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