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O51038 (SYW_BORBU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan--tRNA ligase

EC=6.1.1.2
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name=TrpRS
Gene names
Name:trpS
Synonyms:trsA
Ordered Locus Names:BB_0005
OrganismBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680) [Reference proteome] [HAMAP]
Taxonomic identifier224326 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group

Protein attributes

Sequence length351 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp). HAMAP-Rule MF_00140_B

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00140_B

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00140_B.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtryptophanyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tryptophan-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 351351Tryptophan--tRNA ligase HAMAP-Rule MF_00140_B
PRO_0000136604

Regions

Motif12 – 209"HIGH" region HAMAP-Rule MF_00140_B
Motif198 – 2025"KMSKS" region HAMAP-Rule MF_00140_B

Sites

Binding site2011ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
O51038 [UniParc].

Last modified April 18, 2012. Version 2.
Checksum: 3BEA82CD39838DC6

FASTA35140,193
        10         20         30         40         50         60 
MKRKVMLTGD RPTGALHLGH YVGSVVNRLK FQEEYETYFI IADLHTLTTK PDLKSINTIP 

        70         80         90        100        110        120 
SNVREMVLDY LACGINPDKV SIYLQSAIPE LFELHLIFSM IVTVARLQRI PSIKDMSIAA 

       130        140        150        160        170        180 
GLKEIPYGLL GYPVLMSADI LMTKANLVPV GRDNESHIEF ARELARRFNH LYKNNFFPIP 

       190        200        210        220        230        240 
ESVFTDSRPL VGIYGKNKMS KSLDNAIFLN DDENLLEKKI MSMYTDPNRI RADIPGNVEG 

       250        260        270        280        290        300 
NPIFIYHSFF NSNHEEVEDL KSRYKKGKVG DVEVKKKLFL ALNSFLKPIR DKRSFYEAKK 

       310        320        330        340        350 
KDYIDEIIFD GTSKARFIAN KVVKDVKDLI GLSKTWNGIK YSAEKKLKNE E 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000783 Genomic DNA. Translation: AAC66398.2.
PIRE70100.
RefSeqNP_212139.2. NC_001318.1.

3D structure databases

ProteinModelPortalO51038.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224326.BB0005.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC66398; AAC66398; BB_0005.
GeneID1194841.
KEGGbbu:BB_0005.
PATRIC20556613. VBIBorBur75917_0403.

Phylogenomic databases

eggNOGCOG0180.
KOK01867.
ProtClustDBPRK00927.

Enzyme and pathway databases

BioCycBBUR224326:G9SO-5-MONOMER.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00140_B. Trp_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERPTHR10055. PTHR10055. 1 hit.
PfamPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSPR01039. TRNASYNTHTRP.
TIGRFAMsTIGR00233. trpS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYW_BORBU
AccessionPrimary (citable) accession number: O51038
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: April 18, 2012
Last modified: February 19, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries