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O51038

- SYW_BORBU

UniProt

O51038 - SYW_BORBU

Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 2 (18 Apr 2012)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei201 – 2011ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBBUR224326:G9SO-5-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan--tRNA ligase (EC:6.1.1.2)
    Alternative name(s):
    Tryptophanyl-tRNA synthetase
    Short name:
    TrpRS
    Gene namesi
    Name:trpS
    Synonyms:trsA
    Ordered Locus Names:BB_0005
    OrganismiBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
    Taxonomic identifieri224326 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group
    ProteomesiUP000001807: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 351351Tryptophan--tRNA ligasePRO_0000136604Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi224326.BB0005.

    Structurei

    3D structure databases

    ProteinModelPortaliO51038.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi12 – 209"HIGH" region
    Motifi198 – 2025"KMSKS" region

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0180.
    KOiK01867.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00140_B. Trp_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR024109. Trp-tRNA-ligase_bac-type.
    [Graphical view]
    PANTHERiPTHR10055. PTHR10055. 1 hit.
    PfamiPF00579. tRNA-synt_1b. 1 hit.
    [Graphical view]
    PRINTSiPR01039. TRNASYNTHTRP.
    TIGRFAMsiTIGR00233. trpS. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O51038-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKRKVMLTGD RPTGALHLGH YVGSVVNRLK FQEEYETYFI IADLHTLTTK    50
    PDLKSINTIP SNVREMVLDY LACGINPDKV SIYLQSAIPE LFELHLIFSM 100
    IVTVARLQRI PSIKDMSIAA GLKEIPYGLL GYPVLMSADI LMTKANLVPV 150
    GRDNESHIEF ARELARRFNH LYKNNFFPIP ESVFTDSRPL VGIYGKNKMS 200
    KSLDNAIFLN DDENLLEKKI MSMYTDPNRI RADIPGNVEG NPIFIYHSFF 250
    NSNHEEVEDL KSRYKKGKVG DVEVKKKLFL ALNSFLKPIR DKRSFYEAKK 300
    KDYIDEIIFD GTSKARFIAN KVVKDVKDLI GLSKTWNGIK YSAEKKLKNE 350
    E 351
    Length:351
    Mass (Da):40,193
    Last modified:April 18, 2012 - v2
    Checksum:i3BEA82CD39838DC6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000783 Genomic DNA. Translation: AAC66398.2.
    PIRiE70100.
    RefSeqiNP_212139.2. NC_001318.1.

    Genome annotation databases

    EnsemblBacteriaiAAC66398; AAC66398; BB_0005.
    GeneIDi1194841.
    KEGGibbu:BB_0005.
    PATRICi20556613. VBIBorBur75917_0403.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000783 Genomic DNA. Translation: AAC66398.2 .
    PIRi E70100.
    RefSeqi NP_212139.2. NC_001318.1.

    3D structure databases

    ProteinModelPortali O51038.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224326.BB0005.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC66398 ; AAC66398 ; BB_0005 .
    GeneIDi 1194841.
    KEGGi bbu:BB_0005.
    PATRICi 20556613. VBIBorBur75917_0403.

    Phylogenomic databases

    eggNOGi COG0180.
    KOi K01867.

    Enzyme and pathway databases

    BioCyci BBUR224326:G9SO-5-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00140_B. Trp_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR024109. Trp-tRNA-ligase_bac-type.
    [Graphical view ]
    PANTHERi PTHR10055. PTHR10055. 1 hit.
    Pfami PF00579. tRNA-synt_1b. 1 hit.
    [Graphical view ]
    PRINTSi PR01039. TRNASYNTHTRP.
    TIGRFAMsi TIGR00233. trpS. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.

    Entry informationi

    Entry nameiSYW_BORBU
    AccessioniPrimary (citable) accession number: O51038
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: April 18, 2012
    Last modified: October 1, 2014
    This is version 90 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3