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O50917

- DBPA_BORBU

UniProt

O50917 - DBPA_BORBU

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Protein

Decorin-binding protein A

Gene

dbpA

Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Binds to decorin which may mediate the adherence of B.burgdorferi to collagen fibers in skin and other tissues.

Enzyme and pathway databases

BioCyciBBUR224326:G9SO-884-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Decorin-binding protein A
Gene namesi
Name:dbpA
Ordered Locus Names:BB_A24
Encoded oniPlasmid lp540 Publication
OrganismiBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Taxonomic identifieri224326 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group
ProteomesiUP000001807: Plasmid lp54

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Chaini30 – 191162Decorin-binding protein APRO_0000021074Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224326.BBA24.

Structurei

Secondary structure

1
191
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni28 – 303Combined sources
Helixi31 – 5525Combined sources
Beta strandi72 – 743Combined sources
Helixi76 – 10328Combined sources
Turni104 – 1063Combined sources
Helixi108 – 12922Combined sources
Helixi134 – 14411Combined sources
Helixi150 – 17526Combined sources
Helixi177 – 1804Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LQUNMR-A24-191[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the decorin-binding protein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG148274.
OMAiGEFSAMY.
OrthoDBiEOG6Z0QD4.

Family and domain databases

InterProiIPR003332. Decorin-bd.
[Graphical view]
PfamiPF02352. Decorin_bind. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O50917-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIKCNNKTFN NLLKLTILVN LLISCGLTGA TKIRLERSAK DITDEIDAIK
60 70 80 90 100
KDAALKGVNF DAFKDKKTGS GVSENPFILE AKVRATTVAE KFVIAIEEEA
110 120 130 140 150
TKLKETGSSG EFSAMYDLMF EVSKPLQKLG IQEMTKTVSD AAEENPPTTA
160 170 180 190
QGVLEIAKKM REKLQRVHTK NYCTLKKKEN STFTDEKCKN N
Length:191
Mass (Da):21,214
Last modified:June 1, 1998 - v1
Checksum:iAD1F191C774AFEA1
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti34 – 341R → K in strain: 297, LP7 and Sh-2-82.
Natural varianti37 – 371R → S in strain: 297, LP7 and Sh-2-82.
Natural varianti41 – 433DIT → AIV in strain: 297, LP7 and Sh-2-82.
Natural varianti52 – 521D → K in strain: 297, LP7 and Sh-2-82.
Natural varianti55 – 562LK → SM in strain: 297, LP7 and Sh-2-82.
Natural varianti128 – 1281K → E in strain: 297, LP7 and Sh-2-82.
Natural varianti140 – 1401D → M in strain: 297, LP7 and Sh-2-82.
Natural varianti169 – 1691T → K in strain: 297, LP7 and Sh-2-82.
Natural varianti172 – 1732YC → QD in strain: 297, LP7 and Sh-2-82.
Natural varianti179 – 19113ENSTF…KCKNN → NTEDSTAKS in strain: 297, LP7 and Sh-2-82.
Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U75866 Genomic DNA. Translation: AAD05353.1.
AF069253 Genomic DNA. Translation: AAC70026.1.
AF069255 Genomic DNA. Translation: AAC70030.1.
AF069257 Genomic DNA. Translation: AAC70034.1.
AF069286 Genomic DNA. Translation: AAC70064.1.
AF069269 Genomic DNA. Translation: AAC70047.1.
AF069275 Genomic DNA. Translation: AAC70053.1.
AE000790 Genomic DNA. Translation: AAC66250.1.
PIRiH70209.
RefSeqiNP_045697.1. NC_001857.2.
WP_010890380.1. NC_001857.2.

Genome annotation databases

EnsemblBacteriaiAAC66250; AAC66250; BB_A24.
GeneIDi1194347.
KEGGibbu:BB_A24.
PATRICi20558972. VBIBorBur75917_1541.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U75866 Genomic DNA. Translation: AAD05353.1 .
AF069253 Genomic DNA. Translation: AAC70026.1 .
AF069255 Genomic DNA. Translation: AAC70030.1 .
AF069257 Genomic DNA. Translation: AAC70034.1 .
AF069286 Genomic DNA. Translation: AAC70064.1 .
AF069269 Genomic DNA. Translation: AAC70047.1 .
AF069275 Genomic DNA. Translation: AAC70053.1 .
AE000790 Genomic DNA. Translation: AAC66250.1 .
PIRi H70209.
RefSeqi NP_045697.1. NC_001857.2.
WP_010890380.1. NC_001857.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2LQU NMR - A 24-191 [» ]
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224326.BBA24.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC66250 ; AAC66250 ; BB_A24 .
GeneIDi 1194347.
KEGGi bbu:BB_A24.
PATRICi 20558972. VBIBorBur75917_1541.

Phylogenomic databases

eggNOGi NOG148274.
OMAi GEFSAMY.
OrthoDBi EOG6Z0QD4.

Enzyme and pathway databases

BioCyci BBUR224326:G9SO-884-MONOMER.

Family and domain databases

InterProi IPR003332. Decorin-bd.
[Graphical view ]
Pfami PF02352. Decorin_bind. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Adherence of Borrelia burgdorferi to the proteoglycan decorin."
    Guo B.P., Norris S.J., Rosenberg L.C., Hook M.
    Infect. Immun. 63:3467-3472(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 53899 / 297.
  2. "Molecular analysis of sequence heterogeneity among genes encoding decorin binding proteins A and B of Borrelia burgdorferi sensu lato."
    Roberts W.C., Mullikin B.A., Lathigra R., Hanson M.S.
    Infect. Immun. 66:5275-5285(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 3028, ATCC 35210 / B31 / CIP 102532 / DSM 4680, HBNC, LP7 and Sh-2-82.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.

Entry informationi

Entry nameiDBPA_BORBU
AccessioniPrimary (citable) accession number: O50917
Secondary accession number(s): O06876, Q9R8Q5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: June 1, 1998
Last modified: November 26, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Plasmid, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3