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O50917

- DBPA_BORBU

UniProt

O50917 - DBPA_BORBU

Protein

Decorin-binding protein A

Gene

dbpA

Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Binds to decorin which may mediate the adherence of B.burgdorferi to collagen fibers in skin and other tissues.

    Enzyme and pathway databases

    BioCyciBBUR224326:G9SO-884-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Decorin-binding protein A
    Gene namesi
    Name:dbpA
    Ordered Locus Names:BB_A24
    Encoded oniPlasmid lp540 Publication
    OrganismiBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
    Taxonomic identifieri224326 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group
    ProteomesiUP000001807: Plasmid lp54

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Chaini30 – 191162Decorin-binding protein APRO_0000021074Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi224326.BBA24.

    Structurei

    Secondary structure

    1
    191
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni28 – 303
    Helixi31 – 5525
    Beta strandi72 – 743
    Helixi76 – 10328
    Turni104 – 1063
    Helixi108 – 12922
    Helixi134 – 14411
    Helixi150 – 17526
    Helixi177 – 1804

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2LQUNMR-A24-191[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the decorin-binding protein family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG148274.
    OMAiGEFSAMY.
    OrthoDBiEOG6Z0QD4.

    Family and domain databases

    InterProiIPR003332. Decorin-bd.
    [Graphical view]
    PfamiPF02352. Decorin_bind. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O50917-1 [UniParc]FASTAAdd to Basket

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    MIKCNNKTFN NLLKLTILVN LLISCGLTGA TKIRLERSAK DITDEIDAIK    50
    KDAALKGVNF DAFKDKKTGS GVSENPFILE AKVRATTVAE KFVIAIEEEA 100
    TKLKETGSSG EFSAMYDLMF EVSKPLQKLG IQEMTKTVSD AAEENPPTTA 150
    QGVLEIAKKM REKLQRVHTK NYCTLKKKEN STFTDEKCKN N 191
    Length:191
    Mass (Da):21,214
    Last modified:June 1, 1998 - v1
    Checksum:iAD1F191C774AFEA1
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti34 – 341R → K in strain: 297, LP7 and Sh-2-82.
    Natural varianti37 – 371R → S in strain: 297, LP7 and Sh-2-82.
    Natural varianti41 – 433DIT → AIV in strain: 297, LP7 and Sh-2-82.
    Natural varianti52 – 521D → K in strain: 297, LP7 and Sh-2-82.
    Natural varianti55 – 562LK → SM in strain: 297, LP7 and Sh-2-82.
    Natural varianti128 – 1281K → E in strain: 297, LP7 and Sh-2-82.
    Natural varianti140 – 1401D → M in strain: 297, LP7 and Sh-2-82.
    Natural varianti169 – 1691T → K in strain: 297, LP7 and Sh-2-82.
    Natural varianti172 – 1732YC → QD in strain: 297, LP7 and Sh-2-82.
    Natural varianti179 – 19113ENSTF…KCKNN → NTEDSTAKS in strain: 297, LP7 and Sh-2-82.
    Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U75866 Genomic DNA. Translation: AAD05353.1.
    AF069253 Genomic DNA. Translation: AAC70026.1.
    AF069255 Genomic DNA. Translation: AAC70030.1.
    AF069257 Genomic DNA. Translation: AAC70034.1.
    AF069286 Genomic DNA. Translation: AAC70064.1.
    AF069269 Genomic DNA. Translation: AAC70047.1.
    AF069275 Genomic DNA. Translation: AAC70053.1.
    AE000790 Genomic DNA. Translation: AAC66250.1.
    PIRiH70209.
    RefSeqiNP_045697.1. NC_001857.2.
    WP_010890380.1. NC_001857.2.

    Genome annotation databases

    EnsemblBacteriaiAAC66250; AAC66250; BB_A24.
    GeneIDi1194347.
    KEGGibbu:BB_A24.
    PATRICi20558972. VBIBorBur75917_1541.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U75866 Genomic DNA. Translation: AAD05353.1 .
    AF069253 Genomic DNA. Translation: AAC70026.1 .
    AF069255 Genomic DNA. Translation: AAC70030.1 .
    AF069257 Genomic DNA. Translation: AAC70034.1 .
    AF069286 Genomic DNA. Translation: AAC70064.1 .
    AF069269 Genomic DNA. Translation: AAC70047.1 .
    AF069275 Genomic DNA. Translation: AAC70053.1 .
    AE000790 Genomic DNA. Translation: AAC66250.1 .
    PIRi H70209.
    RefSeqi NP_045697.1. NC_001857.2.
    WP_010890380.1. NC_001857.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2LQU NMR - A 24-191 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224326.BBA24.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC66250 ; AAC66250 ; BB_A24 .
    GeneIDi 1194347.
    KEGGi bbu:BB_A24.
    PATRICi 20558972. VBIBorBur75917_1541.

    Phylogenomic databases

    eggNOGi NOG148274.
    OMAi GEFSAMY.
    OrthoDBi EOG6Z0QD4.

    Enzyme and pathway databases

    BioCyci BBUR224326:G9SO-884-MONOMER.

    Family and domain databases

    InterProi IPR003332. Decorin-bd.
    [Graphical view ]
    Pfami PF02352. Decorin_bind. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Adherence of Borrelia burgdorferi to the proteoglycan decorin."
      Guo B.P., Norris S.J., Rosenberg L.C., Hook M.
      Infect. Immun. 63:3467-3472(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 53899 / 297.
    2. "Molecular analysis of sequence heterogeneity among genes encoding decorin binding proteins A and B of Borrelia burgdorferi sensu lato."
      Roberts W.C., Mullikin B.A., Lathigra R., Hanson M.S.
      Infect. Immun. 66:5275-5285(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 3028, ATCC 35210 / B31 / CIP 102532 / DSM 4680, HBNC, LP7 and Sh-2-82.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.

    Entry informationi

    Entry nameiDBPA_BORBU
    AccessioniPrimary (citable) accession number: O50917
    Secondary accession number(s): O06876, Q9R8Q5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 18, 2001
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Plasmid, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3