O50917 (DBPA_BORBU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Decorin-binding protein A

Gene names

Name:	dbpA
Ordered Locus Names:	BB_A24

Encoded on

Plasmid lp54

Organism

Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680) [Reference proteome] [HAMAP]

Taxonomic identifier

224326 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Spirochaetes › Spirochaetia › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group › Borrelia burgdorferi

Protein attributes

Sequence length	191 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds to decorin which may mediate the adherence of B.burgdorferi to collagen fibers in skin and other tissues.
Sequence similarities	Belongs to the decorin-binding protein family.

Ontologies

Keywords
Domain	Signal
Technical term	3D-structure Complete proteome Plasmid Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 29

29

Potential

Chain

30 – 191

162

Decorin-binding protein A

PRO_0000021074

Natural variations

Natural variant

34

1

R → K in strain: 297, LP7 and Sh-2-82.

Natural variant

37

1

R → S in strain: 297, LP7 and Sh-2-82.

Natural variant

41 – 43

3

DIT → AIV in strain: 297, LP7 and Sh-2-82.

Natural variant

52

1

D → K in strain: 297, LP7 and Sh-2-82.

Natural variant

55 – 56

2

LK → SM in strain: 297, LP7 and Sh-2-82.

Natural variant

128

1

K → E in strain: 297, LP7 and Sh-2-82.

Natural variant

140

1

D → M in strain: 297, LP7 and Sh-2-82.

Natural variant

169

1

T → K in strain: 297, LP7 and Sh-2-82.

Natural variant

172 – 173

2

YC → QD in strain: 297, LP7 and Sh-2-82.

Natural variant

179 – 191

13

ENSTF…KCKNN → NTEDSTAKS in strain: 297, LP7 and Sh-2-82.

Secondary structure

1

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191

Helix Strand Turn

Details...

Turn

28 – 30

3

Helix

31 – 55

25

Beta strand

72 – 74

3

Helix

76 – 103

28

Turn

104 – 106

3

Helix

108 – 129

22

Helix

134 – 144

11

Helix

150 – 175

26

Helix

177 – 180

4

Sequences

	Sequence		Length	Mass (Da)
	O50917 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: AD1F191C774AFEA1	FASTA	191	21,214
	10 20 30 40 50 60 MIKCNNKTFN NLLKLTILVN LLISCGLTGA TKIRLERSAK DITDEIDAIK KDAALKGVNF 70 80 90 100 110 120 DAFKDKKTGS GVSENPFILE AKVRATTVAE KFVIAIEEEA TKLKETGSSG EFSAMYDLMF 130 140 150 160 170 180 EVSKPLQKLG IQEMTKTVSD AAEENPPTTA QGVLEIAKKM REKLQRVHTK NYCTLKKKEN 190 STFTDEKCKN N

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Adherence of Borrelia burgdorferi to the proteoglycan decorin." Guo B.P., Norris S.J., Rosenberg L.C., Hook M. Infect. Immun. 63:3467-3472(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 53899 / 297.
[2]	"Molecular analysis of sequence heterogeneity among genes encoding decorin binding proteins A and B of Borrelia burgdorferi sensu lato." Roberts W.C., Mullikin B.A., Lathigra R., Hanson M.S. Infect. Immun. 66:5275-5285(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 3028, ATCC 35210 / B31 / CIP 102532 / DSM 4680, HBNC, LP7 and Sh-2-82.
[3]	"Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi." Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A., Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K., Gwinn M.L., Dougherty B.A., Tomb J.-F., Fleischmann R.D., Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J. , Salzberg S.L., Hanson M., van Vugt R., Palmer N., Adams M.D., Gocayne J.D., Weidman J.F., Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C., Garland S.A., Fujii C., Cotton M.D., Horst K., Roberts K.M., Hatch B., Smith H.O., Venter J.C. Nature 390:580-586(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U75866 Genomic DNA. Translation: AAD05353.1.
AF069253 Genomic DNA. Translation: AAC70026.1.
AF069255 Genomic DNA. Translation: AAC70030.1.
AF069257 Genomic DNA. Translation: AAC70034.1.
AF069286 Genomic DNA. Translation: AAC70064.1.
AF069269 Genomic DNA. Translation: AAC70047.1.
AF069275 Genomic DNA. Translation: AAC70053.1.
AE000790 Genomic DNA. Translation: AAC66250.1.

PIR

H70209.

RefSeq

NP_045697.1. NC_001857.2.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2LQU	NMR	-	A	26-191	[»]

ModBase

Search...

Protein-protein interaction databases

STRING

224326.BBA24.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

AAC66250; AAC66250; BB_A24.

GeneID

1194347.

KEGG

bbu:BB_A24.

PATRIC

20558972. VBIBorBur75917_1541.

Phylogenomic databases

eggNOG

NOG148274.

OMA

GEFSAMY.

ProtClustDB

CLSK541193.

Enzyme and pathway databases

BioCyc

BBUR224326:BB_A24-MONOMER.

Family and domain databases

InterPro

IPR003332. Decorin-bd.
[Graphical view]

Pfam

PF02352. Decorin_bind. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

DBPA_BORBU

Accession

Primary (citable) accession number: O50917
Secondary accession number(s): O06876, Q9R8Q5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 18, 2001
Last sequence update:	June 1, 1998
Last modified:	May 1, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program