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O50917 (DBPA_BORBU) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Decorin-binding protein A
Gene names
Name:dbpA
Ordered Locus Names:BB_A24
Encoded onPlasmid lp54
OrganismBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680) [Reference proteome] [HAMAP]
Taxonomic identifier224326 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group

Protein attributes

Sequence length191 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds to decorin which may mediate the adherence of B.burgdorferi to collagen fibers in skin and other tissues.

Sequence similarities

Belongs to the decorin-binding protein family.

Ontologies

Keywords
   DomainSignal
   Technical term3D-structure
Complete proteome
Plasmid
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Chain30 – 191162Decorin-binding protein A
PRO_0000021074

Natural variations

Natural variant341R → K in strain: 297, LP7 and Sh-2-82.
Natural variant371R → S in strain: 297, LP7 and Sh-2-82.
Natural variant41 – 433DIT → AIV in strain: 297, LP7 and Sh-2-82.
Natural variant521D → K in strain: 297, LP7 and Sh-2-82.
Natural variant55 – 562LK → SM in strain: 297, LP7 and Sh-2-82.
Natural variant1281K → E in strain: 297, LP7 and Sh-2-82.
Natural variant1401D → M in strain: 297, LP7 and Sh-2-82.
Natural variant1691T → K in strain: 297, LP7 and Sh-2-82.
Natural variant172 – 1732YC → QD in strain: 297, LP7 and Sh-2-82.
Natural variant179 – 19113ENSTF…KCKNN → NTEDSTAKS in strain: 297, LP7 and Sh-2-82.

Secondary structure

................. 191
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O50917 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: AD1F191C774AFEA1

FASTA19121,214
        10         20         30         40         50         60 
MIKCNNKTFN NLLKLTILVN LLISCGLTGA TKIRLERSAK DITDEIDAIK KDAALKGVNF 

        70         80         90        100        110        120 
DAFKDKKTGS GVSENPFILE AKVRATTVAE KFVIAIEEEA TKLKETGSSG EFSAMYDLMF 

       130        140        150        160        170        180 
EVSKPLQKLG IQEMTKTVSD AAEENPPTTA QGVLEIAKKM REKLQRVHTK NYCTLKKKEN 

       190 
STFTDEKCKN N 

« Hide

References

« Hide 'large scale' references
[1]"Adherence of Borrelia burgdorferi to the proteoglycan decorin."
Guo B.P., Norris S.J., Rosenberg L.C., Hook M.
Infect. Immun. 63:3467-3472(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 53899 / 297.
[2]"Molecular analysis of sequence heterogeneity among genes encoding decorin binding proteins A and B of Borrelia burgdorferi sensu lato."
Roberts W.C., Mullikin B.A., Lathigra R., Hanson M.S.
Infect. Immun. 66:5275-5285(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 3028, ATCC 35210 / B31 / CIP 102532 / DSM 4680, HBNC, LP7 and Sh-2-82.
[3]"Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi."
Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A., Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K., Gwinn M.L., Dougherty B.A., Tomb J.-F., Fleischmann R.D., Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J. expand/collapse author list , Salzberg S.L., Hanson M., van Vugt R., Palmer N., Adams M.D., Gocayne J.D., Weidman J.F., Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C., Garland S.A., Fujii C., Cotton M.D., Horst K., Roberts K.M., Hatch B., Smith H.O., Venter J.C.
Nature 390:580-586(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U75866 Genomic DNA. Translation: AAD05353.1.
AF069253 Genomic DNA. Translation: AAC70026.1.
AF069255 Genomic DNA. Translation: AAC70030.1.
AF069257 Genomic DNA. Translation: AAC70034.1.
AF069286 Genomic DNA. Translation: AAC70064.1.
AF069269 Genomic DNA. Translation: AAC70047.1.
AF069275 Genomic DNA. Translation: AAC70053.1.
AE000790 Genomic DNA. Translation: AAC66250.1.
PIRH70209.
RefSeqNP_045697.1. NC_001857.2.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2LQUNMR-A26-191[»]
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224326.BBA24.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC66250; AAC66250; BB_A24.
GeneID1194347.
KEGGbbu:BB_A24.
PATRIC20558972. VBIBorBur75917_1541.

Phylogenomic databases

eggNOGNOG148274.
OMAGEFSAMY.
OrthoDBEOG6Z0QD4.
ProtClustDBCLSK541193.

Enzyme and pathway databases

BioCycBBUR224326:G9SO-884-MONOMER.

Family and domain databases

InterProIPR003332. Decorin-bd.
[Graphical view]
PfamPF02352. Decorin_bind. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDBPA_BORBU
AccessionPrimary (citable) accession number: O50917
Secondary accession number(s): O06876, Q9R8Q5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: June 1, 1998
Last modified: November 13, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references