ID   ADEC_BORBU              Reviewed;         548 AA.
AC   O50821;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   05-MAY-2009, entry version 56.
DE   RecName: Full=Adenine deaminase;
DE            Short=Adenase;
DE            Short=Adenine aminase;
DE            EC=3.5.4.2;
GN   Name=ade; OrderedLocusNames=BB_K17;
OS   Borrelia burgdorferi (Lyme disease spirochete).
OG   Plasmid lp36.
OC   Bacteria; Spirochaetes; Spirochaetales; Spirochaetaceae; Borrelia;
OC   Borrelia burgdorferi group.
OX   NCBI_TaxID=139;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35210 / B31 / CIP 102532 / DSM 4680;
RX   MEDLINE=98065943; PubMed=9403685; DOI=10.1038/37551;
RA   Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A.,
RA   Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K.,
RA   Gwinn M.L., Dougherty B.A., Tomb J.-F., Fleischmann R.D.,
RA   Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J.,
RA   Salzberg S.L., Hanson M., van Vugt R., Palmer N., Adams M.D.,
RA   Gocayne J.D., Weidman J.F., Utterback T.R., Watthey L., McDonald L.A.,
RA   Artiach P., Bowman C., Garland S.A., Fujii C., Cotton M.D., Horst K.,
RA   Roberts K.M., Hatch B., Smith H.O., Venter J.C.;
RT   "Genomic sequence of a Lyme disease spirochaete, Borrelia
RT   burgdorferi.";
RL   Nature 390:580-586(1997).
CC   -!- CATALYTIC ACTIVITY: Adenine + H(2)O = hypoxanthine + NH(3).
CC   -!- COFACTOR: Manganese (By similarity).
CC   -!- SIMILARITY: Belongs to the adenine deaminase family.
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DR   EMBL; AE000788; AAC66139.1; -; Genomic_DNA.
DR   PIR; C70253; C70253.
DR   RefSeq; NP_045591.1; -.
DR   GeneID; 1194225; -.
DR   GenomeReviews; AE000788_GR; BB_K17.
DR   KEGG; bbu:BBK17; -.
DR   NMPDR; fig|224326.1.peg.1442; -.
DR   TIGR; BB_K17; -.
DR   HOGENOM; O50821; -.
DR   OMA; O50821; IMIREGS.
DR   BioCyc; BBUR224326:BB_K17-MON; -.
DR   BRENDA; 3.5.4.2; 142596.
DR   GO; GO:0000034; F:adenine deaminase activity; IEA:HAMAP.
DR   GO; GO:0030145; F:manganese ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006146; P:adenine catabolic process; IEA:InterPro.
DR   HAMAP; MF_01518; -; 1.
DR   InterPro; IPR006679; Adenine_deam.
DR   InterPro; IPR006680; Amidohydro_1.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   TIGRFAMs; TIGR01178; ade; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Hydrolase; Manganese; Plasmid.
FT   CHAIN         1    548       Adenine deaminase.
FT                                /FTId=PRO_0000142406.
SQ   SEQUENCE   548 AA;  60864 MW;  012AE5222AD8301E CRC64;
     MDLFKIEANY IDIFNKEIYP ASIAIANGHI ASIEKINATL DEYVLPGFID AHIHIESSFL
     VPSNFAHLVV AHGTVATISD PHEIANVNGI DGINFMINNS KKTEFKFFFG APSCVPALSQ
     EFETSGYVLN DKDIDELMKL DDIYYLAEVM DFKGVINKDI EIINKINSAL KRNKVVDGHA
     PGLSPNLTLK YASSGISTDH ECLTIEDARY KLSLGMKILI REGSAAKNFE SLHPLISECS
     KKYCDSLMFC FDDAHPNDIL NGHINLIVAR AIKHGHDFFD VLKIACINPV LHYKIPVGLL
     RIGDPADFII TKDIKTFKIN KTYINGKLVF NDGISLIPLI NEIPINNFNC SKKSISDFKF
     STKNKMIPVI KCISNQIITH KTMIDSNLLA PDFQSNIAED ILKIAIINRY KDNSKISIGF
     IKNFGIRNGA IGSTVAHDSH NIILVGSNDE YLCKAANTII QNKGGLCALN NEKTIIMELP
     ISGLMSTLSA ERVASQYIKL NDFCKNVLGS RLDDPLMTLS FMSLTVVPHL KINDKGLFDV
     DSFCFVDY
//