Reviewed, UniProtKB/Swiss-Prot O50821 (ADEC_BORBU)

Names and origin

Protein names

Recommended name:
    Adenine deaminase
      Short name=Adenase
      Short name=Adenine aminase
    EC=3.5.4.2

Gene names

Name:	ade
Ordered Locus Names:	BB_K17

Encoded on

Plasmid lp36

Organism

Borrelia burgdorferi (Lyme disease spirochete) [Complete proteome] [HAMAP]

Taxonomic identifier

139 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group

Protein attributes

Sequence length	548 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Adenine + H2O = hypoxanthine + NH3. HAMAP MF_01518
Cofactor	Manganese By similarity.
Sequence similarities	Belongs to the adenine deaminase family.

Ontologies

Keywords
Ligand	Manganese
Molecular function	Hydrolase
Technical term	Complete proteome Plasmid
Gene Ontology (GO)
Biological process	adenine catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	adenine deaminase activity Inferred from electronic annotation. Source: HAMAP manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 548	548	Adenine deaminase HAMAP MF_01518		PRO_0000142406

Sequences

	Sequence		Length	Mass (Da)
	O50821-1 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 012AE5222AD8301E	FASTA	548	60,864
	10 20 30 40 50 60 MDLFKIEANY IDIFNKEIYP ASIAIANGHI ASIEKINATL DEYVLPGFID AHIHIESSFL 70 80 90 100 110 120 VPSNFAHLVV AHGTVATISD PHEIANVNGI DGINFMINNS KKTEFKFFFG APSCVPALSQ 130 140 150 160 170 180 EFETSGYVLN DKDIDELMKL DDIYYLAEVM DFKGVINKDI EIINKINSAL KRNKVVDGHA 190 200 210 220 230 240 PGLSPNLTLK YASSGISTDH ECLTIEDARY KLSLGMKILI REGSAAKNFE SLHPLISECS 250 260 270 280 290 300 KKYCDSLMFC FDDAHPNDIL NGHINLIVAR AIKHGHDFFD VLKIACINPV LHYKIPVGLL 310 320 330 340 350 360 RIGDPADFII TKDIKTFKIN KTYINGKLVF NDGISLIPLI NEIPINNFNC SKKSISDFKF 370 380 390 400 410 420 STKNKMIPVI KCISNQIITH KTMIDSNLLA PDFQSNIAED ILKIAIINRY KDNSKISIGF 430 440 450 460 470 480 IKNFGIRNGA IGSTVAHDSH NIILVGSNDE YLCKAANTII QNKGGLCALN NEKTIIMELP 490 500 510 520 530 540 ISGLMSTLSA ERVASQYIKL NDFCKNVLGS RLDDPLMTLS FMSLTVVPHL KINDKGLFDV DSFCFVDY

References

[1]

"Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi." Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A., Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K., Gwinn M.L., Dougherty B.A., Tomb J.-F., Fleischmann R.D., Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J. , Salzberg S.L., Hanson M., van Vugt R., Palmer N., Adams M.D., Gocayne J.D., Weidman J.F., Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C., Garland S.A., Fujii C., Cotton M.D., Horst K., Roberts K.M., Hatch B., Smith H.O., Venter J.C. Nature 390:580-586(1997) [PubMed: 9403685] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE000788 Genomic DNA. Translation: AAC66139.1.
PIR	C70253.
RefSeq	NP_045591.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1194225.
GenomeReviews	Gene locus BB_K17 in contig AE000788_GR.
KEGG	bbu:BBK17.
NMPDR	fig|224326.1.peg.1442.
TIGR	BB_K17.
Phylogenomic databases
HOGENOM	O50821.
OMA	O50821. IMIREGS.
Enzyme and pathway databases
BioCyc	BBUR224326:BB_K17-MON.
BRENDA	3.5.4.2. 142596.
Family and domain databases
HAMAP	MF_01518. [Tree]
InterPro	IPR006679. Adenine_deam. IPR006680. Amidohydro_1. [Graphical view]
Pfam	PF01979. Amidohydro_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR01178. ade. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ADEC_BORBU

Accession

Primary (citable) accession number: O50821

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	June 1, 1998
Last modified:	May 5, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)