ID   O50665_BORBU            Unreviewed;       236 AA.
AC   O50665;
DT   01-JUN-1998, integrated into UniProtKB/TrEMBL.
DT   01-JUN-1998, sequence version 1.
DT   27-MAR-2024, entry version 106.
DE   SubName: Full=Complement regulator-acquiring surface protein 2 (CRASP-2) {ECO:0000313|EMBL:AAC65998.1};
GN   Name=cspZ {ECO:0000313|EMBL:AAC65998.1};
GN   OrderedLocusNames=BB_H06 {ECO:0000313|EMBL:AAC65998.1};
OS   Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31)
OS   (Borrelia burgdorferi).
OG   Plasmid lp28-3 {ECO:0000313|EMBL:AAC65998.1,
OG   ECO:0000313|Proteomes:UP000001807}.
OC   Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Borreliaceae;
OC   Borreliella.
OX   NCBI_TaxID=224326 {ECO:0000313|EMBL:AAC65998.1, ECO:0000313|Proteomes:UP000001807};
RN   [1] {ECO:0000313|EMBL:AAC65998.1, ECO:0000313|Proteomes:UP000001807}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35210 / B31 / CIP 102532 / DSM 4680
RC   {ECO:0000313|Proteomes:UP000001807};
RC   PLASMID=Plasmid lp28-3 {ECO:0000313|Proteomes:UP000001807};
RX   PubMed=9403685; DOI=10.1038/37551;
RA   Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R., Lathigra R.,
RA   White O., Ketchum K.A., Dodson R., Hickey E.K., Gwinn M., Dougherty B.,
RA   Tomb J.F., Fleischmann R.D., Richardson D., Peterson J., Kerlavage A.R.,
RA   Quackenbush J., Salzberg S., Hanson M., van Vugt R., Palmer N., Adams M.D.,
RA   Gocayne J., Weidman J., Utterback T., Watthey L., McDonald L., Artiach P.,
RA   Bowman C., Garland S., Fuji C., Cotton M.D., Horst K., Roberts K.,
RA   Hatch B., Smith H.O., Venter J.C.;
RT   "Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi.";
RL   Nature 390:580-586(1997).
RN   [2] {ECO:0007829|PDB:4BG0, ECO:0007829|PDB:4CBE}
RP   X-RAY CRYSTALLOGRAPHY (1.83 ANGSTROMS) OF 23-236.
RX   PubMed=24702793; DOI=10.1111/FEBS.12808;
RA   Brangulis K., Petrovskis I., Kazaks A., Bogans J., Otikovs M., Jaudzems K.,
RA   Ranka R., Tars K.;
RT   "Structural characterization of CspZ, a complement regulator factor H and
RT   FHL-1 binding protein from Borrelia burgdorferi.";
RL   FEBS J. 281:2613-2622(2014).
RN   [3] {ECO:0007829|PDB:6ATG}
RP   X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 25-235 IN COMPLEX WITH MG(2+).
RA   Liu A., Yan H., Wu Y., Li Y., Liu J.;
RT   "Insights to complement factor H recruitment by the borrelial CspZ protein
RT   as revealed by structural analysis.";
RL   Submitted (AUG-2017) to the PDB data bank.
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DR   EMBL; AE000784; AAC65998.1; -; Genomic_DNA.
DR   PIR; H70235; H70235.
DR   RefSeq; NP_045500.1; NC_001853.1.
DR   RefSeq; WP_010890313.1; NC_001853.1.
DR   PDB; 4BG0; X-ray; 2.10 A; A=23-236.
DR   PDB; 4CBE; X-ray; 1.83 A; A=23-236.
DR   PDB; 6ATG; X-ray; 1.80 A; B/C=25-235.
DR   PDBsum; 4BG0; -.
DR   PDBsum; 4CBE; -.
DR   PDBsum; 6ATG; -.
DR   AlphaFoldDB; O50665; -.
DR   SMR; O50665; -.
DR   EnsemblBacteria; AAC65998; AAC65998; BB_H06.
DR   KEGG; bbu:BB_H06; -.
DR   PATRIC; fig|224326.49.peg.1367; -.
DR   HOGENOM; CLU_086583_0_0_12; -.
DR   OrthoDB; 352732at2; -.
DR   PHI-base; PHI:9810; -.
DR   Proteomes; UP000001807; Plasmid lp28-3.
DR   Gene3D; 1.20.120.1640; -; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:4BG0, ECO:0007829|PDB:4CBE};
KW   Metal-binding {ECO:0007829|PDB:6ATG};
KW   Plasmid {ECO:0000313|EMBL:AAC65998.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001807};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..236
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004159056"
FT   BINDING         116
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0007829|PDB:6ATG"
FT   BINDING         119
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0007829|PDB:6ATG"
FT   BINDING         127
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0007829|PDB:6ATG"
FT   BINDING         130
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0007829|PDB:6ATG"
SQ   SEQUENCE   236 AA;  27162 MW;  E495AD484F378CDD CRC64;
     MKKSFLSIYM LISISLLSCD VSRLNQRNIN ELKIFVEKAK YYSIKLDAIY NECTGAYNDI
     MTYSEGTFSD QSKVNQAISI FKKDNKIVNK FKELEKIIEE YKPMFLSKLI DDFAIELDQA
     VDNDVSNARH VADSYKKLRK SVVLAYIESF DVISSKFVDS KFVEASKKFV NKAKEFVEEN
     DLIALECIVK TIGDMVNDRE INSRSRYNNF YKKEADFLGA AVELEGAYKA IKQTLL
//