Reviewed, UniProtKB/Swiss-Prot O50595 (ARSC_ACIMU)

Names and origin

Protein names

Recommended name:
    Arsenate reductase
    EC=1.20.4.1
Alternative name(s):
    Arsenical pump modifier

Gene names

Name:

arsC

Encoded on

Plasmid pKW301

Organism

Acidiphilium multivorum

Taxonomic identifier

62140 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Acetobacteraceae › Acidiphilium

Protein attributes

Sequence length	141 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Reduction of arsenate [As(V)] to arsenite [As(III)]. This protein expands the substrate specificity of arsAB pump which can extrude arsenite and antimonite to allow for arsenate pumping and resistance By similarity.
Catalytic activity	Arsenate + glutaredoxin = arsenite + glutaredoxin disulfide + H2O.
Sequence similarities	Belongs to the arsC family.

Ontologies

Keywords
Biological process	Arsenical resistance
Molecular function	Oxidoreductase
Technical term	Plasmid
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW response to arsenic Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	arsenate reductase (glutaredoxin) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 141	141	Arsenate reductase		PRO_0000162535

Sequences

	Sequence		Length	Mass (Da)
	O50595-1 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 1A731B415DAAEE66	FASTA	141	15,851
	10 20 30 40 50 60 MSNITIYHNP ACGTSRNTLE MIRNSGNEPT VIHYLENPPS RDELVKLIAD MGISVRALLR 70 80 90 100 110 120 KNVEPYEELG LEEDKFTDDQ LIDFMLQHPI LINRPIVVTP LGTRLCRPSE VVLDILPDAQ 130 140 KGAFAKEDGE KVVDEAGKRL K

References

[1]

"Expression and regulation of the arsenic resistance operon of Acidiphilium multivorum AIU 301 plasmid pKW301 in Escherichia coli." Suzuki K., Wakao N., Kimura T., Sakka K., Ohmiya K. Appl. Environ. Microbiol. 64:411-418(1998) [PubMed: 9464374] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: AIU 301.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB004659 Genomic DNA. Translation: BAA24824.1.
3D structure databases
HSSP	HSSP built from PDB template 1I9D based on UniProtKB P08692.
SMR	O50595. Positions 3-140.
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.20.4.1. 295593.
Family and domain databases
InterPro	IPR006659. Arsenate_reductase. IPR006660. Arsenate_reductase-like. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF03960. ArsC. 1 hit. [Graphical view]
TIGRFAMs	TIGR00014. arsC. 1 hit.
PROSITE	PS51353. ARSC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARSC_ACIMU

Accession

Primary (citable) accession number: O50595

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	June 1, 1998
Last modified:	June 16, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)