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Protein

Probable ferrochelatase

Gene

hemH

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the ferrous insertion into protoporphyrin IX.By similarity

Catalytic activityi

Protoheme + 2 H+ = protoporphyrin + Fe2+.

Pathwayi: protoheme biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes protoheme from protoporphyrin-IX.
Proteins known to be involved in this subpathway in this organism are:
  1. Probable ferrochelatase (hemH)
This subpathway is part of the pathway protoheme biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes protoheme from protoporphyrin-IX, the pathway protoheme biosynthesis and in Porphyrin-containing compound metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi191IronBy similarity1
Metal bindingi286IronBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Heme biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00252; UER00325.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ferrochelatase (EC:4.99.1.1)
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene namesi
Name:hemH
Ordered Locus Names:SCO5859
ORF Names:SC9B10.26
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001752101 – 375Probable ferrochelataseAdd BLAST375

Proteomic databases

PRIDEiO50533.

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO5859.

Structurei

3D structure databases

ProteinModelPortaliO50533.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ferrochelatase family.Curated

Phylogenomic databases

eggNOGiENOG4107QME. Bacteria.
COG0276. LUCA.
HOGENOMiHOG000060728.
InParanoidiO50533.
KOiK01772.
OMAiMHKDGIT.
OrthoDBiPOG091H041Q.
PhylomeDBiO50533.

Family and domain databases

CDDicd00419. Ferrochelatase_C. 1 hit.
cd03411. Ferrochelatase_N. 1 hit.
HAMAPiMF_00323. Ferrochelatase. 1 hit.
InterProiIPR001015. Ferrochelatase.
IPR033644. Ferrochelatase_C.
IPR033659. Ferrochelatase_N.
[Graphical view]
PANTHERiPTHR11108. PTHR11108. 1 hit.
PfamiPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00109. hemH. 1 hit.

Sequencei

Sequence statusi: Complete.

O50533-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDVLDASPY DALLLLSFGG PEGPDDVVPF LENVTRGRGI PKERLKEVGQ
60 70 80 90 100
HYFLFGGVSP INDQNRALLD ALRKDFAEHG LDLPVYWGNR NWAPYLTDTL
110 120 130 140 150
REMVGDGRRR ILVLATSAYA SYSGCRQYRE NLADALAALE SEGLELPKID
160 170 180 190 200
KLRHYFNHPG FVEPMVDGVV RSLAELPAEV RDGAHIAFCT HSIPTSAADG
210 220 230 240 250
SGPVEEHGDG GAYVRQHLDV ARLIADAVRE RTGVDHPWQL VYQSRSGAPH
260 270 280 290 300
IPWLEPDICD HLEERQAAGV PAVVMAPIGF VSDHMEVLYD LDTEATAKAE
310 320 330 340 350
ELGLPVRRSA TVGADPRFAA AVRDLVLERA GDERGQEVTP CALGTLGASH
360 370
NLCPVGCCPA RAPRPAAAGA DSPYA
Length:375
Mass (Da):40,622
Last modified:June 1, 1998 - v1
Checksum:i650547197DF326FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939125 Genomic DNA. Translation: CAA15816.1.
PIRiT35895.
RefSeqiNP_629982.1. NC_003888.3.
WP_003973161.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAA15816; CAA15816; CAA15816.
GeneIDi1101301.
KEGGisco:SCO5859.
PATRICi23741622. VBIStrCoe124346_5958.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939125 Genomic DNA. Translation: CAA15816.1.
PIRiT35895.
RefSeqiNP_629982.1. NC_003888.3.
WP_003973161.1. NC_003888.3.

3D structure databases

ProteinModelPortaliO50533.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi100226.SCO5859.

Proteomic databases

PRIDEiO50533.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAA15816; CAA15816; CAA15816.
GeneIDi1101301.
KEGGisco:SCO5859.
PATRICi23741622. VBIStrCoe124346_5958.

Phylogenomic databases

eggNOGiENOG4107QME. Bacteria.
COG0276. LUCA.
HOGENOMiHOG000060728.
InParanoidiO50533.
KOiK01772.
OMAiMHKDGIT.
OrthoDBiPOG091H041Q.
PhylomeDBiO50533.

Enzyme and pathway databases

UniPathwayiUPA00252; UER00325.

Family and domain databases

CDDicd00419. Ferrochelatase_C. 1 hit.
cd03411. Ferrochelatase_N. 1 hit.
HAMAPiMF_00323. Ferrochelatase. 1 hit.
InterProiIPR001015. Ferrochelatase.
IPR033644. Ferrochelatase_C.
IPR033659. Ferrochelatase_N.
[Graphical view]
PANTHERiPTHR11108. PTHR11108. 1 hit.
PfamiPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00109. hemH. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHEMH_STRCO
AccessioniPrimary (citable) accession number: O50533
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: October 5, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.