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O50519 (KITH_STRCO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine kinase

EC=2.7.1.21
Gene names
Name:tdk
Ordered Locus Names:SCO5845
ORF Names:SC9B10.12
OrganismStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) [Reference proteome] [HAMAP]
Taxonomic identifier100226 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Protein attributes

Sequence length216 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate. HAMAP-Rule MF_00124

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00124

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00124.

Sequence similarities

Belongs to the thymidine kinase family.

Ontologies

Keywords
   Biological processDNA synthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

thymidine kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 216216Thymidine kinase HAMAP-Rule MF_00124
PRO_0000175029

Regions

Nucleotide binding9 – 168ATP By similarity
Nucleotide binding86 – 894ATP By similarity

Sites

Active site871Proton acceptor Potential

Sequences

Sequence LengthMass (Da)Tools
O50519 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: A04BA1CE8C3B4ADA

FASTA21623,368
        10         20         30         40         50         60 
MPELVFFSGT MDCGKSTLAL QIEHNRSARG LAGMIFTRDD RAGEGKLSSR LGLVTDAVEV 

        70         80         90        100        110        120 
GDGQDLYAHV VDHLSQGGRV DYVIADEAQF LAPDQIDQLA RVVDDLDVDV YAFGITTDFR 

       130        140        150        160        170        180 
SKLFPGSQRL VELADRVEVL QVEALCWCGA RATHNARTVG GVMVVEGAQV VVGDVAQSPD 

       190        200        210 
EIGYEVLCRR HHRRRMTSAT ARAAALSPDV LPVTAT 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL939125 Genomic DNA. Translation: CAA15802.1.
PIRT35881.
RefSeqNP_629968.1. NC_003888.3.

3D structure databases

ProteinModelPortalO50519.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING100226.SCO5845.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAA15802; CAA15802; CAA15802.
GeneID1101287.
KEGGsco:SCO5845.
PATRIC23741592. VBIStrCoe124346_5943.

Phylogenomic databases

eggNOGCOG1435.
HOGENOMHOG000076391.
KOK00857.
OMARTICHCG.
OrthoDBEOG69D3J2.
PhylomeDBO50519.
ProtClustDBPRK04296.

Enzyme and pathway databases

BRENDA2.7.1.21. 5998.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
HAMAPMF_00124. Thymidine_kinase.
InterProIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PfamPF00265. TK. 1 hit.
[Graphical view]
PIRSFPIRSF035805. TK_cell. 1 hit.
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKITH_STRCO
AccessionPrimary (citable) accession number: O50519
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: April 16, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families