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Protein

Thymidine kinase

Gene

tdk

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei87Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 16ATPUniRule annotation8
Nucleotide bindingi86 – 89ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processDNA synthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.21. 5998.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:SCO5845
ORF Names:SC9B10.12
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001750291 – 216Thymidine kinaseAdd BLAST216

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi100226.SCO5845.

Structurei

3D structure databases

ProteinModelPortaliO50519.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107W53. Bacteria.
COG1435. LUCA.
HOGENOMiHOG000076391.
InParanoidiO50519.
KOiK00857.
OMAiRATHNAR.
OrthoDBiPOG091H0659.
PhylomeDBiO50519.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase. 1 hit.
InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiView protein in Pfam
PF00265. TK. 1 hit.
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

O50519-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPELVFFSGT MDCGKSTLAL QIEHNRSARG LAGMIFTRDD RAGEGKLSSR
60 70 80 90 100
LGLVTDAVEV GDGQDLYAHV VDHLSQGGRV DYVIADEAQF LAPDQIDQLA
110 120 130 140 150
RVVDDLDVDV YAFGITTDFR SKLFPGSQRL VELADRVEVL QVEALCWCGA
160 170 180 190 200
RATHNARTVG GVMVVEGAQV VVGDVAQSPD EIGYEVLCRR HHRRRMTSAT
210
ARAAALSPDV LPVTAT
Length:216
Mass (Da):23,368
Last modified:June 1, 1998 - v1
Checksum:iA04BA1CE8C3B4ADA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939125 Genomic DNA. Translation: CAA15802.1.
PIRiT35881.
RefSeqiNP_629968.1. NC_003888.3.
WP_003973175.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAA15802; CAA15802; CAA15802.
GeneIDi1101287.
29663855.
KEGGisco:SCO5845.
PATRICi23741592. VBIStrCoe124346_5943.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939125 Genomic DNA. Translation: CAA15802.1.
PIRiT35881.
RefSeqiNP_629968.1. NC_003888.3.
WP_003973175.1. NC_003888.3.

3D structure databases

ProteinModelPortaliO50519.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi100226.SCO5845.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAA15802; CAA15802; CAA15802.
GeneIDi1101287.
29663855.
KEGGisco:SCO5845.
PATRICi23741592. VBIStrCoe124346_5943.

Phylogenomic databases

eggNOGiENOG4107W53. Bacteria.
COG1435. LUCA.
HOGENOMiHOG000076391.
InParanoidiO50519.
KOiK00857.
OMAiRATHNAR.
OrthoDBiPOG091H0659.
PhylomeDBiO50519.

Enzyme and pathway databases

BRENDAi2.7.1.21. 5998.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase. 1 hit.
InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiView protein in Pfam
PF00265. TK. 1 hit.
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKITH_STRCO
AccessioniPrimary (citable) accession number: O50519
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: April 12, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.