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Protein

Phosphocarrier protein HPr

Gene

ptsH

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei15Pros-phosphohistidine intermediate1

GO - Biological processi

  • phosphoenolpyruvate-dependent sugar phosphotransferase system Source: CACAO

Keywordsi

Biological processPhosphotransferase system, Sugar transport, Transport

Protein family/group databases

TCDBi8.A.8.1.7 the phosphotransferase system hpr (hpr) family

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphocarrier protein HPr
Alternative name(s):
Histidine-containing protein
Gene namesi
Name:ptsH
Ordered Locus Names:SCO5841
ORF Names:SC9B10.08c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi15H → A: Loss of phosphorylation. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001078822 – 93Phosphocarrier protein HPrAdd BLAST92

Proteomic databases

PRIDEiO50515

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO5841

Structurei

3D structure databases

ProteinModelPortaliO50515
SMRiO50515
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 89HPrPROSITE-ProRule annotationAdd BLAST88

Sequence similaritiesi

Belongs to the HPr family.Curated

Phylogenomic databases

eggNOGiENOG410849S Bacteria
ENOG41121W9 LUCA
HOGENOMiHOG000278398
InParanoidiO50515
KOiK11189
OMAiRPGNEFV
OrthoDBiPOG091H03ED
PhylomeDBiO50515

Family and domain databases

CDDicd00367 PTS-HPr_like, 1 hit
Gene3Di3.30.1340.10, 1 hit
InterProiView protein in InterPro
IPR000032 HPr-like
IPR035895 HPr-like_sf
IPR001020 PTS_HPr_His_P_site
PfamiView protein in Pfam
PF00381 PTS-HPr, 1 hit
PRINTSiPR00107 PHOSPHOCPHPR
SUPFAMiSSF55594 SSF55594, 1 hit
TIGRFAMsiTIGR01003 PTS_HPr_family, 1 hit
PROSITEiView protein in PROSITE
PS51350 PTS_HPR_DOM, 1 hit
PS00369 PTS_HPR_HIS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O50515-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAERRVNVGW AEGLHARPAS IFVRAATATG VPVTIAKADG SPVNAASMLA
60 70 80 90
VLGLGAQGGE EIVLASDAEG AEAALERLAK LVAEGLEELP ETV
Length:93
Mass (Da):9,391
Last modified:January 23, 2007 - v3
Checksum:i6F72F379FEFFFF19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939125 Genomic DNA Translation: CAA15798.1
PIRiT35877
RefSeqiNP_629964.1, NC_003888.3
WP_003973180.1, NC_003888.3

Genome annotation databases

EnsemblBacteriaiCAA15798; CAA15798; CAA15798
GeneIDi1101283
34286826
KEGGisco:SCO5841
PATRICifig|100226.15.peg.5938

Similar proteinsi

Entry informationi

Entry nameiPTHP_STRCO
AccessioniPrimary (citable) accession number: O50515
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: January 23, 2007
Last modified: December 20, 2017
This is version 115 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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