Skip Header

Contribute Send feedback
Read comments (?) or add your own

O50465 (Y1250_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uncharacterized MFS-type transporter Rv1250/MT1289
Gene names
Ordered Locus Names:Rv1250, MT1289
OrganismMycobacterium tuberculosis [Reference proteome] [HAMAP]
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length579 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Subcellular location

Cell membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the major facilitator superfamily. EmrB family.

Ontologies

Keywords
   Biological processTransport
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtransmembrane transport

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from direct assay PubMed 15525680. Source: MTBBASE

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 579579Uncharacterized MFS-type transporter Rv1250/MT1289
PRO_0000390688

Regions

Transmembrane20 – 4021Helical; Potential
Transmembrane54 – 7421Helical; Potential
Transmembrane86 – 10621Helical; Potential
Transmembrane142 – 16221Helical; Potential
Transmembrane174 – 19421Helical; Potential
Transmembrane204 – 22421Helical; Potential
Transmembrane234 – 25421Helical; Potential
Transmembrane279 – 29921Helical; Potential
Transmembrane310 – 33021Helical; Potential
Transmembrane335 – 35521Helical; Potential
Transmembrane366 – 38621Helical; Potential
Transmembrane467 – 48721Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
O50465 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: A56979E3DE788694

FASTA57960,908
        10         20         30         40         50         60 
MTTAIRRAAG SSYFRNPWPA LWAMMVGFFM IMLDSTVVAI ANPTIMAQLR IGYATVVWVT 

        70         80         90        100        110        120 
SAYLLAYAVP MLVAGRLGDR FGPKNLYLIG LGVFTVASLG CGLSSGAGML IAARVVQGVG 

       130        140        150        160        170        180 
AGLLTPQTLS TITRIFPAHR RGVALGAWGT VASVASLVGP LAGGALVDSM GWEWIFFVNV 

       190        200        210        220        230        240 
PVGVIGLILA AYLIPALPHH PHRFDWFGVG LSGAGMFLIV FGLQQGQSAN WQPWIWAVIV 

       250        260        270        280        290        300 
GGIGFMSLFV YWQARNAREP LIPLEVFNDR NFSLSNLRIA IIAFAGTGMM LPVTFYAQAV 

       310        320        330        340        350        360 
CGLSPTHTAV LFAPTAIVGG VLAPFVGMII DRSHPLCVLG FGFSVLAIAM TWLLCEMAPG 

       370        380        390        400        410        420 
TPIWRLVLPF IALGVAGAFV WSPLTVTATR NLRPHLAGAS SGVFNAVRQL GAVLGSASMA 

       430        440        450        460        470        480 
AFMTSRIAAE MPGGVDALTG PAGQDATVLQ LPEFVREPFA AAMSQSMLLP AFVALFGIVA 

       490        500        510        520        530        540 
ALFLVDFTGA AVAKEPLPES DGDADDDDYV EYILRREPEE DCDTQPLRAS RPAAAAASRS 

       550        560        570 
GAGGPLAVSW STSAQGMPPG PPGRRAWQAD TESTAPSAL

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000516 Genomic DNA. Translation: AAK45547.1.
AL123456 Genomic DNA. Translation: CCP44006.1.
PIRA70954.
RefSeqNP_215766.1. NC_000962.3.
NP_335733.1. NC_002755.2.
YP_006514625.1. NC_018143.1.

3D structure databases

ProteinModelPortalO50465.
ModBaseSearch...

Protein-protein interaction databases

STRING83332.Rv1250.

PTM databases

PhosSiteP12071680.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK45547; AAK45547; MT1289.
GeneID13319829.
887073.
924781.
KEGGmtc:MT1289.
mtu:Rv1250.
PATRIC18124596. VBIMycTub22151_1417.

Organism-specific databases

TubercuListRv1250.

Phylogenomic databases

eggNOGCOG0477.
HOGENOMHOG000239124.
OMAFLVVQEP.
ProtClustDBCLSK791048.

Family and domain databases

InterProIPR004638. Drug-R_transpt_efflux_EmrB.
IPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMSSF103473. MFS_gen_substrate_transporter. 1 hit.
TIGRFAMsTIGR00711. efflux_EmrB. 1 hit.
PROSITEPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameY1250_MYCTU
AccessionPrimary (citable) accession number: O50465
Secondary accession number(s): L0T635, Q7D8I7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: June 1, 1998
Last modified: May 29, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh

Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents