O50463 (KGD_MYCTU) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 77.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: 2-oxoglutarate decarboxylase EC=4.1.1.71 Alternative name(s): 2-oxoglutarate carboxy-lyase Alpha-ketoglutarate decarboxylase | ||||
| Gene names |
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| Organism | Mycobacterium tuberculosis | ||||
| Taxonomic identifier | 1773 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex |
Protein attributes
| Sequence length | 1231 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Catalyzes an oxidative decarboxylation from five-carbon 2-oxoglutarate (alpha-ketoglutarate) to four-carbon succinate semialdehyde. Ref.3 Ref.4 |
| Catalytic activity | 2-oxoglutarate = succinate semialdehyde + CO2. Ref.4 |
| Cofactor | Magnesium. Ref.4 Thiamine pyrophosphate. Ref.4 |
| Sequence similarities | Belongs to the 2-oxoacid dehydrogenase family. Kgd subfamily. |
| Caution | Was originally (Ref.1 and Ref.2) annotated as sucA because of sequence similarity, however, this protein was shown (Ref.3) not to be able to serve as the E1 component of 2-oxoglutarate dehydrogenase (KDH). |
| Biophysicochemical properties | Kinetic parameters: KM=0.48 mM for alpha-ketoglutarate Ref.4 KM=0.196 mM for magnesium ions KM=0.019 mM for thiamine pyrophosphate |
| Sequence caution | The sequence CAA15904.1 differs from that shown. Reason: Erroneous initiation. |
Ontologies
Sequence annotation (Features)
Sequences
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References
Cross-references
Sequence databases | |
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| EMBL GenBank DDBJ | BX842576 Genomic DNA. Translation: CAA15904.1. Different initiation. AE000516 Genomic DNA. Translation: AAK45544.1. |
| PIR | G70953. |
| RefSeq | NP_335730.1. NC_002755.2. |
3D structure databases | |
| ProteinModelPortal | O50463. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBMYCT00000002347; EBMYCP00000002347; EBMYCG00000002345. EBMYCT00000069310; EBMYCP00000067369; EBMYCG00000069305. |
| GeneID | 924785. |
| GenomeReviews | Gene locus MT1286 in contig AE000516_GR. Gene locus Rv1248c in contig AL123456_GR. |
| KEGG | mtc:MT1286. mtu:Rv1248c. |
| PATRIC | 18124592. VBIMycTub22151_1415. |
| TIGR | MT1286. |
Organism-specific databases | |
| TubercuList | Rv1248c. |
Phylogenomic databases | |
| GeneTree | EBGT00050000014858. |
| HOGENOM | HBG289950. |
| OMA | EGDEPAF. |
| PhylomeDB | O50463. |
| ProtClustDB | PRK12270. |
Family and domain databases | |
| InterPro | IPR001078. 2-oxoacid_DH_actylTfrase. IPR011603. 2oxoglutarate_DH_E1. IPR023213. CAT-like_dom. IPR001017. DH_E1. IPR005475. Transketolase-like_Pyr-bd. [Graphical view] |
| Gene3D | G3DSA:3.30.559.10. CAT-like_dom. 1 hit. |
| KO | K01616. |
| PANTHER | PTHR23152. 2oxoglutarate_DH_E1. 1 hit. |
| Pfam | PF00198. 2-oxoacid_dh. 1 hit. PF00676. E1_dh. 1 hit. PF02779. Transket_pyr. 1 hit. [Graphical view] |
| PIRSF | PIRSF000157. Oxoglu_dh_E1. 1 hit. |
| SMART | SM00861. Transket_pyr. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00239. 2oxo_dh_E1. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | KGD_MYCTU | ||||||||
| Accession | Primary (citable) accession number: O50463 Secondary accession number(s): Q7D8I9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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