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Protein
Submitted name:

Acetoin dehydrogenase

Gene

Rv1245c

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Acetoin dehydrogenaseImported
Submitted name:
Probable short-chain type dehydrogenase/reductaseImported
Gene namesi
Ordered Locus Names:Rv1245cImported
ORF Names:LH57_06810Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome
  • UP000031768 Componenti: Chromosome

Organism-specific databases

TubercuListiRv1245c.

Subcellular locationi

GO - Cellular componenti

  • cell wall Source: MTBBASE
  • plasma membrane Source: MTBBASE
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv1245c.

Structurei

3D structure databases

SMRiO50460. Positions 4-265.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the short-chain dehydrogenases/reductases (SDR) family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107GJV. Bacteria.
ENOG410XQUW. LUCA.
OMAiEWIIGIN.
OrthoDBiEOG6N3CR8.
PhylomeDBiO50460.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O50460-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGFAGKVAV VTGAGSGIGQ ALAIELARSG AKVAISDVDT DGLADTEHRL
60 70 80 90 100
KAISTPVKTD RLDVTEREAF LAYADAVNEH FGTVNQIYNN AGIAFTGDIE
110 120 130 140 150
VSQFKDIERV MDVDFWGVVN GTKAFLPHLI ASGDGHVINI SSVFGLFSAP
160 170 180 190 200
GQAAYNSAKF AVRGFTEALR QEMALAGHPV KVTTVHPGGV KTAIARNATA
210 220 230 240 250
AEGLDQAELA ETFDKRVAHL SPQRAAQIIL TGVAKNKARV LVGVDAKVLD
260 270
LVVRLTGSGY QRIFPIITGR LIPRPR
Length:276
Mass (Da):29,215
Last modified:June 1, 1998 - v1
Checksum:i95E2EA43E916E6F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR13990.1.
AL123456 Genomic DNA. Translation: CCP44001.1.
RefSeqiNP_215761.1. NC_000962.3.
WP_003898788.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiAIR13990; AIR13990; LH57_06810.
CCP44001; CCP44001; Rv1245c.
GeneIDi887091.
KEGGimtu:Rv1245c.
mtv:RVBD_1245c.
PATRICi18124586. VBIMycTub22151_1412.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR13990.1.
AL123456 Genomic DNA. Translation: CCP44001.1.
RefSeqiNP_215761.1. NC_000962.3.
WP_003898788.1. NZ_KK339370.1.

3D structure databases

SMRiO50460. Positions 4-265.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv1245c.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAIR13990; AIR13990; LH57_06810.
CCP44001; CCP44001; Rv1245c.
GeneIDi887091.
KEGGimtu:Rv1245c.
mtv:RVBD_1245c.
PATRICi18124586. VBIMycTub22151_1412.

Organism-specific databases

TubercuListiRv1245c.

Phylogenomic databases

eggNOGiENOG4107GJV. Bacteria.
ENOG410XQUW. LUCA.
OMAiEWIIGIN.
OrthoDBiEOG6N3CR8.
PhylomeDBiO50460.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25618 / H37RvImported and H37RvImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. "Phylogenetic analysis of Mycobacterial species using whole genome sequences."
    Hazbon M.H., Riojas M.A., Damon A.M., Alalade R.O., Cantwell B.J., Monaco A., King S., Sohrabi A.
    Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27294 / TMC 102 / H37RvImported and H37RvImported.

Entry informationi

Entry nameiO50460_MYCTU
AccessioniPrimary (citable) accession number: O50460
Secondary accession number(s): F2GFR7, I6XB23, Q7D8J0
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: May 11, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.