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Protein

60 kDa chaperonin

Gene

groL

Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processStress response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBHAL272558:G1G3A-630-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperoninUniRule annotation
Alternative name(s):
GroEL proteinUniRule annotation
Protein Cpn60UniRule annotation
Gene namesi
Name:groLUniRule annotation
Synonyms:groELUniRule annotation, mopA
Ordered Locus Names:BH0562
OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Taxonomic identifieri272558 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000632731 – 54460 kDa chaperoninAdd BLAST544

Proteomic databases

PRIDEiO50305

Expressioni

Inductioni

By heat shock.

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

Protein-protein interaction databases

STRINGi272558.BH0562

Structurei

3D structure databases

ProteinModelPortaliO50305
SMRiO50305
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ9 Bacteria
COG0459 LUCA
KOiK04077
OMAiTDTDKME
OrthoDBiPOG091H00E7

Family and domain databases

CDDicd03344 GroEL, 1 hit
Gene3Di1.10.560.10, 2 hits
3.30.260.10, 2 hits
3.50.7.10, 1 hit
HAMAPiMF_00600 CH60, 1 hit
InterProiView protein in InterPro
IPR018370 Chaperonin_Cpn60_CS
IPR001844 Chaprnin_Cpn60
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00298 CHAPERONIN60
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 1 hit
TIGRFAMsiTIGR02348 GroEL, 1 hit
PROSITEiView protein in PROSITE
PS00296 CHAPERONINS_CPN60, 1 hit

Sequencei

Sequence statusi: Complete.

O50305-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKDIKFSED ARRSMLRGVD KLADAVKVTL GPKGRNVVLE KKFGSPLITN
60 70 80 90 100
DGVTIAKEIE LEDAFENMGA KLVAEVASKT NDIAGDGTTT ATVLAQAMIR
110 120 130 140 150
EGLKNVTSGA NPMVIRKGIE KATQVAVEEL SKISKPIEGK DSIAQVAAIS
160 170 180 190 200
SADDEVGKII AEAMERVGND GVITIEESKG FSTELEVVEG MQFDRGYASP
210 220 230 240 250
YMVTDSDKME AVLDNPYVLI TDKKISNIQE VLPVLEQVVQ QGKPILIIAE
260 270 280 290 300
DVEGEALATL VVNKLRGTFN AVAVKAPGFG DRRKAMLEDI AILTGGEVIT
310 320 330 340 350
EDLGLDLKSA NITQLGRASK VVVTKENTTI VEGAGESDKI AARVNQIKAQ
360 370 380 390 400
IEETTSDFDK EKLQERLAKL AGGVAVLKVG AATETEMKER KLRIEDALNS
410 420 430 440 450
TRAAVEEGIV AGGGTALVNV IKAVSSIGAE GDEATGVNIV LRALEEPVRQ
460 470 480 490 500
IAHNAGLEGS VIVERLKKEE AGFGFNAATG EWVNMVEAGI VDPTKVTRSA
510 520 530 540
LQHAASVSAM FLTTEAVIAD KPEENEGGGG MPDMGGMGGM GGMM
Length:544
Mass (Da):57,404
Last modified:December 1, 2000 - v2
Checksum:iC769ED81C903C971
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti407E → VK in BAA09494 (PubMed:8987660).Curated1
Sequence conflicti421Missing in BAA09494 (PubMed:8987660).Curated1
Sequence conflicti500A → VP in BAA09494 (PubMed:8987660).Curated1
Sequence conflicti512Missing in BAA09494 (PubMed:8987660).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D55630 Genomic DNA Translation: BAA09494.1
BA000004 Genomic DNA Translation: BAB04281.1
PIRiB83720
JC5130
RefSeqiWP_010896739.1, NC_002570.2

Genome annotation databases

EnsemblBacteriaiBAB04281; BAB04281; BAB04281
KEGGibha:BH0562

Entry informationi

Entry nameiCH60_BACHD
AccessioniPrimary (citable) accession number: O50305
Secondary accession number(s): Q9KFC3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: December 1, 2000
Last modified: May 23, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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