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Protein

60 kDa chaperonin

Gene

groL

Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBHAL272558:GJC5-615-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperoninUniRule annotation
Alternative name(s):
GroEL proteinUniRule annotation
Protein Cpn60UniRule annotation
Gene namesi
Name:groLUniRule annotation
Synonyms:groELUniRule annotation, mopA
Ordered Locus Names:BH0562
OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Taxonomic identifieri272558 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001258 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 54454460 kDa chaperoninPRO_0000063273Add
BLAST

Proteomic databases

PRIDEiO50305.

Expressioni

Inductioni

By heat shock.

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

Protein-protein interaction databases

STRINGi272558.BH0562.

Structurei

3D structure databases

ProteinModelPortaliO50305.
SMRiO50305. Positions 2-526.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ9. Bacteria.
COG0459. LUCA.
KOiK04077.
OMAiKKQMDET.
OrthoDBiPOG091H00E7.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiIPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiPS00296. CHAPERONINS_CPN60. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O50305-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKDIKFSED ARRSMLRGVD KLADAVKVTL GPKGRNVVLE KKFGSPLITN
60 70 80 90 100
DGVTIAKEIE LEDAFENMGA KLVAEVASKT NDIAGDGTTT ATVLAQAMIR
110 120 130 140 150
EGLKNVTSGA NPMVIRKGIE KATQVAVEEL SKISKPIEGK DSIAQVAAIS
160 170 180 190 200
SADDEVGKII AEAMERVGND GVITIEESKG FSTELEVVEG MQFDRGYASP
210 220 230 240 250
YMVTDSDKME AVLDNPYVLI TDKKISNIQE VLPVLEQVVQ QGKPILIIAE
260 270 280 290 300
DVEGEALATL VVNKLRGTFN AVAVKAPGFG DRRKAMLEDI AILTGGEVIT
310 320 330 340 350
EDLGLDLKSA NITQLGRASK VVVTKENTTI VEGAGESDKI AARVNQIKAQ
360 370 380 390 400
IEETTSDFDK EKLQERLAKL AGGVAVLKVG AATETEMKER KLRIEDALNS
410 420 430 440 450
TRAAVEEGIV AGGGTALVNV IKAVSSIGAE GDEATGVNIV LRALEEPVRQ
460 470 480 490 500
IAHNAGLEGS VIVERLKKEE AGFGFNAATG EWVNMVEAGI VDPTKVTRSA
510 520 530 540
LQHAASVSAM FLTTEAVIAD KPEENEGGGG MPDMGGMGGM GGMM
Length:544
Mass (Da):57,404
Last modified:December 1, 2000 - v2
Checksum:iC769ED81C903C971
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti407 – 4071E → VK in BAA09494 (PubMed:8987660).Curated
Sequence conflicti421 – 4211Missing in BAA09494 (PubMed:8987660).Curated
Sequence conflicti500 – 5001A → VP in BAA09494 (PubMed:8987660).Curated
Sequence conflicti512 – 5121Missing in BAA09494 (PubMed:8987660).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D55630 Genomic DNA. Translation: BAA09494.1.
BA000004 Genomic DNA. Translation: BAB04281.1.
PIRiB83720.
JC5130.
RefSeqiWP_010896739.1. NC_002570.2.

Genome annotation databases

EnsemblBacteriaiBAB04281; BAB04281; BAB04281.
KEGGibha:BH0562.
PATRICi18938100. VBIBacHal18977_0593.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D55630 Genomic DNA. Translation: BAA09494.1.
BA000004 Genomic DNA. Translation: BAB04281.1.
PIRiB83720.
JC5130.
RefSeqiWP_010896739.1. NC_002570.2.

3D structure databases

ProteinModelPortaliO50305.
SMRiO50305. Positions 2-526.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272558.BH0562.

Proteomic databases

PRIDEiO50305.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB04281; BAB04281; BAB04281.
KEGGibha:BH0562.
PATRICi18938100. VBIBacHal18977_0593.

Phylogenomic databases

eggNOGiENOG4105CJ9. Bacteria.
COG0459. LUCA.
KOiK04077.
OMAiKKQMDET.
OrthoDBiPOG091H00E7.

Enzyme and pathway databases

BioCyciBHAL272558:GJC5-615-MONOMER.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiIPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiPS00296. CHAPERONINS_CPN60. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCH60_BACHD
AccessioniPrimary (citable) accession number: O50305
Secondary accession number(s): Q9KFC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: December 1, 2000
Last modified: September 7, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.