O50258 (NLR_DESGI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neelaredoxin
EC=1.15.1.1

Alternative name(s):
Superoxide dismutase

Gene names

Name:

nlr

Organism

Desulfovibrio gigas

Taxonomic identifier

879 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Deltaproteobacteria › Desulfovibrionales › Desulfovibrionaceae › Desulfovibrio

Protein attributes

Sequence length	130 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Non-heme iron protein.
Catalytic activity	2 superoxide + 2 H+ = O2 + H2O2.
Cofactor	Binds 2 iron ions per subunit.
Subunit structure	Monomer.
Miscellaneous	Has a reduction potential of +190 mV.
Sequence similarities	Belongs to the desulfoferrodoxin family.

Ontologies

Keywords
Biological process	Electron transport Transport
Ligand	Iron Metal-binding
Molecular function	Oxidoreductase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	iron ion binding Inferred from electronic annotation. Source: InterPro superoxide dismutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 130	130	Neelaredoxin		PRO_0000140869
Sites
	Metal binding	15	1	Iron By similarity
	Metal binding	17	1	Iron By similarity
	Metal binding	45	1	Iron By similarity
	Metal binding	51	1	Iron By similarity
	Metal binding	115	1	Iron By similarity
	Metal binding	118	1	Iron By similarity
Experimental info
	Sequence conflict	4	1	C → Y AA sequence Ref.3

Sequences

	Sequence		Length	Mass (Da)
	O50258 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: F0B8E1262CDA4180	FASTA	130	14,523
	10 20 30 40 50 60 MKMCDMFQTA DWKTEKHVPA IECDDAVAAD AFFPVTVSLG KEIAHPNTTE HHIRWIRCYF 70 80 90 100 110 120 KPEGDKFSYE VGSFEFTAHG ECAKGPNEGP VYTNHTVTFQ LKIKTPGVLV ASSFCNIHGL 130 WESSKAVALK

References

[1]	Shenvi N.V., Kurtz D.M. Jr. Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Desulfovibrio gigas neelaredoxin. A novel superoxide dismutase integrated in a putative oxygen sensory operon of an anaerobe." Silva G., Oliveira S., Gomes C.M., Pacheco I., Liu M.Y., Xavier A.V., Teixeira M., LeGall J., Rodrigues-Pousada C. Eur. J. Biochem. 259:235-243(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION. Strain: ATCC 19364 / DSM 1382 / NCIB 9332 / VKM B-1759.
[3]	"A blue non-heme iron protein from Desulfovibrio gigas." Chen L., Sharma P., le Gall J., Mariano A.M., Teixeira M., Xavier A.V. Eur. J. Biochem. 226:613-618(1994) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-28. Strain: ATCC 19364 / DSM 1382 / NCIB 9332 / VKM B-1759.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF034965 Genomic DNA. Translation: AAB87989.1. AF096317 Genomic DNA. Translation: AAD13200.1.
3D structure databases
ProteinModelPortal	O50258.
SMR	O50258. Positions 1-130.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR002742. Desulfoferrodoxin_Fe-bd_dom. [Graphical view]
Pfam	PF01880. Desulfoferrodox. 1 hit. [Graphical view]
SUPFAM	SSF49367. Desulfoferrodox. 1 hit.
TIGRFAMs	TIGR00332. neela_ferrous. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NLR_DESGI

Accession

Primary (citable) accession number: O50258

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	June 1, 1998
Last modified:	April 3, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program