Reviewed, UniProtKB/Swiss-Prot O50258 (NLR_DESGI)

Names and origin

Protein names

Recommended name:
    Neelaredoxin
    EC=1.15.1.1
Alternative name(s):
    Superoxide dismutase

Gene names

Name:

nlr

Organism

Desulfovibrio gigas

Taxonomic identifier

879 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Desulfovibrionales › Desulfovibrionaceae › Desulfovibrio

Protein attributes

Sequence length	130 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Non-heme iron protein.
Catalytic activity	2 superoxide + 2 H+ = O2 + H2O2.
Cofactor	Binds 2 iron ions per subunit.
Subunit structure	Monomer.
Miscellaneous	Has a reduction potential of +190 mV.
Sequence similarities	Belongs to the desulfoferrodoxin family.

Ontologies

Keywords
Biological process	Electron transport Transport
Ligand	Iron Metal-binding
Molecular function	Oxidoreductase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW superoxide dismutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 130	130	Neelaredoxin		PRO_0000140869
Sites
	Metal binding	15	1	Iron By similarity
	Metal binding	17	1	Iron By similarity
	Metal binding	45	1	Iron By similarity
	Metal binding	51	1	Iron By similarity
	Metal binding	115	1	Iron By similarity
	Metal binding	118	1	Iron By similarity
Experimental info
	Sequence conflict	4	1	C → Y AA sequence Ref.3

Sequences

	Sequence		Length	Mass (Da)
	O50258-1 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: F0B8E1262CDA4180	FASTA	130	14,523
	10 20 30 40 50 60 MKMCDMFQTA DWKTEKHVPA IECDDAVAAD AFFPVTVSLG KEIAHPNTTE HHIRWIRCYF 70 80 90 100 110 120 KPEGDKFSYE VGSFEFTAHG ECAKGPNEGP VYTNHTVTFQ LKIKTPGVLV ASSFCNIHGL 130 WESSKAVALK

References

[1]	Shenvi N.V., Kurtz D.M. Jr. Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Desulfovibrio gigas neelaredoxin. A novel superoxide dismutase integrated in a putative oxygen sensory operon of an anaerobe." Silva G., Oliveira S., Gomes C.M., Pacheco I., Liu M.Y., Xavier A.V., Teixeira M., LeGall J., Rodrigues-Pousada C. Eur. J. Biochem. 259:235-243(1999) [PubMed: 9914498] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION. Strain: ATCC 19364 / DSM 1382 / NCIB 9332 / VKM B-1759.
[3]	"A blue non-heme iron protein from Desulfovibrio gigas." Chen L., Sharma P., le Gall J., Mariano A.M., Teixeira M., Xavier A.V. Eur. J. Biochem. 226:613-618(1994) [PubMed: 8001576] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-28. Strain: ATCC 19364 / DSM 1382 / NCIB 9332 / VKM B-1759.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF034965 Genomic DNA. Translation: AAB87989.1. AF096317 Genomic DNA. Translation: AAD13200.1.
3D structure databases
HSSP	HSSP built from PDB template 1DQI based on UniProtKB P82385.
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.15.1.1. 7582.
Family and domain databases
InterPro	IPR002742. Desulfoferrodoxin_Fe-bd. [Graphical view]
Pfam	PF01880. Desulfoferrodox. 1 hit. [Graphical view]
ProDom	PD006618. Desulfoferrodox. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00332. neela_ferrous. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NLR_DESGI

Accession

Primary (citable) accession number: O50258

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	June 1, 1998
Last modified:	June 16, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)