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O50098 (PANE_PYRHO) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative 2-dehydropantoate 2-reductase

EC=1.1.1.169
Alternative name(s):
Ketopantoate reductase
Short name=KPA reductase
Short name=KPR
Gene names
Ordered Locus Names:PH1390
ORF Names:PHAA019
OrganismPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) [Complete proteome] [HAMAP]
Taxonomic identifier70601 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus

Protein attributes

Sequence length301 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid By similarity.

Catalytic activity

(R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 2/2.

Subcellular location

Cytoplasm Potential.

Sequence similarities

Belongs to the ketopantoate reductase family.

Ontologies

Keywords
   Biological processPantothenate biosynthesis
   Cellular componentCytoplasm
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpantothenate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function2-dehydropantoate 2-reductase activity

Inferred from electronic annotation. Source: UniProtKB-EC

NADP binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 301301Putative 2-dehydropantoate 2-reductase
PRO_0000157326

Regions

Nucleotide binding7 – 126NADP By similarity

Sites

Active site1791Proton donor By similarity
Binding site991NADP; via amide nitrogen By similarity
Binding site991Substrate By similarity
Binding site1831Substrate By similarity
Binding site1871Substrate By similarity
Binding site2491Substrate By similarity
Binding site2611NADP By similarity

Sequences

Sequence LengthMass (Da)Tools
O50098 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: E2354787F603880C

FASTA30132,811
        10         20         30         40         50         60 
MKIYILGAGA IGSLVGGLLA NVGEDVTLIG RGRHIEAINK RGLMIEGLTN LKINTKATTS 

        70         80         90        100        110        120 
IPGAKPDLII LTTKSYSTDD ALNSAKDIVR DTWVLSLQNG IGNEEKIMEL GGRPIGGITT 

       130        140        150        160        170        180 
NGAVLKEPGV VEWRGRGITL IGLYPKGRNE FVEEVKETFN RAGLETEVTE NIIGWKWAKT 

       190        200        210        220        230        240 
IVNSAINPIG AILEVKNGAI KDNDYLLSIA VEVVKEGCKI ALQNGIKFDI SPMELLIQTL 

       250        260        270        280        290        300 
EQTRENYNSM LQDIWRGKRT EIDFINGKII EYAKLVNLEA PLNFLLWALV KAKESLGGGS 


K 

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References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000001 Genomic DNA. Translation: BAA30496.1.
PIRH71011.
RefSeqNP_143268.1. NC_000961.1.

3D structure databases

ProteinModelPortalO50098.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING70601.PH1390.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA30496; BAA30496; BAA30496.
GeneID1443716.
KEGGpho:PH1390.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1893.
HOGENOMHOG000050222.
KOK00077.
OMAIDDDRGE.
ProtClustDBPRK06522.

Enzyme and pathway databases

BioCycPHOR70601:GJWR-1396-MONOMER.
UniPathwayUPA00028; UER00004.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR003710. ApbA.
IPR013752. ApbA_C.
IPR013332. ApbA_N.
IPR013328. DH_multihelical.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view]
SUPFAMSSF48179. SSF48179. 1 hit.
TIGRFAMsTIGR00745. apbA_panE. 1 hit.
ProtoNetSearch...

Entry information

Entry namePANE_PYRHO
AccessionPrimary (citable) accession number: O50098
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: October 16, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways