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O49954 (GCSP_SOLTU) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating), mitochondrial

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:GDCSP
OrganismSolanum tuberosum (Potato) [Reference proteome]
Taxonomic identifier4113 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanum

Protein attributes

Sequence length1035 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate.

Subunit structure

Homodimer By similarity. The glycine cleavage system is composed of four proteins: P, T, L and H. HAMAP-Rule MF_00711

Subcellular location

Mitochondrion HAMAP-Rule MF_00711.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Keywords
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandPyridoxal phosphate
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglycine catabolic process

Inferred from electronic annotation. Source: InterPro

response to cadmium ion

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

   Cellular_componentapoplast

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

chloroplast envelope

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

chloroplast stroma

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

chloroplast thylakoid

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

mitochondrion

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

glycine dehydrogenase (decarboxylating) activity

Inferred from electronic annotation. Source: UniProtKB-EC

pyridoxal phosphate binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 6464Mitochondrion Potential
Chain65 – 1035971Glycine dehydrogenase (decarboxylating), mitochondrial HAMAP-Rule MF_00711
PRO_0000010750

Amino acid modifications

Modified residue7711N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
O49954 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 76C8418ED1856AFB

FASTA1,035112,914
        10         20         30         40         50         60 
MERARKLANR AILKRLVSQS KQSRSNEIPS SSLYRPSRYV SSLSPYTFQA RNNAKSFNTQ 

        70         80         90        100        110        120 
QARSISVEAL KPSDTFPRRH NSATPEEQTK MAEFCGFQSL DALIDATVPQ SIRSESMKLP 

       130        140        150        160        170        180 
KFDSGLTESQ MIEHMQNLAS KNKVFKSYIG MGYYNTYVPP VILRNLLENP AWYTQYTPYQ 

       190        200        210        220        230        240 
AEISQGRLES LLNYQTMITD LTGLPMSNAS LLDEGTAAAE AMAMCNNILK GKKKTFLIAS 

       250        260        270        280        290        300 
NCHPQTIDIC KTRADGFDLK VVTVDLKDID YKSGDVCGVL VQYPGTEGEI LDYGEFIKNA 

       310        320        330        340        350        360 
HAHGVKVVMA SDLLALTMLK PPGELGADIV VGSAQRFGVP MGYGGPHAAF LATSQEYKRM 

       370        380        390        400        410        420 
MPGRIIGLSV DSTGKPALRM AMQTREQHIR RDKATSNICT AQALLANMAA MYAVYHGPEG 

       430        440        450        460        470        480 
LKTIGQRVHG LAGTFSAGLK KLGTVEVQDL PFFDTVKVKC SDAKAIADVA NKNDINLRIV 

       490        500        510        520        530        540 
DNNTITVSFD ETTTLEDVDD LFKVFALGKP VPFTAQSIAQ EVENLIPSGL TRETPFLTHQ 

       550        560        570        580        590        600 
IFNSYHTEHE LLRYLHKLQS KDLSLCHSMI PLGSCTMKLN ATTEMMPVTW PSFANIHPFA 

       610        620        630        640        650        660 
PTEQAAGYQE MFDDLGALLC TITGFDSFSL QPNAGAAGEY AGLMVIRAYH MSRGDHHRNV 

       670        680        690        700        710        720 
CIIPVSAHGT NPASAAMCGM KIVAVGTDAK GNINIEELRK AAEANKDNLA ALMVTYPSTH 

       730        740        750        760        770        780 
GVYEEGIDEI CKIIHDNGGQ VYMDGANMNA QVGLTSPGFI GADVCHLNLH KTFCIPHGGG 

       790        800        810        820        830        840 
GPGMGPIGVK KHLAPYLPSH PVVPTGGIPS PDKSEPLGAI SAAPWGSALI LPISYTYIAM 

       850        860        870        880        890        900 
MGSKGLTDAS KIAILSANYM AKRLEKHYPV LFRGVNGTCA HEFIIDLRGF KNTAGIEPED 

       910        920        930        940        950        960 
VAKRLIDYGF HGPTMSWPVP GTLMIEPTES ESKAELDRFC DALISIREEI AQIEKGNVDI 

       970        980        990       1000       1010       1020 
NNNVLKGAPH PPSMLMADAW TKPYSREYAA YPAPWLRSAK FWPTTGRVDN VYGDRNLICT 

      1030 
LLPVSEMAEE KAATA 

« Hide

References

[1]"cDNA encoding P-protein of the glycine cleavage system in Solanum tuberosum Cv. Desire."
Bauwe H.
Plant Gene Register PGR98-005
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. Desiree.
Tissue: Leaf.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z99770 mRNA. Translation: CAB16918.1.
PIRT07826.
UniGeneStu.1064.

3D structure databases

ProteinModelPortalO49954.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActO49954. 1 interaction.

Proteomic databases

PRIDEO49954.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_SOLTU
AccessionPrimary (citable) accession number: O49954
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 1, 1998
Last modified: March 19, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families