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O49954

- GCSP_SOLTU

UniProt

O49954 - GCSP_SOLTU

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Protein

Glycine dehydrogenase (decarboxylating), mitochondrial

Gene

GDCSP

Organism
Solanum tuberosum (Potato)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.

Cofactori

Pyridoxal phosphate.

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating), mitochondrial (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:GDCSP
OrganismiSolanum tuberosum (Potato)
Taxonomic identifieri4113 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanum
ProteomesiUP000011115: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 6464MitochondrionSequence AnalysisAdd
BLAST
Chaini65 – 1035971Glycine dehydrogenase (decarboxylating), mitochondrialPRO_0000010750Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei771 – 7711N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

PRIDEiO49954.

Interactioni

Subunit structurei

Homodimer (By similarity). The glycine cleavage system is composed of four proteins: P, T, L and H.By similarity

Protein-protein interaction databases

IntActiO49954. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliO49954.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

InParanoidiO49954.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O49954-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MERARKLANR AILKRLVSQS KQSRSNEIPS SSLYRPSRYV SSLSPYTFQA
60 70 80 90 100
RNNAKSFNTQ QARSISVEAL KPSDTFPRRH NSATPEEQTK MAEFCGFQSL
110 120 130 140 150
DALIDATVPQ SIRSESMKLP KFDSGLTESQ MIEHMQNLAS KNKVFKSYIG
160 170 180 190 200
MGYYNTYVPP VILRNLLENP AWYTQYTPYQ AEISQGRLES LLNYQTMITD
210 220 230 240 250
LTGLPMSNAS LLDEGTAAAE AMAMCNNILK GKKKTFLIAS NCHPQTIDIC
260 270 280 290 300
KTRADGFDLK VVTVDLKDID YKSGDVCGVL VQYPGTEGEI LDYGEFIKNA
310 320 330 340 350
HAHGVKVVMA SDLLALTMLK PPGELGADIV VGSAQRFGVP MGYGGPHAAF
360 370 380 390 400
LATSQEYKRM MPGRIIGLSV DSTGKPALRM AMQTREQHIR RDKATSNICT
410 420 430 440 450
AQALLANMAA MYAVYHGPEG LKTIGQRVHG LAGTFSAGLK KLGTVEVQDL
460 470 480 490 500
PFFDTVKVKC SDAKAIADVA NKNDINLRIV DNNTITVSFD ETTTLEDVDD
510 520 530 540 550
LFKVFALGKP VPFTAQSIAQ EVENLIPSGL TRETPFLTHQ IFNSYHTEHE
560 570 580 590 600
LLRYLHKLQS KDLSLCHSMI PLGSCTMKLN ATTEMMPVTW PSFANIHPFA
610 620 630 640 650
PTEQAAGYQE MFDDLGALLC TITGFDSFSL QPNAGAAGEY AGLMVIRAYH
660 670 680 690 700
MSRGDHHRNV CIIPVSAHGT NPASAAMCGM KIVAVGTDAK GNINIEELRK
710 720 730 740 750
AAEANKDNLA ALMVTYPSTH GVYEEGIDEI CKIIHDNGGQ VYMDGANMNA
760 770 780 790 800
QVGLTSPGFI GADVCHLNLH KTFCIPHGGG GPGMGPIGVK KHLAPYLPSH
810 820 830 840 850
PVVPTGGIPS PDKSEPLGAI SAAPWGSALI LPISYTYIAM MGSKGLTDAS
860 870 880 890 900
KIAILSANYM AKRLEKHYPV LFRGVNGTCA HEFIIDLRGF KNTAGIEPED
910 920 930 940 950
VAKRLIDYGF HGPTMSWPVP GTLMIEPTES ESKAELDRFC DALISIREEI
960 970 980 990 1000
AQIEKGNVDI NNNVLKGAPH PPSMLMADAW TKPYSREYAA YPAPWLRSAK
1010 1020 1030
FWPTTGRVDN VYGDRNLICT LLPVSEMAEE KAATA
Length:1,035
Mass (Da):112,914
Last modified:June 1, 1998 - v1
Checksum:i76C8418ED1856AFB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z99770 mRNA. Translation: CAB16918.1.
PIRiT07826.
UniGeneiStu.1064.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z99770 mRNA. Translation: CAB16918.1 .
PIRi T07826.
UniGenei Stu.1064.

3D structure databases

ProteinModelPortali O49954.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O49954. 1 interaction.

Proteomic databases

PRIDEi O49954.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

InParanoidi O49954.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "cDNA encoding P-protein of the glycine cleavage system in Solanum tuberosum Cv. Desire."
    Bauwe H.
    Plant Gene Register PGR98-005
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Desiree.
    Tissue: Leaf.

Entry informationi

Entry nameiGCSP_SOLTU
AccessioniPrimary (citable) accession number: O49954
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 1, 1998
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3