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O49954

- GCSP_SOLTU

UniProt

O49954 - GCSP_SOLTU

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Protein
Glycine dehydrogenase (decarboxylating), mitochondrial
Gene
GDCSP
Organism
Solanum tuberosum (Potato)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.

GO - Molecular functioni

  1. ATP binding Source: EnsemblPlants/Gramene
  2. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  3. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. response to cadmium ion Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating), mitochondrial (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:GDCSP
OrganismiSolanum tuberosum (Potato)
Taxonomic identifieri4113 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanum
ProteomesiUP000011115: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. apoplast Source: EnsemblPlants/Gramene
  2. chloroplast envelope Source: EnsemblPlants/Gramene
  3. chloroplast stroma Source: EnsemblPlants/Gramene
  4. chloroplast thylakoid Source: EnsemblPlants/Gramene
  5. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 6464Mitochondrion Reviewed prediction
Add
BLAST
Chaini65 – 1035971Glycine dehydrogenase (decarboxylating), mitochondrialUniRule annotation
PRO_0000010750Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei771 – 7711N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PRIDEiO49954.

Interactioni

Subunit structurei

Homodimer By similarity. The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

IntActiO49954. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliO49954.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Keywords - Domaini

Transit peptide

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O49954-1 [UniParc]FASTAAdd to Basket

« Hide

MERARKLANR AILKRLVSQS KQSRSNEIPS SSLYRPSRYV SSLSPYTFQA     50
RNNAKSFNTQ QARSISVEAL KPSDTFPRRH NSATPEEQTK MAEFCGFQSL 100
DALIDATVPQ SIRSESMKLP KFDSGLTESQ MIEHMQNLAS KNKVFKSYIG 150
MGYYNTYVPP VILRNLLENP AWYTQYTPYQ AEISQGRLES LLNYQTMITD 200
LTGLPMSNAS LLDEGTAAAE AMAMCNNILK GKKKTFLIAS NCHPQTIDIC 250
KTRADGFDLK VVTVDLKDID YKSGDVCGVL VQYPGTEGEI LDYGEFIKNA 300
HAHGVKVVMA SDLLALTMLK PPGELGADIV VGSAQRFGVP MGYGGPHAAF 350
LATSQEYKRM MPGRIIGLSV DSTGKPALRM AMQTREQHIR RDKATSNICT 400
AQALLANMAA MYAVYHGPEG LKTIGQRVHG LAGTFSAGLK KLGTVEVQDL 450
PFFDTVKVKC SDAKAIADVA NKNDINLRIV DNNTITVSFD ETTTLEDVDD 500
LFKVFALGKP VPFTAQSIAQ EVENLIPSGL TRETPFLTHQ IFNSYHTEHE 550
LLRYLHKLQS KDLSLCHSMI PLGSCTMKLN ATTEMMPVTW PSFANIHPFA 600
PTEQAAGYQE MFDDLGALLC TITGFDSFSL QPNAGAAGEY AGLMVIRAYH 650
MSRGDHHRNV CIIPVSAHGT NPASAAMCGM KIVAVGTDAK GNINIEELRK 700
AAEANKDNLA ALMVTYPSTH GVYEEGIDEI CKIIHDNGGQ VYMDGANMNA 750
QVGLTSPGFI GADVCHLNLH KTFCIPHGGG GPGMGPIGVK KHLAPYLPSH 800
PVVPTGGIPS PDKSEPLGAI SAAPWGSALI LPISYTYIAM MGSKGLTDAS 850
KIAILSANYM AKRLEKHYPV LFRGVNGTCA HEFIIDLRGF KNTAGIEPED 900
VAKRLIDYGF HGPTMSWPVP GTLMIEPTES ESKAELDRFC DALISIREEI 950
AQIEKGNVDI NNNVLKGAPH PPSMLMADAW TKPYSREYAA YPAPWLRSAK 1000
FWPTTGRVDN VYGDRNLICT LLPVSEMAEE KAATA 1035
Length:1,035
Mass (Da):112,914
Last modified:June 1, 1998 - v1
Checksum:i76C8418ED1856AFB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z99770 mRNA. Translation: CAB16918.1.
PIRiT07826.
UniGeneiStu.1064.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z99770 mRNA. Translation: CAB16918.1 .
PIRi T07826.
UniGenei Stu.1064.

3D structure databases

ProteinModelPortali O49954.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O49954. 1 interaction.

Proteomic databases

PRIDEi O49954.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "cDNA encoding P-protein of the glycine cleavage system in Solanum tuberosum Cv. Desire."
    Bauwe H.
    Plant Gene Register PGR98-005
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Desiree.
    Tissue: Leaf.

Entry informationi

Entry nameiGCSP_SOLTU
AccessioniPrimary (citable) accession number: O49954
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 1, 1998
Last modified: March 19, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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