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O49954

- GCSP_SOLTU

UniProt

O49954 - GCSP_SOLTU

Protein

Glycine dehydrogenase (decarboxylating), mitochondrial

Gene

GDCSP

Organism
Solanum tuberosum (Potato)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.

    Cofactori

    Pyridoxal phosphate.

    GO - Molecular functioni

    1. ATP binding Source: EnsemblPlants/Gramene
    2. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    3. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine catabolic process Source: InterPro
    2. response to cadmium ion Source: EnsemblPlants/Gramene

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating), mitochondrial (EC:1.4.4.2)
    Alternative name(s):
    Glycine cleavage system P protein
    Glycine decarboxylase
    Glycine dehydrogenase (aminomethyl-transferring)
    Gene namesi
    Name:GDCSP
    OrganismiSolanum tuberosum (Potato)
    Taxonomic identifieri4113 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanum
    ProteomesiUP000011115: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. apoplast Source: EnsemblPlants/Gramene
    2. chloroplast envelope Source: EnsemblPlants/Gramene
    3. chloroplast stroma Source: EnsemblPlants/Gramene
    4. chloroplast thylakoid Source: EnsemblPlants/Gramene
    5. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 6464MitochondrionSequence AnalysisAdd
    BLAST
    Chaini65 – 1035971Glycine dehydrogenase (decarboxylating), mitochondrialPRO_0000010750Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei771 – 7711N6-(pyridoxal phosphate)lysineBy similarity

    Proteomic databases

    PRIDEiO49954.

    Interactioni

    Subunit structurei

    Homodimer By similarity. The glycine cleavage system is composed of four proteins: P, T, L and H.By similarity

    Protein-protein interaction databases

    IntActiO49954. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliO49954.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.Curated

    Keywords - Domaini

    Transit peptide

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O49954-1 [UniParc]FASTAAdd to Basket

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    MERARKLANR AILKRLVSQS KQSRSNEIPS SSLYRPSRYV SSLSPYTFQA     50
    RNNAKSFNTQ QARSISVEAL KPSDTFPRRH NSATPEEQTK MAEFCGFQSL 100
    DALIDATVPQ SIRSESMKLP KFDSGLTESQ MIEHMQNLAS KNKVFKSYIG 150
    MGYYNTYVPP VILRNLLENP AWYTQYTPYQ AEISQGRLES LLNYQTMITD 200
    LTGLPMSNAS LLDEGTAAAE AMAMCNNILK GKKKTFLIAS NCHPQTIDIC 250
    KTRADGFDLK VVTVDLKDID YKSGDVCGVL VQYPGTEGEI LDYGEFIKNA 300
    HAHGVKVVMA SDLLALTMLK PPGELGADIV VGSAQRFGVP MGYGGPHAAF 350
    LATSQEYKRM MPGRIIGLSV DSTGKPALRM AMQTREQHIR RDKATSNICT 400
    AQALLANMAA MYAVYHGPEG LKTIGQRVHG LAGTFSAGLK KLGTVEVQDL 450
    PFFDTVKVKC SDAKAIADVA NKNDINLRIV DNNTITVSFD ETTTLEDVDD 500
    LFKVFALGKP VPFTAQSIAQ EVENLIPSGL TRETPFLTHQ IFNSYHTEHE 550
    LLRYLHKLQS KDLSLCHSMI PLGSCTMKLN ATTEMMPVTW PSFANIHPFA 600
    PTEQAAGYQE MFDDLGALLC TITGFDSFSL QPNAGAAGEY AGLMVIRAYH 650
    MSRGDHHRNV CIIPVSAHGT NPASAAMCGM KIVAVGTDAK GNINIEELRK 700
    AAEANKDNLA ALMVTYPSTH GVYEEGIDEI CKIIHDNGGQ VYMDGANMNA 750
    QVGLTSPGFI GADVCHLNLH KTFCIPHGGG GPGMGPIGVK KHLAPYLPSH 800
    PVVPTGGIPS PDKSEPLGAI SAAPWGSALI LPISYTYIAM MGSKGLTDAS 850
    KIAILSANYM AKRLEKHYPV LFRGVNGTCA HEFIIDLRGF KNTAGIEPED 900
    VAKRLIDYGF HGPTMSWPVP GTLMIEPTES ESKAELDRFC DALISIREEI 950
    AQIEKGNVDI NNNVLKGAPH PPSMLMADAW TKPYSREYAA YPAPWLRSAK 1000
    FWPTTGRVDN VYGDRNLICT LLPVSEMAEE KAATA 1035
    Length:1,035
    Mass (Da):112,914
    Last modified:June 1, 1998 - v1
    Checksum:i76C8418ED1856AFB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z99770 mRNA. Translation: CAB16918.1.
    PIRiT07826.
    UniGeneiStu.1064.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z99770 mRNA. Translation: CAB16918.1 .
    PIRi T07826.
    UniGenei Stu.1064.

    3D structure databases

    ProteinModelPortali O49954.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O49954. 1 interaction.

    Proteomic databases

    PRIDEi O49954.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "cDNA encoding P-protein of the glycine cleavage system in Solanum tuberosum Cv. Desire."
      Bauwe H.
      Plant Gene Register PGR98-005
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Desiree.
      Tissue: Leaf.

    Entry informationi

    Entry nameiGCSP_SOLTU
    AccessioniPrimary (citable) accession number: O49954
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3