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Protein

Phosphoinositide phospholipase C

Gene

plc3

Organism
Solanum tuberosum (Potato)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationImported, TransducerSAAS annotation

Keywords - Biological processi

Lipid degradationUniRule annotation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide phospholipase CUniRule annotation (EC:3.1.4.11UniRule annotation)
Gene namesi
Name:plc3Imported
OrganismiSolanum tuberosum (Potato)Imported
Taxonomic identifieri4113 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanum

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi4113.PGSC0003DMT400069760.

Structurei

3D structure databases

ProteinModelPortaliO49952.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini109 – 252144PI-PLC X-boxInterPro annotationAdd
BLAST
Domaini350 – 43687PI-PLC Y-boxInterPro annotationAdd
BLAST
Domaini443 – 550108C2InterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C2 domain.UniRule annotation
Contains 1 PI-PLC X-box domain.UniRule annotation
Contains 1 PI-PLC Y-box domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG0169. Eukaryota.
ENOG410XPSW. LUCA.
KOiK05857.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR001192. PI-PLC_fam.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLC_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 1 hit.
PfamiPF00168. C2. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
[Graphical view]
PRINTSiPR00390. PHPHLIPASEC.
SMARTiSM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O49952-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKQSYRVCF CFRRRFRVLA AEAPADVKNL FNRYSDNGVM SAENLHRFLI
60 70 80 90 100
EVQKEENATL EDAHAIMNNL HDLKILNIFH RRGLHLDAFF KYLFADINPP
110 120 130 140 150
LNSKLGIHQD MNAPLSHYFI YTGHNSYLTG NQLSSDCSDV PIIQALHRGV
160 170 180 190 200
RVIELDIWPN SAKDDVEVLH GGTLTTPVAL IKCLKSIKEH AFTVSEYPVV
210 220 230 240 250
ITLEDHLTTD LQAKTAEMIT QTFGDMLFSS DSCLKEFPSP ESLKRRVLIS
260 270 280 290 300
TKPPKEYLQA KEVNETGAMK GTDQTDTEAW GREVSDIKAR YNDKDDSDEG
310 320 330 340 350
EADDSDEEDP TSQQNTAPEY RRLIAIHAGK GKGGLSDWLR VDPDKVRRLS
360 370 380 390 400
LSEQELGKAV VTHGKEIIRF TQRNILRIYP KGIRFDSSNY NPFNAWTHGA
410 420 430 440 450
QMVAFNMQGY GRSLWLMHGM FRGNGGCGYV KKPDILLKAG PNNEVFDPEA
460 470 480 490 500
NLPVKTTLKV TVFMGEGWYY DFEHTHFDAY SPPDFYARIG IAGVDADIVM
510 520 530 540 550
KKTKTLEDNW IPTWDEQFEF PLTVPELALL RVEVHEYDMS EKDDFAGQTC
560 570 580
LPVSELRQGI RAVPLHNRKG EKYNSVKLLL RFEFI
Length:585
Mass (Da):66,610
Last modified:June 1, 1998 - v1
Checksum:i9AC15C36F7A3544C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94289 mRNA. Translation: CAA63954.1.
PIRiT07425.
RefSeqiNP_001275400.1. NM_001288471.1.
UniGeneiStu.18570.

Genome annotation databases

GeneIDi102588383.
KEGGisot:102588383.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94289 mRNA. Translation: CAA63954.1.
PIRiT07425.
RefSeqiNP_001275400.1. NM_001288471.1.
UniGeneiStu.18570.

3D structure databases

ProteinModelPortaliO49952.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4113.PGSC0003DMT400069760.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi102588383.
KEGGisot:102588383.

Phylogenomic databases

eggNOGiKOG0169. Eukaryota.
ENOG410XPSW. LUCA.
KOiK05857.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR001192. PI-PLC_fam.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLC_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 1 hit.
PfamiPF00168. C2. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
[Graphical view]
PRINTSiPR00390. PHPHLIPASEC.
SMARTiSM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO49952_SOLTU
AccessioniPrimary (citable) accession number: O49952
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: September 7, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.