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Protein

Adenosine kinase

Gene

ADK

Organism
Physcomitrella patens subsp. patens (Moss)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Can also act on the cytokinin isopentenyladenosine to produce isopentenyladenosine monophosphate.1 Publication

Catalytic activityi

ATP + adenosine = ADP + AMP.

Cofactori

Mg2+By similarity

Pathwayi: AMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes AMP from adenosine.
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosine kinase (ADK)
This subpathway is part of the pathway AMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes AMP from adenosine, the pathway AMP biosynthesis via salvage pathway and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei296By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processPurine salvage
LigandATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00588; UER00659.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine kinase (EC:2.7.1.20)
Short name:
AK
Alternative name(s):
Adenosine 5'-phosphotransferase
Gene namesi
Name:ADK
ORF Names:PHYPADRAFT_184505
OrganismiPhyscomitrella patens subsp. patens (Moss)
Taxonomic identifieri3218 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaBryophytaBryophytinaBryopsidaFunariidaeFunarialesFunariaceaePhyscomitrella
Proteomesi
  • UP000006727 Componenti: Partially assembled WGS sequence

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000800591 – 343Adenosine kinaseAdd BLAST343

Proteomic databases

PRIDEiO49923.

Interactioni

Protein-protein interaction databases

STRINGi3218.PP1S74_140V6.1.

Structurei

3D structure databases

ProteinModelPortaliO49923.
SMRiO49923.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the carbohydrate kinase PfkB family.Curated

Phylogenomic databases

eggNOGiKOG2854. Eukaryota.
COG0524. LUCA.
HOGENOMiHOG000172419.
InParanoidiO49923.
KOiK00856.
OMAiIKIAQWM.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
InterProiView protein in InterPro
IPR001805. Adenokinase.
IPR002173. Carboh/pur_kinase_PfkB_CS.
IPR011611. PfkB_dom.
IPR029056. Ribokinase-like.
PANTHERiPTHR10584:SF224. PTHR10584:SF224. 1 hit.
PfamiView protein in Pfam
PF00294. PfkB. 1 hit.
PRINTSiPR00989. ADENOKINASE.
SUPFAMiSSF53613. SSF53613. 1 hit.
PROSITEiView protein in PROSITE
PS00584. PFKB_KINASES_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O49923-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASEGVLLGM GNPLLDISCV VDDAFLEKYG LTLNNAILAE DKHLPMYKEL
60 70 80 90 100
AANPDVEYIA GGATQNTIRI AQWMLGESNA TSYFGCVGKD EYGDRMFKLA
110 120 130 140 150
SEGGVNIRYD VDEDLPTGTC GVLVVKGERS LVANLSAANK YKIDHLKKPE
160 170 180 190 200
NWAFVEKAKY IYSAGFFLTV SPESMMTVAK HAAETGKYYM INLAAPFICQ
210 220 230 240 250
FFKDPLMELF PYVDFIFGNE SEARAFAQVQ GWETEDTKVI AVKLAALPKA
260 270 280 290 300
GGTHKRVAVI TQGTDPTIVA EDGKVTEFPV TPIPKEKLVD TNAAGDSFVG
310 320 330 340
GFLSQLVLGK DIAQCVRAGN YAASVIIQRS GCTFPSKPSF ESQ
Length:343
Mass (Da):37,251
Last modified:June 1, 1998 - v1
Checksum:iE29FEC383795E543
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15430 mRNA. Translation: CAA75628.1.
DS544963 Genomic DNA. Translation: EDQ69929.1.
RefSeqiXP_001765201.1. XM_001765149.1.
UniGeneiPpa.45.

Genome annotation databases

EnsemblPlantsiPP1S74_140V6.1; PP1S74_140V6.1; PP1S74_140V6.
GeneIDi5928421.
GrameneiPP1S74_140V6.1; PP1S74_140V6.1; PP1S74_140V6.
KEGGippp:PHYPADRAFT_184505.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15430 mRNA. Translation: CAA75628.1.
DS544963 Genomic DNA. Translation: EDQ69929.1.
RefSeqiXP_001765201.1. XM_001765149.1.
UniGeneiPpa.45.

3D structure databases

ProteinModelPortaliO49923.
SMRiO49923.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3218.PP1S74_140V6.1.

Proteomic databases

PRIDEiO49923.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiPP1S74_140V6.1; PP1S74_140V6.1; PP1S74_140V6.
GeneIDi5928421.
GrameneiPP1S74_140V6.1; PP1S74_140V6.1; PP1S74_140V6.
KEGGippp:PHYPADRAFT_184505.

Phylogenomic databases

eggNOGiKOG2854. Eukaryota.
COG0524. LUCA.
HOGENOMiHOG000172419.
InParanoidiO49923.
KOiK00856.
OMAiIKIAQWM.

Enzyme and pathway databases

UniPathwayiUPA00588; UER00659.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
InterProiView protein in InterPro
IPR001805. Adenokinase.
IPR002173. Carboh/pur_kinase_PfkB_CS.
IPR011611. PfkB_dom.
IPR029056. Ribokinase-like.
PANTHERiPTHR10584:SF224. PTHR10584:SF224. 1 hit.
PfamiView protein in Pfam
PF00294. PfkB. 1 hit.
PRINTSiPR00989. ADENOKINASE.
SUPFAMiSSF53613. SSF53613. 1 hit.
PROSITEiView protein in PROSITE
PS00584. PFKB_KINASES_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADK_PHYPA
AccessioniPrimary (citable) accession number: O49923
Secondary accession number(s): A9SFV8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: June 1, 1998
Last modified: June 7, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.