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Protein

Adenosine kinase

Gene

ADK

Organism
Physcomitrella patens subsp. patens (Moss)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Can also act on the cytokinin isopentenyladenosine to produce isopentenyladenosine monophosphate.1 Publication

Catalytic activityi

ATP + adenosine = ADP + AMP.

Cofactori

Mg2+By similarity

Pathwayi: AMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes AMP from adenosine.
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosine kinase (ADK)
This subpathway is part of the pathway AMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes AMP from adenosine, the pathway AMP biosynthesis via salvage pathway and in Purine metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei296 – 2961By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Purine salvage

Keywords - Ligandi

ATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00588; UER00659.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine kinase (EC:2.7.1.20)
Short name:
AK
Alternative name(s):
Adenosine 5'-phosphotransferase
Gene namesi
Name:ADK
ORF Names:PHYPADRAFT_184505
OrganismiPhyscomitrella patens subsp. patens (Moss)
Taxonomic identifieri3218 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaBryophytaBryophytinaBryopsidaFunariidaeFunarialesFunariaceaePhyscomitrella
Proteomesi
  • UP000006727 Componenti: Partially assembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343Adenosine kinasePRO_0000080059Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi3218.PP1S74_140V6.1.

Structurei

3D structure databases

ProteinModelPortaliO49923.
SMRiO49923. Positions 3-341.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the carbohydrate kinase PfkB family.Curated

Phylogenomic databases

eggNOGiKOG2854. Eukaryota.
COG0524. LUCA.
HOGENOMiHOG000172419.
InParanoidiO49923.
KOiK00856.
OMAiIAYSEGH.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
InterProiIPR001805. Adenokinase.
IPR002173. Carboh/pur_kinase_PfkB_CS.
IPR011611. PfkB_dom.
IPR029056. Ribokinase-like.
[Graphical view]
PANTHERiPTHR10584:SF198. PTHR10584:SF198. 1 hit.
PfamiPF00294. PfkB. 1 hit.
[Graphical view]
PRINTSiPR00989. ADENOKINASE.
SUPFAMiSSF53613. SSF53613. 1 hit.
PROSITEiPS00584. PFKB_KINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O49923-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASEGVLLGM GNPLLDISCV VDDAFLEKYG LTLNNAILAE DKHLPMYKEL
60 70 80 90 100
AANPDVEYIA GGATQNTIRI AQWMLGESNA TSYFGCVGKD EYGDRMFKLA
110 120 130 140 150
SEGGVNIRYD VDEDLPTGTC GVLVVKGERS LVANLSAANK YKIDHLKKPE
160 170 180 190 200
NWAFVEKAKY IYSAGFFLTV SPESMMTVAK HAAETGKYYM INLAAPFICQ
210 220 230 240 250
FFKDPLMELF PYVDFIFGNE SEARAFAQVQ GWETEDTKVI AVKLAALPKA
260 270 280 290 300
GGTHKRVAVI TQGTDPTIVA EDGKVTEFPV TPIPKEKLVD TNAAGDSFVG
310 320 330 340
GFLSQLVLGK DIAQCVRAGN YAASVIIQRS GCTFPSKPSF ESQ
Length:343
Mass (Da):37,251
Last modified:June 1, 1998 - v1
Checksum:iE29FEC383795E543
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15430 mRNA. Translation: CAA75628.1.
DS544963 Genomic DNA. Translation: EDQ69929.1.
RefSeqiXP_001765201.1. XM_001765149.1.
UniGeneiPpa.45.

Genome annotation databases

EnsemblPlantsiPP1S74_140V6.1; PP1S74_140V6.1; PP1S74_140V6.
GeneIDi5928421.
GrameneiPP1S74_140V6.1; PP1S74_140V6.1; PP1S74_140V6.
KEGGippp:PHYPADRAFT_184505.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15430 mRNA. Translation: CAA75628.1.
DS544963 Genomic DNA. Translation: EDQ69929.1.
RefSeqiXP_001765201.1. XM_001765149.1.
UniGeneiPpa.45.

3D structure databases

ProteinModelPortaliO49923.
SMRiO49923. Positions 3-341.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3218.PP1S74_140V6.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiPP1S74_140V6.1; PP1S74_140V6.1; PP1S74_140V6.
GeneIDi5928421.
GrameneiPP1S74_140V6.1; PP1S74_140V6.1; PP1S74_140V6.
KEGGippp:PHYPADRAFT_184505.

Phylogenomic databases

eggNOGiKOG2854. Eukaryota.
COG0524. LUCA.
HOGENOMiHOG000172419.
InParanoidiO49923.
KOiK00856.
OMAiIAYSEGH.

Enzyme and pathway databases

UniPathwayiUPA00588; UER00659.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
InterProiIPR001805. Adenokinase.
IPR002173. Carboh/pur_kinase_PfkB_CS.
IPR011611. PfkB_dom.
IPR029056. Ribokinase-like.
[Graphical view]
PANTHERiPTHR10584:SF198. PTHR10584:SF198. 1 hit.
PfamiPF00294. PfkB. 1 hit.
[Graphical view]
PRINTSiPR00989. ADENOKINASE.
SUPFAMiSSF53613. SSF53613. 1 hit.
PROSITEiPS00584. PFKB_KINASES_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of an adenosine kinase from Physcomitrella involved in cytokinin metabolism."
    von Schwartzenberg K., Kruse S., Reski R., Moffatt B., Laloue M.
    Plant J. 13:249-257(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Strain: Cambridge.
  2. "The Physcomitrella genome reveals evolutionary insights into the conquest of land by plants."
    Rensing S.A., Lang D., Zimmer A.D., Terry A., Salamov A., Shapiro H., Nishiyama T., Perroud P.-F., Lindquist E.A., Kamisugi Y., Tanahashi T., Sakakibara K., Fujita T., Oishi K., Shin-I T., Kuroki Y., Toyoda A., Suzuki Y.
    , Hashimoto S.-I., Yamaguchi K., Sugano A., Kohara Y., Fujiyama A., Anterola A., Aoki S., Ashton N., Barbazuk W.B., Barker E., Bennetzen J.L., Blankenship R., Cho S.H., Dutcher S.K., Estelle M., Fawcett J.A., Gundlach H., Hanada K., Heyl A., Hicks K.A., Hughes J., Lohr M., Mayer K., Melkozernov A., Murata T., Nelson D.R., Pils B., Prigge M., Reiss B., Renner T., Rombauts S., Rushton P.J., Sanderfoot A., Schween G., Shiu S.-H., Stueber K., Theodoulou F.L., Tu H., Van de Peer Y., Verrier P.J., Waters E., Wood A., Yang L., Cove D., Cuming A.C., Hasebe M., Lucas S., Mishler B.D., Reski R., Grigoriev I.V., Quatrano R.S., Boore J.L.
    Science 319:64-69(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Gransden 2004.

Entry informationi

Entry nameiADK_PHYPA
AccessioniPrimary (citable) accession number: O49923
Secondary accession number(s): A9SFV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: June 1, 1998
Last modified: February 17, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.