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Protein

Phosphoinositide phospholipase C

Gene
N/A
Organism
Nicotiana rustica (Aztec tobacco)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationImported, TransducerSAAS annotation

Keywords - Biological processi

Lipid degradationUniRule annotation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide phospholipase CUniRule annotation (EC:3.1.4.11UniRule annotation)
OrganismiNicotiana rustica (Aztec tobacco)Imported
Taxonomic identifieri4093 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Structurei

3D structure databases

ProteinModelPortaliO49902.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini108 – 252145PI-PLC X-boxInterPro annotationAdd
BLAST
Domaini353 – 43987PI-PLC Y-boxInterPro annotationAdd
BLAST
Domaini446 – 553108C2InterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C2 domain.UniRule annotation
Contains 1 PI-PLC X-box domain.UniRule annotation
Contains 1 PI-PLC Y-box domain.UniRule annotation

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR001192. PI-PLC_fam.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 1 hit.
PfamiPF00168. C2. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
[Graphical view]
PRINTSiPR00390. PHPHLIPASEC.
SMARTiSM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O49902-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSYRVCVCF TRKFRVTEAE PPSDVKEAFK KYAENGNQMN SEQLLKFLIE
60 70 80 90 100
VQGETLFTVG DSDVIVRQIL QKRHPITKLT RQTLALEDFH HFLFNTDLNP
110 120 130 140 150
PINYKVHHDM NAPLSHYFIF TGHNSYLTGN QLTSDCSDVP IIKALKKGVR
160 170 180 190 200
VIELDIWPNS DKDDIHVLHG RTVTTPVELI RCLKSIKEHA FVASPYPVVI
210 220 230 240 250
TLEDHLTPDL QAKVAQMLTE TFGEMLFVPE SDSLKECPTP EELKHRIIVS
260 270 280 290 300
TKPPKEYLEA SASTTVSKER RNSSQRSNCS EDDVWGTEPS SLTADQEENE
310 320 330 340 350
KSDSDNFEDE DDCNHRPQFA SAYKRLIAIH AGKPKGGLKE ALKVDPDKVR
360 370 380 390 400
RLSLSEQALE KAAESHGTEI VRFTQRNILR VYPKGTRFNS SNYKPLIGWM
410 420 430 440 450
HGAQMVAFNM QGYGRALWLM HGMFRSNGGC GYVKKPDFLL NVGPNNEVFD
460 470 480 490 500
PKAKLPVKKT LKVKVYMGDG WHLDFKQTHF DLYSPPDFYT RVGIAGVPAD
510 520 530 540 550
EIMKKTKTKE DKWTPVWDEA FTFPLTVPEL ALLRIEVHEY DMSEKDDFAG
560 570 580
QTCIPISELK PGIHAVPLCD RKGEKYSSVR LLMRFEFV
Length:588
Mass (Da):66,942
Last modified:June 1, 1998 - v1
Checksum:iC132712EE2E1220E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11931 mRNA. Translation: CAA72681.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11931 mRNA. Translation: CAA72681.1.

3D structure databases

ProteinModelPortaliO49902.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR001192. PI-PLC_fam.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 1 hit.
PfamiPF00168. C2. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
[Graphical view]
PRINTSiPR00390. PHPHLIPASEC.
SMARTiSM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation of two cDNA clones for phosphoinositide-specific phospholipase C from epidermal peels (accession no. X95877) and guard cells (accession no. Y11931) of Nicotiana rustica (PGR97-086)."
    Pical C., Kopka J., Muller-Rober B., Hetherington A.M., Gray J.E.
    Plant Physiol. 114:748-748(1997)
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiO49902_NICRU
AccessioniPrimary (citable) accession number: O49902
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: May 11, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.