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O49850 (GCSP_FLAAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating), mitochondrial

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:GDCSP
OrganismFlaveria anomala (Yellowtops)
Taxonomic identifier35877 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsAsteralesAsteraceaeAsteroideaeHeliantheae allianceTageteaeFlaveria

Protein attributes

Sequence length1034 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate.

Subunit structure

Homodimer By similarity. The glycine cleavage system is composed of four proteins: P, T, L and H. HAMAP-Rule MF_00711

Subcellular location

Mitochondrion HAMAP-Rule MF_00711.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Keywords
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandPyridoxal phosphate
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processglycine catabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentmitochondrion

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglycine dehydrogenase (decarboxylating) activity

Inferred from electronic annotation. Source: UniProtKB-EC

pyridoxal phosphate binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 6363Mitochondrion Potential
Chain64 – 1034971Glycine dehydrogenase (decarboxylating), mitochondrial HAMAP-Rule MF_00711
PRO_0000010745

Amino acid modifications

Modified residue7701N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
O49850 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: C2F424C76EF104BA

FASTA1,034112,695
        10         20         30         40         50         60 
MERARRLAML GRLVSQTKHN PSISSPALCS PSRYVSSLSP YVCGGTNVRS DRNLNGFGSQ 

        70         80         90        100        110        120 
VRTISVEALK PSDTFPRRHN SATPEEQTKM AEFVGFSNLD SLIDATVPKS IRLDSMKYSK 

       130        140        150        160        170        180 
FDEGLTESQM IAHMQDLASK NKIFKSFIGM GYYNTSVPTV ILRNIMENPG WYTQYTPYQA 

       190        200        210        220        230        240 
EIAQGRLESL LNFQTMITDL TGLPMSNASL LDEGTAAAEA MAMCNNIQKG KKKTFIIASN 

       250        260        270        280        290        300 
CHPQTIDICK TRADGFDLKV VTSDLKDFDY SSGDVCGVLV QYPGTEGELL DYSEFIKNAH 

       310        320        330        340        350        360 
ANGVKVVMAS DLLALTILKP PGELGADIVV GSAQRFGVPM GYGGPHAAFL ATSQEYKRMM 

       370        380        390        400        410        420 
PGRIIGVSVD SSGKPALRMA MQTREQHIRR DKATSNICTA QALLANMAAM YGVYHGPEGL 

       430        440        450        460        470        480 
KTIAKRVHGL AGTFAAGLKK LGTVQVQDLP FFDTVKVTCA DSKAIAEEAC KHKMNLRIVD 

       490        500        510        520        530        540 
KNTITVAFDE TTTIEDVDTL FKVFALGKPV PFTAASIAPE VQDAIPSGLV RETPYLTHPI 

       550        560        570        580        590        600 
FNMYHTEHEL LRYISKLQSK DLSLCHSMIP LGSCTMKLNA TTEMMPVTWP AFADIHPFAP 

       610        620        630        640        650        660 
TEQAQGYQEM FKNLGDLLCT ITGFDSFSLQ PNAGAAGEYA GLMVIRAYHM ARGDHHRNVC 

       670        680        690        700        710        720 
IIPVSAHGTN PASAAMCGMK IITVGTDSKG NINIEELRKA AEANKENLSA LMVTYPSTHG 

       730        740        750        760        770        780 
VYEEGIDEIC KIIHDNGGQV YMDGANMNAQ VGLTSPGWIG ADVCHLNLHK TFCIPHGGGG 

       790        800        810        820        830        840 
PGMGPIGVKK HLAPYLPSHP VVPTGGIPAP EESQPLGTIA AAPWGSALIL PISYTYIAMM 

       850        860        870        880        890        900 
GSQGITNASK IAILNANYMA KRLENHYPIL FRGVNGTVAH EFIVDLRPLK TTAGIEPEDV 

       910        920        930        940        950        960 
AKRLIDYGFH GPTMSWPVPG TLMIEPTESE SKAELDRFCD ALISIRQEIA EIEKGNVDFN 

       970        980        990       1000       1010       1020 
NNVIKGAPHP PQLLMADKWT KPYSREYAAY PAPWLRAAKF WPTTCRVDNV YGDRNLICTL 

      1030 
QPPQEYEEKA EATA 

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References

[1]"The GDCSP gene encoding P-protein of the glycine cleavage system in the C3-C4 intermediate plant Flaveria anomala."
Nan Q., Bauwe H.
Plant Gene Register PGR98-004
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Leaf.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z99762 Genomic DNA. Translation: CAB16911.1.

3D structure databases

ProteinModelPortalO49850.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_FLAAN
AccessionPrimary (citable) accession number: O49850
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 1, 1998
Last modified: February 19, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families