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O49850

- GCSP_FLAAN

UniProt

O49850 - GCSP_FLAAN

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Protein

Glycine dehydrogenase (decarboxylating), mitochondrial

Gene
GDCSP
Organism
Flaveria anomala (Yellowtops)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating), mitochondrial (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:GDCSP
OrganismiFlaveria anomala (Yellowtops)
Taxonomic identifieri35877 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsAsteralesAsteraceaeAsteroideaeHeliantheae allianceTageteaeFlaveria

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 6363Mitochondrion Reviewed predictionAdd
BLAST
Chaini64 – 1034971Glycine dehydrogenase (decarboxylating), mitochondrialUniRule annotationPRO_0000010745Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei770 – 7701N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

Homodimer By similarity. The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliO49850.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Keywords - Domaini

Transit peptide

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O49850-1 [UniParc]FASTAAdd to Basket

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MERARRLAML GRLVSQTKHN PSISSPALCS PSRYVSSLSP YVCGGTNVRS     50
DRNLNGFGSQ VRTISVEALK PSDTFPRRHN SATPEEQTKM AEFVGFSNLD 100
SLIDATVPKS IRLDSMKYSK FDEGLTESQM IAHMQDLASK NKIFKSFIGM 150
GYYNTSVPTV ILRNIMENPG WYTQYTPYQA EIAQGRLESL LNFQTMITDL 200
TGLPMSNASL LDEGTAAAEA MAMCNNIQKG KKKTFIIASN CHPQTIDICK 250
TRADGFDLKV VTSDLKDFDY SSGDVCGVLV QYPGTEGELL DYSEFIKNAH 300
ANGVKVVMAS DLLALTILKP PGELGADIVV GSAQRFGVPM GYGGPHAAFL 350
ATSQEYKRMM PGRIIGVSVD SSGKPALRMA MQTREQHIRR DKATSNICTA 400
QALLANMAAM YGVYHGPEGL KTIAKRVHGL AGTFAAGLKK LGTVQVQDLP 450
FFDTVKVTCA DSKAIAEEAC KHKMNLRIVD KNTITVAFDE TTTIEDVDTL 500
FKVFALGKPV PFTAASIAPE VQDAIPSGLV RETPYLTHPI FNMYHTEHEL 550
LRYISKLQSK DLSLCHSMIP LGSCTMKLNA TTEMMPVTWP AFADIHPFAP 600
TEQAQGYQEM FKNLGDLLCT ITGFDSFSLQ PNAGAAGEYA GLMVIRAYHM 650
ARGDHHRNVC IIPVSAHGTN PASAAMCGMK IITVGTDSKG NINIEELRKA 700
AEANKENLSA LMVTYPSTHG VYEEGIDEIC KIIHDNGGQV YMDGANMNAQ 750
VGLTSPGWIG ADVCHLNLHK TFCIPHGGGG PGMGPIGVKK HLAPYLPSHP 800
VVPTGGIPAP EESQPLGTIA AAPWGSALIL PISYTYIAMM GSQGITNASK 850
IAILNANYMA KRLENHYPIL FRGVNGTVAH EFIVDLRPLK TTAGIEPEDV 900
AKRLIDYGFH GPTMSWPVPG TLMIEPTESE SKAELDRFCD ALISIRQEIA 950
EIEKGNVDFN NNVIKGAPHP PQLLMADKWT KPYSREYAAY PAPWLRAAKF 1000
WPTTCRVDNV YGDRNLICTL QPPQEYEEKA EATA 1034
Length:1,034
Mass (Da):112,695
Last modified:June 1, 1998 - v1
Checksum:iC2F424C76EF104BA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z99762 Genomic DNA. Translation: CAB16911.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z99762 Genomic DNA. Translation: CAB16911.1 .

3D structure databases

ProteinModelPortali O49850.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The GDCSP gene encoding P-protein of the glycine cleavage system in the C3-C4 intermediate plant Flaveria anomala."
    Nan Q., Bauwe H.
    Plant Gene Register PGR98-004
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Leaf.

Entry informationi

Entry nameiGCSP_FLAAN
AccessioniPrimary (citable) accession number: O49850
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 1, 1998
Last modified: February 19, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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