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O49850

- GCSP_FLAAN

UniProt

O49850 - GCSP_FLAAN

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Protein

Glycine dehydrogenase (decarboxylating), mitochondrial

Gene

GDCSP

Organism
Flaveria anomala (Yellowtops)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.

Cofactori

Pyridoxal phosphate.

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating), mitochondrial (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:GDCSP
OrganismiFlaveria anomala (Yellowtops)
Taxonomic identifieri35877 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsAsteralesAsteraceaeAsteroideaeHeliantheae allianceTageteaeFlaveria

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 6363MitochondrionSequence AnalysisAdd
BLAST
Chaini64 – 1034971Glycine dehydrogenase (decarboxylating), mitochondrialPRO_0000010745Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei770 – 7701N6-(pyridoxal phosphate)lysineBy similarity

Interactioni

Subunit structurei

Homodimer (By similarity). The glycine cleavage system is composed of four proteins: P, T, L and H.By similarity

Structurei

3D structure databases

ProteinModelPortaliO49850.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.Curated

Keywords - Domaini

Transit peptide

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O49850-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MERARRLAML GRLVSQTKHN PSISSPALCS PSRYVSSLSP YVCGGTNVRS
60 70 80 90 100
DRNLNGFGSQ VRTISVEALK PSDTFPRRHN SATPEEQTKM AEFVGFSNLD
110 120 130 140 150
SLIDATVPKS IRLDSMKYSK FDEGLTESQM IAHMQDLASK NKIFKSFIGM
160 170 180 190 200
GYYNTSVPTV ILRNIMENPG WYTQYTPYQA EIAQGRLESL LNFQTMITDL
210 220 230 240 250
TGLPMSNASL LDEGTAAAEA MAMCNNIQKG KKKTFIIASN CHPQTIDICK
260 270 280 290 300
TRADGFDLKV VTSDLKDFDY SSGDVCGVLV QYPGTEGELL DYSEFIKNAH
310 320 330 340 350
ANGVKVVMAS DLLALTILKP PGELGADIVV GSAQRFGVPM GYGGPHAAFL
360 370 380 390 400
ATSQEYKRMM PGRIIGVSVD SSGKPALRMA MQTREQHIRR DKATSNICTA
410 420 430 440 450
QALLANMAAM YGVYHGPEGL KTIAKRVHGL AGTFAAGLKK LGTVQVQDLP
460 470 480 490 500
FFDTVKVTCA DSKAIAEEAC KHKMNLRIVD KNTITVAFDE TTTIEDVDTL
510 520 530 540 550
FKVFALGKPV PFTAASIAPE VQDAIPSGLV RETPYLTHPI FNMYHTEHEL
560 570 580 590 600
LRYISKLQSK DLSLCHSMIP LGSCTMKLNA TTEMMPVTWP AFADIHPFAP
610 620 630 640 650
TEQAQGYQEM FKNLGDLLCT ITGFDSFSLQ PNAGAAGEYA GLMVIRAYHM
660 670 680 690 700
ARGDHHRNVC IIPVSAHGTN PASAAMCGMK IITVGTDSKG NINIEELRKA
710 720 730 740 750
AEANKENLSA LMVTYPSTHG VYEEGIDEIC KIIHDNGGQV YMDGANMNAQ
760 770 780 790 800
VGLTSPGWIG ADVCHLNLHK TFCIPHGGGG PGMGPIGVKK HLAPYLPSHP
810 820 830 840 850
VVPTGGIPAP EESQPLGTIA AAPWGSALIL PISYTYIAMM GSQGITNASK
860 870 880 890 900
IAILNANYMA KRLENHYPIL FRGVNGTVAH EFIVDLRPLK TTAGIEPEDV
910 920 930 940 950
AKRLIDYGFH GPTMSWPVPG TLMIEPTESE SKAELDRFCD ALISIRQEIA
960 970 980 990 1000
EIEKGNVDFN NNVIKGAPHP PQLLMADKWT KPYSREYAAY PAPWLRAAKF
1010 1020 1030
WPTTCRVDNV YGDRNLICTL QPPQEYEEKA EATA
Length:1,034
Mass (Da):112,695
Last modified:June 1, 1998 - v1
Checksum:iC2F424C76EF104BA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z99762 Genomic DNA. Translation: CAB16911.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z99762 Genomic DNA. Translation: CAB16911.1 .

3D structure databases

ProteinModelPortali O49850.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The GDCSP gene encoding P-protein of the glycine cleavage system in the C3-C4 intermediate plant Flaveria anomala."
    Nan Q., Bauwe H.
    Plant Gene Register PGR98-004
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Leaf.

Entry informationi

Entry nameiGCSP_FLAAN
AccessioniPrimary (citable) accession number: O49850
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 1, 1998
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3