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Protein

Ras-related protein RABC2a

Gene

RABC2A

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Intracellular vesicle trafficking and protein transport.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi20 – 278GTPBy similarity
Nucleotide bindingi67 – 715GTPBy similarity
Nucleotide bindingi127 – 1304GTPBy similarity
Nucleotide bindingi157 – 1582GTPBy similarity

GO - Molecular functioni

  • GTP binding Source: UniProtKB-KW
  • GTP-dependent protein binding Source: TAIR
  • myosin XI tail binding Source: TAIR

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-6811436. COPI-independent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein RABC2a
Short name:
AtRABC2a
Alternative name(s):
Ras-related protein Rab18B
Short name:
AtRab18B
Gene namesi
Name:RABC2A
Synonyms:RAB18B
Ordered Locus Names:At5g03530
ORF Names:F12E4.310
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G03530.

Subcellular locationi

GO - Cellular componenti

  • peroxisome Source: TAIR
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 210209Ras-related protein RABC2aPRO_0000407358Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi208 – 2081S-geranylgeranyl cysteineBy similarity
Lipidationi209 – 2091S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Prenylation

Proteomic databases

PaxDbiO49841.
PRIDEiO49841.

PTM databases

iPTMnetiO49841.

Expressioni

Gene expression databases

GenevisibleiO49841. AT.

Interactioni

Subunit structurei

Interacts with XI-2/MYA2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
XI-2Q9LKB93EBI-2009559,EBI-2009528

GO - Molecular functioni

  • GTP-dependent protein binding Source: TAIR
  • myosin XI tail binding Source: TAIR

Protein-protein interaction databases

BioGridi17086. 1 interaction.
IntActiO49841. 1 interaction.
STRINGi3702.AT5G03530.1.

Structurei

3D structure databases

ProteinModelPortaliO49841.
SMRiO49841. Positions 13-183.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi41 – 499Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0080. Eukaryota.
ENOG410XPD0. LUCA.
HOGENOMiHOG000233968.
InParanoidiO49841.
KOiK07910.
OMAiGLFLECS.
PhylomeDBiO49841.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
PS00675. SIGMA54_INTERACT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O49841-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSSSGQSGY DLSFKILLIG DSGVGKSSLL VSFISSSVED LAPTIGVDFK
60 70 80 90 100
IKQLTVGGKR LKLTIWDTAG QERFRTLTSS YYRGAQGIIL VYDVTRRETF
110 120 130 140 150
TNLVDVWGKE IELYSTNQEC VRMLVGNKVD RESERGVSRE EGIALAKELN
160 170 180 190 200
CMFLECSART RQNVEQCFEE LALKIMEVPS LLEEGSSAVK RNILKQKPEH
210
QTNTQSGCCS
Length:210
Mass (Da):23,306
Last modified:June 1, 1998 - v1
Checksum:i551337D936809B5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89824 mRNA. Translation: BAA24074.1.
AL162751 Genomic DNA. Translation: CAB83314.1.
CP002688 Genomic DNA. Translation: AED90619.1.
AK119027 mRNA. Translation: BAC43603.1.
BT006101 mRNA. Translation: AAP04086.1.
PIRiT48379.
RefSeqiNP_568121.1. NM_120433.2.
UniGeneiAt.346.

Genome annotation databases

EnsemblPlantsiAT5G03530.1; AT5G03530.1; AT5G03530.
GeneIDi831810.
GrameneiAT5G03530.1; AT5G03530.1; AT5G03530.
KEGGiath:AT5G03530.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89824 mRNA. Translation: BAA24074.1.
AL162751 Genomic DNA. Translation: CAB83314.1.
CP002688 Genomic DNA. Translation: AED90619.1.
AK119027 mRNA. Translation: BAC43603.1.
BT006101 mRNA. Translation: AAP04086.1.
PIRiT48379.
RefSeqiNP_568121.1. NM_120433.2.
UniGeneiAt.346.

3D structure databases

ProteinModelPortaliO49841.
SMRiO49841. Positions 13-183.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi17086. 1 interaction.
IntActiO49841. 1 interaction.
STRINGi3702.AT5G03530.1.

PTM databases

iPTMnetiO49841.

Proteomic databases

PaxDbiO49841.
PRIDEiO49841.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G03530.1; AT5G03530.1; AT5G03530.
GeneIDi831810.
GrameneiAT5G03530.1; AT5G03530.1; AT5G03530.
KEGGiath:AT5G03530.

Organism-specific databases

TAIRiAT5G03530.

Phylogenomic databases

eggNOGiKOG0080. Eukaryota.
ENOG410XPD0. LUCA.
HOGENOMiHOG000233968.
InParanoidiO49841.
KOiK07910.
OMAiGLFLECS.
PhylomeDBiO49841.

Enzyme and pathway databases

ReactomeiR-ATH-6811436. COPI-independent Golgi-to-ER retrograde traffic.

Miscellaneous databases

PROiO49841.

Gene expression databases

GenevisibleiO49841. AT.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
PS00675. SIGMA54_INTERACT_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of a cDNA encoding a novel small GTP-binding protein from Arabidopsis thaliana."
    Mikami K., Ichimura K., Iuch S., Yamaguchi-Shinozaki K., Shinozaki K.
    Biochim. Biophys. Acta 1354:99-104(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
    Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
    , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
    Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  6. "Analysis of the small GTPase gene superfamily of Arabidopsis."
    Vernoud V., Horton A.C., Yang Z., Nielsen E.
    Plant Physiol. 131:1191-1208(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.
  7. "An isoform of Arabidopsis myosin XI interacts with small GTPases in its C-terminal tail region."
    Hashimoto K., Igarashi H., Mano S., Takenaka C., Shiina T., Yamaguchi M., Demura T., Nishimura M., Shimmen T., Yokota E.
    J. Exp. Bot. 59:3523-3531(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH XI-2/MYA2, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiRAC2A_ARATH
AccessioniPrimary (citable) accession number: O49841
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: June 1, 1998
Last modified: July 6, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.