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O49818 (LGUL_CICAR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lactoylglutathione lyase

EC=4.4.1.5
Alternative name(s):
Aldoketomutase
Glyoxalase I
Short name=Glx I
Ketone-aldehyde mutase
Methylglyoxalase
S-D-lactoylglutathione methylglyoxal lyase
OrganismCicer arietinum (Chickpea) (Garbanzo)
Taxonomic identifier3827 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeCicereaeCicer

Protein attributes

Sequence length186 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione By similarity.

Catalytic activity

(R)-S-lactoylglutathione = glutathione + methylglyoxal.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Pathway

Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.

Sequence similarities

Belongs to the glyoxalase I family.

Ontologies

Keywords
   LigandMetal-binding
Zinc
   Molecular functionLyase
Gene Ontology (GO)
   Molecular_functionlactoylglutathione lyase activity

Inferred from electronic annotation. Source: UniProtKB-EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 186186Lactoylglutathione lyase
PRO_0000168083

Regions

Region155 – 1562Substrate binding By similarity

Sites

Active site1711Proton donor/acceptor By similarity
Metal binding311Zinc By similarity
Metal binding971Zinc By similarity
Metal binding1251Zinc; via tele nitrogen By similarity
Metal binding1711Zinc By similarity
Binding site311Substrate By similarity
Binding site351Substrate By similarity
Binding site1011Substrate By similarity
Binding site1211Substrate By similarity
Binding site1251Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
O49818 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 96F5C729AC3C2E5E

FASTA18621,088
        10         20         30         40         50         60 
MAASESKESP ANNPGLHTTI DEATKGYFMQ QTMFRIKDPK VSLDFYSRVL GMSLLKRLDF 

        70         80         90        100        110        120 
PEMKFSLYFM GYEDTTEAPS NPVDRTVWTF AQKATIELTH NWGTESDPEF KGYHNGNSDP 

       130        140        150        160        170        180 
RGFGHIGITV DDTYKACERF QNLGVEFVKK PDDGKMKGIA FIKDPDGYWI ELFDRKTIGN 


VTEGNA 

« Hide

References

[1]"Isolation and characterization of a cDNA encoding a glyoxalase-I from Cicer arietinum L. Epicotyls upregulated by stress."
Romo S., Labrador E., Dopico B.
Plant Gene Register PGR98-074
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. Castellana.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ224520 mRNA. Translation: CAA12028.1.
RefSeqXP_004506056.1. XM_004505999.1.

3D structure databases

ProteinModelPortalO49818.
SMRO49818. Positions 21-181.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID101505694.
KEGGcam:101505694.

Phylogenomic databases

KOK01759.

Enzyme and pathway databases

UniPathwayUPA00619; UER00675.

Family and domain databases

InterProIPR004360. Glyas_Fos-R_dOase_dom.
IPR004361. Glyoxalase_1.
IPR018146. Glyoxalase_1_CS.
[Graphical view]
PfamPF00903. Glyoxalase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00068. glyox_I. 1 hit.
PROSITEPS00934. GLYOXALASE_I_1. 1 hit.
PS00935. GLYOXALASE_I_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLGUL_CICAR
AccessionPrimary (citable) accession number: O49818
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 1, 1998
Last modified: April 16, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways