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Protein

Transcription factor MYC4

Gene

MYC4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor involved in jasmonic acid (JA) gene regulation. With MYC2 and MYC3, controls additively subsets of JA-dependent responses. Can form complexes with all known glucosinolate-related MYBs to regulate glucosinolate biosynthesis. Binds to the G-box (5'-CACGTG-3') of promoters. Activates multiple TIFY/JAZ promoters.3 Publications

GO - Molecular functioni

  • bHLH transcription factor binding Source: TAIR
  • DNA binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: TAIR

GO - Biological processi

  • anthocyanin-containing compound biosynthetic process Source: TAIR
  • defense response Source: TAIR
  • positive regulation of transcription, DNA-templated Source: TAIR
  • regulation of transcription, DNA-templated Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor MYC4
Short name:
AtMYC4
Alternative name(s):
Basic helix-loop-helix protein 4
Short name:
AtbHLH4
Short name:
bHLH 4
Transcription factor EN 37
bHLH transcription factor bHLH004
Gene namesi
Name:MYC4
Synonyms:BHLH4, EN37
Ordered Locus Names:At4g17880
ORF Names:T6K21.60
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G17880.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Minor effect on jasmonic acid response and no effect on glucosinolate biosynthesis. Myc2 and myc4 double mutant has an increased insensitivity to jasmonic acid. Myc2, myc3 and myc4 triple mutant has no jasmonate-related defense response, is devoid of glucosinolates and is extremely susceptible to generalist herbivores.3 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 589589Transcription factor MYC4PRO_0000358725Add
BLAST

Proteomic databases

PaxDbiO49687.
PRIDEiO49687.

Expressioni

Tissue specificityi

Expressed constitutively at low levels. Preferentially expressed in vascular tissues.2 Publications

Inductioni

By UV treatment. Not induced by jasmonic acid.2 Publications

Gene expression databases

GenevisibleiO49687. AT.

Interactioni

Subunit structurei

Homo- and heterodimer. Interacts with MYB28, MYB29, MYB34, MYB51, MYB76, MYB122, MYC3, AFPH2/NINJA and the JAZ repressors TIFY10A/JAZ1, TIFY10B/JAZ2, TIFY6B/JAZ3, TIFY6A/JAZ4, TIFY11A/JAZ5, TIFY11B/JAZ6, TIFY5B/JAZ7, TIFY5A/JAZ8, TIFY7/JAZ9, TIFY9/JAZ10, TIFY3A/JAZ11 and TIFY3B/JAZ12.3 Publications

GO - Molecular functioni

  • bHLH transcription factor binding Source: TAIR

Protein-protein interaction databases

BioGridi12804. 26 interactions.
DIPiDIP-61779N.
STRINGi3702.AT4G17880.1.

Structurei

3D structure databases

ProteinModelPortaliO49687.
SMRiO49687. Positions 20-252, 415-463.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini412 – 46150bHLHPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni99 – 15052JAZ-interaction domainAdd
BLAST

Domaini

The JAZ-interaction domain (JID) (99-150) is sufficient for interaction with MYB proteins and most of the TIFY/JAZ proteins.1 Publication

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IGFU. Eukaryota.
ENOG410YCJJ. LUCA.
HOGENOMiHOG000238207.
InParanoidiO49687.
OrthoDBiEOG093607T9.
PhylomeDBiO49687.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR025610. MYC/MYB_N.
[Graphical view]
PfamiPF14215. bHLH-MYC_N. 1 hit.
PF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O49687-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPTNVQVTD YHLNQSKTDT TNLWSTDDDA SVMEAFIGGG SDHSSLFPPL
60 70 80 90 100
PPPPLPQVNE DNLQQRLQAL IEGANENWTY AVFWQSSHGF AGEDNNNNNT
110 120 130 140 150
VLLGWGDGYY KGEEEKSRKK KSNPASAAEQ EHRKRVIREL NSLISGGVGG
160 170 180 190 200
GDEAGDEEVT DTEWFFLVSM TQSFVKGTGL PGQAFSNSDT IWLSGSNALA
210 220 230 240 250
GSSCERARQG QIYGLQTMVC VATENGVVEL GSSEIIHQSS DLVDKVDTFF
260 270 280 290 300
NFNNGGGEFG SWAFNLNPDQ GENDPGLWIS EPNGVDSGLV AAPVMNNGGN
310 320 330 340 350
DSTSNSDSQP ISKLCNGSSV ENPNPKVLKS CEMVNFKNGI ENGQEEDSSN
360 370 380 390 400
KKRSPVSNNE EGMLSFTSVL PCDSNHSDLE ASVAKEAESN RVVVEPEKKP
410 420 430 440 450
RKRGRKPANG REEPLNHVEA ERQRREKLNQ RFYSLRAVVP NVSKMDKASL
460 470 480 490 500
LGDAISYISE LKSKLQKAES DKEELQKQID VMNKEAGNAK SSVKDRKCLN
510 520 530 540 550
QESSVLIEME VDVKIIGWDA MIRIQCSKRN HPGAKFMEAL KELDLEVNHA
560 570 580
SLSVVNDLMI QQATVKMGNQ FFTQDQLKVA LTEKVGECP
Length:589
Mass (Da):64,589
Last modified:June 1, 1998 - v1
Checksum:iC962E83290DF9CCC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21S → A in AAL55711 (PubMed:12679534).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251689 mRNA. Translation: AAL55711.1.
AL021889 Genomic DNA. Translation: CAA17131.1.
AL161547 Genomic DNA. Translation: CAB78790.1.
CP002687 Genomic DNA. Translation: AEE83960.1.
AK221507 mRNA. Translation: BAD94748.1.
PIRiT05074.
RefSeqiNP_193522.1. NM_117897.3.
UniGeneiAt.28316.

Genome annotation databases

EnsemblPlantsiAT4G17880.1; AT4G17880.1; AT4G17880.
GeneIDi827511.
GrameneiAT4G17880.1; AT4G17880.1; AT4G17880.
KEGGiath:AT4G17880.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251689 mRNA. Translation: AAL55711.1.
AL021889 Genomic DNA. Translation: CAA17131.1.
AL161547 Genomic DNA. Translation: CAB78790.1.
CP002687 Genomic DNA. Translation: AEE83960.1.
AK221507 mRNA. Translation: BAD94748.1.
PIRiT05074.
RefSeqiNP_193522.1. NM_117897.3.
UniGeneiAt.28316.

3D structure databases

ProteinModelPortaliO49687.
SMRiO49687. Positions 20-252, 415-463.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi12804. 26 interactions.
DIPiDIP-61779N.
STRINGi3702.AT4G17880.1.

Proteomic databases

PaxDbiO49687.
PRIDEiO49687.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G17880.1; AT4G17880.1; AT4G17880.
GeneIDi827511.
GrameneiAT4G17880.1; AT4G17880.1; AT4G17880.
KEGGiath:AT4G17880.

Organism-specific databases

TAIRiAT4G17880.

Phylogenomic databases

eggNOGiENOG410IGFU. Eukaryota.
ENOG410YCJJ. LUCA.
HOGENOMiHOG000238207.
InParanoidiO49687.
OrthoDBiEOG093607T9.
PhylomeDBiO49687.

Miscellaneous databases

PROiO49687.

Gene expression databases

GenevisibleiO49687. AT.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR025610. MYC/MYB_N.
[Graphical view]
PfamiPF14215. bHLH-MYC_N. 1 hit.
PF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYC4_ARATH
AccessioniPrimary (citable) accession number: O49687
Secondary accession number(s): Q8W2F6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: June 1, 1998
Last modified: September 7, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.