ID   O49652_ARATH            Unreviewed;       526 AA.
AC   O49652;
DT   01-JUN-1998, integrated into UniProtKB/TrEMBL.
DT   01-JUN-1998, sequence version 1.
DT   27-MAR-2024, entry version 177.
DE   SubName: Full=Cytochrome P450 - like protein {ECO:0000313|EMBL:CAA16556.1};
DE   SubName: Full=Cytochrome P450, family 706, subfamily A, polypeptide 2 {ECO:0000313|EMBL:AEE84642.1};
DE   SubName: Full=Cytochrome P450-like protein {ECO:0000313|EMBL:BAD43506.1};
GN   Name=CYP706A2 {ECO:0000313|EMBL:AEE84642.1,
GN   ECO:0000313|TAIR:AT4G22710};
GN   Synonyms=cytochrome P450 {ECO:0000313|EMBL:AEE84642.1}, family 706
GN   {ECO:0000313|EMBL:AEE84642.1}, polypeptide 2
GN   {ECO:0000313|EMBL:AEE84642.1}, subfamily A
GN   {ECO:0000313|EMBL:AEE84642.1};
GN   OrderedLocusNames=At4g22710 {ECO:0000313|Araport:AT4G22710,
GN   ECO:0000313|EMBL:AEE84642.1};
GN   ORFNames=T12H17.100 {ECO:0000313|EMBL:CAA16556.1}, T12H17_100
GN   {ECO:0000313|EMBL:AEE84642.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702 {ECO:0000313|EMBL:CAA16556.1};
RN   [1] {ECO:0000313|EMBL:CAA16556.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Bevan M., Hilbert H., Braun M., Holzer E., Brandt A., Duesterhoeft A.,
RA   Bancroft I., Mewes H.W., Mayer K., Schueller C.;
RL   Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CAA16556.1}
RP   NUCLEOTIDE SEQUENCE.
RA   EU Arabidopsis sequencing project;
RL   Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:AEE84642.1, ECO:0000313|Proteomes:UP000006548}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX   PubMed=10617198; DOI=10.1038/47134;
RG   EU;
RG   CSHL and WU Arabidopsis Sequencing Project;
RA   Mayer K., Schuller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA   Dusterhoft A., Stiekema W., Entian K.D., Terryn N., Harris B., Ansorge W.,
RA   Brandt P., Grivell L., Rieger M., Weichselgartner M., de Simone V.,
RA   Obermaier B., Mache R., Muller M., Kreis M., Delseny M., Puigdomenech P.,
RA   Watson M., Schmidtheini T., Reichert B., Portatelle D., Perez-Alonso M.,
RA   Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H.,
RA   Ridley P., Langham S.A., McCullagh B., Bilham L., Robben J.,
RA   Van der Schueren J., Grymonprez B., Chuang Y.J., Vandenbussche F.,
RA   Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E.,
RA   Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E.,
RA   Brandt A., Peters S., van Staveren M., Dirske W., Mooijman P.,
RA   Klein Lankhorst R., Rose M., Hauf J., Kotter P., Berneiser S., Hempel S.,
RA   Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA   Gielen J., Villarroel R., De Clercq R., Van Montagu M., Rogers J.,
RA   Cronin A., Quail M., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M.,
RA   Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M.,
RA   Benes V., Rechmann S., Borkova D., Blocker H., Scharfe M., Grimm M.,
RA   Lohnert T.H., Dose S., de Haan M., Maarse A., Schafer M., Muller-Auer S.,
RA   Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A.,
RA   Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O.,
RA   Quigley F., Clabauld G., Mundlein A., Felber R., Schnabl S., Hiller R.,
RA   Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C.,
RA   Montfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA   Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA   Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA   Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA   Mewes H.W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA   de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA   Huang E., Spiegel L., Sehkon M., Murray J., Sheet P., Cordes M.,
RA   Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA   Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA   Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA   Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L., Nelson J.,
RA   Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J.,
RA   Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA   Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA   Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA   O'Shaughnessy A., Rodriguez M., Hoffmann J., Till S., Granat S., Shohdy N.,
RA   Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.,
RA   Martienssen R., McCombie W.R.;
RT   "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL   Nature 402:769-777(1999).
RN   [4] {ECO:0000313|EMBL:CAB79226.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Hilbert H., Braun M., Holzer E., Brandt A., Duesterhoeft A., Mewes H.W.,
RA   Lemcke K., Mayer K.F.X.;
RL   Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|EMBL:BAD43506.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA   Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA   Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA   Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA   Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|EMBL:AEE84642.1}
RP   NUCLEOTIDE SEQUENCE.
RG   TAIR;
RA   Swarbreck D., Lamesch P., Wilks C., Huala E.;
RL   Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|EMBL:AEE84642.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Krishnakumar V., Cheng C.-Y., Chan A.P., Schobel S., Kim M., Ferlanti E.S.,
RA   Belyaeva I., Rosen B.D., Micklem G., Miller J.R., Vaughn M., Town C.D.;
RL   Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|Proteomes:UP000006548}
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC       {ECO:0000256|RuleBase:RU000461}.
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DR   EMBL; CP002687; AEE84642.1; -; Genomic_DNA.
DR   EMBL; AK175743; BAD43506.1; -; mRNA.
DR   EMBL; AK175975; BAD43738.1; -; mRNA.
DR   EMBL; AL021635; CAA16556.1; -; Genomic_DNA.
DR   EMBL; AL161557; CAB79226.1; -; Genomic_DNA.
DR   PIR; T04566; T04566.
DR   RefSeq; NP_194002.1; NM_118397.4.
DR   AlphaFoldDB; O49652; -.
DR   SMR; O49652; -.
DR   IntAct; O49652; 1.
DR   MINT; O49652; -.
DR   STRING; 3702.O49652; -.
DR   PaxDb; 3702-AT4G22710-1; -.
DR   ProteomicsDB; 191614; -.
DR   EnsemblPlants; AT4G22710.1; AT4G22710.1; AT4G22710.
DR   GeneID; 828367; -.
DR   Gramene; AT4G22710.1; AT4G22710.1; AT4G22710.
DR   KEGG; ath:AT4G22710; -.
DR   Araport; AT4G22710; -.
DR   TAIR; AT4G22710; CYP706A2.
DR   eggNOG; KOG0156; Eukaryota.
DR   HOGENOM; CLU_001570_4_0_1; -.
DR   OMA; CKEVAIM; -.
DR   OrthoDB; 2900138at2759; -.
DR   BioCyc; ARA:AT4G22710-MONOMER; -.
DR   Proteomes; UP000006548; Chromosome 4.
DR   ExpressionAtlas; O49652; baseline and differential.
DR   GO; GO:0005794; C:Golgi apparatus; HDA:TAIR.
DR   GO; GO:0005886; C:plasma membrane; HDA:TAIR.
DR   GO; GO:0009506; C:plasmodesma; HDA:TAIR.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   CDD; cd11073; CYP76-like; 1.
DR   Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   PANTHER; PTHR47951:SF1; CYTOCHROME P450 - LIKE PROTEIN-RELATED; 1.
DR   PANTHER; PTHR47951; OS08G0547900 PROTEIN; 1.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; Cytochrome P450; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   1: Evidence at protein level;
KW   Heme {ECO:0000256|RuleBase:RU000461}; Iron {ECO:0000256|RuleBase:RU000461};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|RuleBase:RU000461};
KW   Monooxygenase {ECO:0000256|RuleBase:RU000461};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000461};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:O49652,
KW   ECO:0007829|ProteomicsDB:O49652};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006548};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        22..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   526 AA;  59426 MW;  95E0783D45E91D9E CRC64;
     MGTASSKSNI NLSQVLNTEE PYSSVMLAVA ALLAVVCYLW IQGKSKSKKE PPLPPGPWPL
     PIVGNLPFLN SDVLHTQFQA LTLKYGPLMK IHLGSKLAIV VSSPDMAREV LKTHDITFAN
     HDLPEVGKIN TYGGEDILWS PYGTHWRRLR KLCVMKMFTT PSLEASYSTR REETRQTIVH
     MSEMAREGSP VNLGEQIFLS IFNVVTRMMW GATVEGDERT SLGNELKTLI SDISDIEGIQ
     NYSDFFPLFS RFDFQGLVKQ MKGHVKKLDL LFDRVMESHV KMVGKKSEEE EDFLQYLLRV
     KDDDEKAPLS MTHVKSLLMD MVLGGVDTSV NASEFAMAEI VSRPEVLNKI RLELDQVVGK
     DNIVEESHLP KLPYLQAVMK ETLRLHPTLP LLVPHRNSET SVVAGYTVPK DSKIFINVWA
     IHRDPKNWDE PNEFKPERFL ENSLDFNGGD FKYLPFGSGR RICAAINMAE RLVLFNIASL
     LHSFDWKAPQ GQKFEVEEKF GLVLKLKSPL VAIPVPRLSD PKLYTA
//