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Protein

Peptidyl-prolyl cis-trans isomerase CYP21-1

Gene

CYP21-1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone, Isomerase, Rotamase

Keywords - Ligandi

Cyclosporin

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase CYP21-1 (EC:5.2.1.8)
Short name:
PPIase CYP21-1
Alternative name(s):
Cyclophilin of 21 kDa 1
Cyclophilin-21-1
Gene namesi
Name:CYP21-1
Ordered Locus Names:At4g34960
ORF Names:M4E13.20
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G34960.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum Source: UniProtKB-SubCell
  • endosome Source: TAIR
  • Golgi apparatus Source: TAIR
  • trans-Golgi network Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000042993428 – 224Peptidyl-prolyl cis-trans isomerase CYP21-1Add BLAST197

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi158N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO49605.

PTM databases

SwissPalmiO49605.

Expressioni

Tissue specificityi

Ubiquitous.2 Publications

Gene expression databases

GenevisibleiO49605. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT4G34960.1.

Structurei

3D structure databases

ProteinModelPortaliO49605.
SMRiO49605.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 214PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST165

Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.Curated
Contains 1 PPIase cyclophilin-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0865. Eukaryota.
COG0652. LUCA.
HOGENOMiHOG000065981.
InParanoidiO49605.
OMAiFLLQPRC.
OrthoDBiEOG09360LF2.
PhylomeDBiO49605.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O49605-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRREISFLLQ PRCLLLLVAL TIFLVFALFN TGKDEEKQVI EDHEITNRVF
60 70 80 90 100
LDVDIDGQRL GRIVIGLYGT VVPKTVENFR ALCTGEKGKT SSGKPLHYKG
110 120 130 140 150
TPFHRIISGF VIQGGDIIHG DGKSSDSIYG GTFPDENFKI QHSHAGMVAM
160 170 180 190 200
ANTGPDSNGS QFFITTVKAS WLEGEHVVLG KVIQGMDNVF AIEGGAGTYS
210 220
GKPRKKVVIA DSGEIPKDKW DEER
Length:224
Mass (Da):24,594
Last modified:June 1, 1998 - v1
Checksum:i1E4682ADE86D5E64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY568518 mRNA. Translation: AAS75301.1.
AL022023 Genomic DNA. Translation: CAA17761.1.
AL161586 Genomic DNA. Translation: CAB80213.1.
CP002687 Genomic DNA. Translation: AEE86441.1.
BT004972 mRNA. Translation: AAO50505.1.
AK117671 mRNA. Translation: BAC42324.1.
PIRiT05766.
RefSeqiNP_195222.1. NM_119662.4.
UniGeneiAt.31457.

Genome annotation databases

EnsemblPlantsiAT4G34960.1; AT4G34960.1; AT4G34960.
GeneIDi829648.
GrameneiAT4G34960.1; AT4G34960.1; AT4G34960.
KEGGiath:AT4G34960.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY568518 mRNA. Translation: AAS75301.1.
AL022023 Genomic DNA. Translation: CAA17761.1.
AL161586 Genomic DNA. Translation: CAB80213.1.
CP002687 Genomic DNA. Translation: AEE86441.1.
BT004972 mRNA. Translation: AAO50505.1.
AK117671 mRNA. Translation: BAC42324.1.
PIRiT05766.
RefSeqiNP_195222.1. NM_119662.4.
UniGeneiAt.31457.

3D structure databases

ProteinModelPortaliO49605.
SMRiO49605.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT4G34960.1.

PTM databases

SwissPalmiO49605.

Proteomic databases

PaxDbiO49605.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G34960.1; AT4G34960.1; AT4G34960.
GeneIDi829648.
GrameneiAT4G34960.1; AT4G34960.1; AT4G34960.
KEGGiath:AT4G34960.

Organism-specific databases

TAIRiAT4G34960.

Phylogenomic databases

eggNOGiKOG0865. Eukaryota.
COG0652. LUCA.
HOGENOMiHOG000065981.
InParanoidiO49605.
OMAiFLLQPRC.
OrthoDBiEOG09360LF2.
PhylomeDBiO49605.

Miscellaneous databases

PROiO49605.

Gene expression databases

GenevisibleiO49605. AT.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCP21A_ARATH
AccessioniPrimary (citable) accession number: O49605
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 9, 2014
Last sequence update: June 1, 1998
Last modified: November 30, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.