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Protein

Peptidyl-prolyl cis-trans isomerase CYP21-1

Gene

CYP21-1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone, Isomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase CYP21-1 (EC:5.2.1.8)
Short name:
PPIase CYP21-1
Alternative name(s):
Cyclophilin of 21 kDa 1
Cyclophilin-21-1
Gene namesi
Name:CYP21-1
Ordered Locus Names:At4g34960
ORF Names:M4E13.20
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G34960
TAIRilocus:2131546 AT4G34960

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000042993428 – 224Peptidyl-prolyl cis-trans isomerase CYP21-1Add BLAST197

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi158N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO49605
PRIDEiO49605

PTM databases

SwissPalmiO49605

Expressioni

Tissue specificityi

Ubiquitous.2 Publications

Gene expression databases

ExpressionAtlasiO49605 baseline and differential
GenevisibleiO49605 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT4G34960.1

Structurei

3D structure databases

ProteinModelPortaliO49605
SMRiO49605
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 214PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST165

Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0865 Eukaryota
COG0652 LUCA
HOGENOMiHOG000065981
InParanoidiO49605
OMAiDRPLTNC
OrthoDBiEOG09360LF2
PhylomeDBiO49605

Family and domain databases

Gene3Di2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
PANTHERiPTHR11071 PTHR11071, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PIRSFiPIRSF001467 Peptidylpro_ismrse, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SUPFAMiSSF50891 SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O49605-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRREISFLLQ PRCLLLLVAL TIFLVFALFN TGKDEEKQVI EDHEITNRVF
60 70 80 90 100
LDVDIDGQRL GRIVIGLYGT VVPKTVENFR ALCTGEKGKT SSGKPLHYKG
110 120 130 140 150
TPFHRIISGF VIQGGDIIHG DGKSSDSIYG GTFPDENFKI QHSHAGMVAM
160 170 180 190 200
ANTGPDSNGS QFFITTVKAS WLEGEHVVLG KVIQGMDNVF AIEGGAGTYS
210 220
GKPRKKVVIA DSGEIPKDKW DEER
Length:224
Mass (Da):24,594
Last modified:June 1, 1998 - v1
Checksum:i1E4682ADE86D5E64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY568518 mRNA Translation: AAS75301.1
AL022023 Genomic DNA Translation: CAA17761.1
AL161586 Genomic DNA Translation: CAB80213.1
CP002687 Genomic DNA Translation: AEE86441.1
BT004972 mRNA Translation: AAO50505.1
AK117671 mRNA Translation: BAC42324.1
PIRiT05766
RefSeqiNP_195222.1, NM_119662.4
UniGeneiAt.31457

Genome annotation databases

EnsemblPlantsiAT4G34960.1; AT4G34960.1; AT4G34960
GeneIDi829648
GrameneiAT4G34960.1; AT4G34960.1; AT4G34960
KEGGiath:AT4G34960

Similar proteinsi

Entry informationi

Entry nameiCP21A_ARATH
AccessioniPrimary (citable) accession number: O49605
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 9, 2014
Last sequence update: June 1, 1998
Last modified: May 23, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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