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Protein

High mobility group B protein 1

Gene

HMGB1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds preferentially double-stranded DNA. Modulates general plant growth and stress tolerance. Confers sensitivity to salt and genotoxic (methyl methanesulfonate, MMS) stresses.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi53 – 122HMG boxPROSITE-ProRule annotationAdd BLAST70

GO - Molecular functioni

  • chromatin binding Source: TAIR
  • DNA binding Source: TAIR
  • DNA binding transcription factor activity Source: TAIR
  • structural constituent of chromatin Source: TAIR

GO - Biological processi

  • chromatin assembly or disassembly Source: TAIR

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
High mobility group B protein 1
Alternative name(s):
High mobility group protein A
Short name:
AtHMGalpha
Short name:
HMG alpha
Nucleosome/chromatin assembly factor group D 01
Short name:
Nucleosome/chromatin assembly factor group D 1
Gene namesi
Name:HMGB1
Synonyms:HMGA, HMGALPHA, NFD01, NFD1, ORF13
Ordered Locus Names:At3g51880
ORF Names:ATEM1.13
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G51880
TAIRilocus:2074368 AT3G51880

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Slightly delayed and reduced germination rate. Reduced root length. Enhanced sensitivity to methyl methanesulfonate (MMS).1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003999271 – 178High mobility group B protein 1Add BLAST178

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei137PhosphoserineCombined sources1
Modified residuei146PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO49595
PRIDEiO49595

PTM databases

iPTMnetiO49595

Expressioni

Tissue specificityi

Expressed in cotyledons, roots, stems, leaves and flowers (excluding pedicels).3 Publications

Inductioni

Down-regulated by salt stress.1 Publication

Gene expression databases

ExpressionAtlasiO49595 baseline and differential
GenevisibleiO49595 AT

Interactioni

Protein-protein interaction databases

IntActiO49595, 4 interactors
STRINGi3702.AT3G51880.2

Structurei

3D structure databases

ProteinModelPortaliO49595
SMRiO49595
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi99 – 177Glu-richAdd BLAST79

Sequence similaritiesi

Belongs to the HMGB family.Curated

Phylogenomic databases

eggNOGiKOG0381 Eukaryota
COG5648 LUCA
HOGENOMiHOG000197860
InParanoidiO49595
KOiK10802
OMAiEDFRTTF
PhylomeDBiO49595

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O49595-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKTAKGKDKV KTTKEALKPV DDRKVGKRKA PAEKPTKRET RKEKKAKKDP
60 70 80 90 100
NKPKRAPSAF FVFLEDFRVT FKKENPNVKA VSAVGKAGGQ KWKSMSQAEK
110 120 130 140 150
APYEEKAAKR KAEYEKQMDA YNKNLEEGSD ESEKSRSEIN DEDEASGEEE
160 170
LLEKEAAGDD EEEEEEEDDD DDDDEEED
Length:178
Mass (Da):20,265
Last modified:June 1, 1998 - v1
Checksum:i2C1130786210828B
GO
Isoform 2 (identifier: O49595-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     148-148: E → EVTIPLSN

Note: No experimental confirmation available.
Show »
Length:185
Mass (Da):20,990
Checksum:i8EF5428E8386E868
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_039939148E → EVTIPLSN in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14071 mRNA Translation: CAA74400.1
AF049236 Genomic DNA Translation: AAC14415.1
CP002686 Genomic DNA Translation: AEE78855.1
CP002686 Genomic DNA Translation: AEE78856.1
CP002686 Genomic DNA Translation: AEE78857.1
CP002686 Genomic DNA Translation: ANM65542.1
AY056373 mRNA Translation: AAL08229.1
AY113172 mRNA Translation: AAM47475.1
AK316819 mRNA Translation: BAH19531.1
PIRiT51159
RefSeqiNP_001078269.1, NM_001084800.2 [O49595-1]
NP_001327501.1, NM_001339538.1 [O49595-1]
NP_190756.1, NM_115047.3 [O49595-1]
NP_974413.1, NM_202684.3 [O49595-2]
UniGeneiAt.27677
At.480

Genome annotation databases

EnsemblPlantsiAT3G51880.1; AT3G51880.1; AT3G51880 [O49595-1]
AT3G51880.2; AT3G51880.2; AT3G51880 [O49595-2]
AT3G51880.3; AT3G51880.3; AT3G51880 [O49595-1]
AT3G51880.5; AT3G51880.5; AT3G51880 [O49595-1]
GeneIDi824351
GrameneiAT3G51880.1; AT3G51880.1; AT3G51880 [O49595-1]
AT3G51880.2; AT3G51880.2; AT3G51880 [O49595-2]
AT3G51880.3; AT3G51880.3; AT3G51880 [O49595-1]
AT3G51880.5; AT3G51880.5; AT3G51880 [O49595-1]
KEGGiath:AT3G51880

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiHMGB1_ARATH
AccessioniPrimary (citable) accession number: O49595
Secondary accession number(s): Q3EAL6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: June 1, 1998
Last modified: May 23, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health