Reviewed,
UniProtKB/Swiss-Prot O49484 (ASK11_ARATH)
Last modified
June 16, 2009.
Version 55.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: SKP1-like protein 11 Short name=AtSK11 | ||||||
| Gene names |
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| Organism | Arabidopsis thaliana (Mouse-ear cress) [Complete proteome] | ||||||
| Taxonomic identifier | 3702 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis |
Protein attributes
| Sequence length | 152 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends of the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1 By similarity. Plays a role during early flowers reproductive development. |
| Pathway | |
| Subunit structure | Part of a SCF (SKP1-cullin-F-box) protein ligase complex By similarity. Interacts with ADO3/FKF1, COI1/FBL2, EBF1/FBL6, PP2A13, PP2B10, UFO, SKIP2, SKIP15, SKIP16, SKIP32, At1g55000, At1g67340, At1g78100, At3g04660, At3g16740, At3g61590, At4g38940 and At5g49610. |
| Subcellular location | Nucleus By similarity. |
| Tissue specificity | Expressed in young seedlings, cotyledons, roots, leaves, floral stems, inflorescences, pollen, and siliques, with a slightly higher level in inflorescence than in other tissues. |
| Developmental stage | Expressed in the inflorescence meristem (IM) and young buds, particularly in stamen. Also detected in pollen grains. |
| Sequence similarities | Belongs to the SKP1 family. |
| Sequence caution | The sequence ABK28664.1 differs from that shown. Reason: Erroneous termination at position 153. Translated as stop. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Ubl conjugation pathway |
| Cellular component | Nucleus |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro |
| Molecular function | ligase activity Inferred from electronic annotation. Source: UniProtKB-KW protein binding Ref.3 Ref.5Inferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| ADO1 | Q94BT6 | 2 | EBI-401185,EBI-300691 | |
| ADO3 | Q9C9W9 | 2 | EBI-401185,EBI-401228 | |
| EBF1 | Q9SKK0 | 2 | EBI-401185,EBI-401198 | |
| FBX3 | O49279 | 2 | EBI-401185,EBI-591174 | |
| PP2A13 | Q9LEX0 | 2 | EBI-401185,EBI-604261 | |
| UFO | Q39090 | 2 | EBI-401185,EBI-590758 |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana." Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B. McCombie W.R.Nature 402:769-777(1999) [PubMed: 10617198] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia. |
| [2] | "Simultaneous high-throughput recombinational cloning of open reading frames in closed and open configurations." Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P. Plant Biotechnol. J. 4:317-324(2006) [PubMed: 17147637] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia. |
| [3] | "The F-box subunit of the SCF E3 complex is encoded by a diverse superfamily of genes in Arabidopsis." Gagne J.M., Downes B.P., Shiu S.-H., Durski A.M., Vierstra R.D. Proc. Natl. Acad. Sci. U.S.A. 99:11519-11524(2002) [PubMed: 12169662] [Abstract] Cited for: INTERACTION WITH UFO; PP2A13; AT1G67340; AT4G38940; SKIP15; AT3G16740; AT3G04660; AT1G78100; AT1G55000; SKIP16; SKIP2; SKIP32 AND EBF1. |
| [4] | "Members of the Arabidopsis-SKP1-like gene family exhibit a variety of expression patterns and may play diverse roles in Arabidopsis." Zhao D., Ni W., Feng B., Han T., Petrasek M.G., Ma H. Plant Physiol. 133:203-217(2003) [PubMed: 12970487] [Abstract] Cited for: FUNCTION, GENE FAMILY, NOMENCLATURE, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. |
| [5] | "Expression and interaction analysis of Arabidopsis Skp1-related genes." Takahashi N., Kuroda H., Kuromori T., Hirayama T., Seki M., Shinozaki K., Shimada H., Matsui M. Plant Cell Physiol. 45:83-91(2004) [PubMed: 14749489] [Abstract] Cited for: TISSUE SPECIFICITY, INTERACTION WITH EBF1/FBL6; COI1/FBL2; ADO3/FKF1; PP2B10; AT3G61590 AND AT5G49610. |
Web resources
| PlantsUBQ A functional genomics database for the ubiquitin/26S proteasome proteolytic pathway in plants |
Cross-references
Sequence databases | |
|---|---|
| AL021961 Genomic DNA. Translation: CAA17551.1. AL161585 Genomic DNA. Translation: CAB80138.1. DQ446893 mRNA. Translation: ABE66110.1. DQ653243 mRNA. Translation: ABK28664.1. | |
| IPI | IPI00541308. |
| PIR | T05415. |
| RefSeq | NP_567959.1. |
| UniGene | At.54598 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1FQV based on UniProtKB P34991. |
| SMR | O49484. Positions 6-152. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | O49484. 34 interactions. |
Genome annotation databases | |
| GeneID | 829569. |
| KEGG | ath:AT4G34210. |
| NMPDR | fig|3702.1.peg.21481. |
Organism-specific databases | |
| TAIR | At4g34210. |
Phylogenomic databases | |
| OMA | O49484. IRRAFNI. |
Gene expression databases | |
| ArrayExpress | O49484. |
Family and domain databases | |
| InterPro | IPR011333. BTB/POZ_fold. IPR016897. E3_ubiquit_lig_SCF_Skp. IPR001232. Skp1_comp. IPR016072. Skp1_comp_dimer. IPR016073. Skp1_comp_POZ. [Graphical view] |
| Gene3D | G3DSA:3.30.710.10. BTB/POZ_fold. 1 hit. |
| PANTHER | PTHR11165. Skp1. 1 hit. |
| Pfam | PF01466. Skp1. 1 hit. PF03931. Skp1_POZ. 1 hit. [Graphical view] |
| PIRSF | PIRSF028729. E3_ubiquit_lig_SCF_Skp. 1 hit. |
| SMART | SM00512. Skp1. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ASK11_ARATH | ||||||||
| Accession | Primary (citable) accession number: O49484 Secondary accession number(s): A0MFB7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | PPAP (Plant Proteome Annotation Project) | ||||||||
Relevant documents
| Arabidopsis thaliana Arabidopsis thaliana: entries and gene names |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


