O49484 (ASK11_ARATH) Reviewed, UniProtKB/Swiss-Prot
Last modified
November 16, 2011.
Version 74.
History...
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: SKP1-like protein 11 Short name=AtSK11 | ||||||
| Gene names |
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| Organism | Arabidopsis thaliana (Mouse-ear cress) | ||||||
| Taxonomic identifier | 3702 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Protein attributes
| Sequence length | 152 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends of the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1 By similarity. Plays a role during early flowers reproductive development. Ref.5 |
| Pathway | |
| Subunit structure | Part of a SCF (SKP1-cullin-F-box) protein ligase complex By similarity. Interacts with ADO3/FKF1, COI1/FBL2, EBF1/FBL6, PP2A13, PP2B10, UFO, SKIP2, SKIP15, SKIP16, SKIP32, CPR30, At1g55000, At1g67340, At1g78100, At3g04660, At3g16740, At3g61590, At4g38940 and At5g49610. Ref.4 Ref.6 Ref.7 |
| Subcellular location | Nucleus By similarity. |
| Tissue specificity | Expressed in young seedlings, cotyledons, roots, leaves, floral stems, inflorescences, pollen, and siliques, with a slightly higher level in inflorescence than in other tissues. Ref.5 Ref.6 |
| Developmental stage | Expressed in the inflorescence meristem (IM) and young buds, particularly in stamen. Also detected in pollen grains. Ref.5 |
| Sequence similarities | Belongs to the SKP1 family. |
| Sequence caution | The sequence ABK28664.1 differs from that shown. Reason: Erroneous termination at position 153. Translated as stop. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Ubl conjugation pathway |
| Cellular component | Nucleus |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro |
| Cellular component | nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | protein binding Inferred from physical interaction Ref.7. Source: UniProtKB |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| ADO1 | Q94BT6 | 3 | EBI-401185,EBI-300691 | |
| EBF1 | Q9SKK0 | 3 | EBI-401185,EBI-401198 | |
| EID1 | Q8LEA8 | 3 | EBI-401185,EBI-687388 | |
| SKIP15 | O49279 | 3 | EBI-401185,EBI-591174 | |
| UFO | Q39090 | 3 | EBI-401185,EBI-590758 |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana." Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B. McCombie W.R.Nature 402:769-777(1999) [PubMed: 10617198] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia. |
| [2] | The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia. |
| [3] | "Simultaneous high-throughput recombinational cloning of open reading frames in closed and open configurations." Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P. Plant Biotechnol. J. 4:317-324(2006) [PubMed: 17147637] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia. |
| [4] | "The F-box subunit of the SCF E3 complex is encoded by a diverse superfamily of genes in Arabidopsis." Gagne J.M., Downes B.P., Shiu S.-H., Durski A.M., Vierstra R.D. Proc. Natl. Acad. Sci. U.S.A. 99:11519-11524(2002) [PubMed: 12169662] [Abstract] Cited for: INTERACTION WITH UFO; PP2A13; AT1G67340; AT4G38940; SKIP15; AT3G16740; AT3G04660; AT1G78100; AT1G55000; SKIP16; SKIP2; SKIP32 AND EBF1. |
| [5] | "Members of the Arabidopsis-SKP1-like gene family exhibit a variety of expression patterns and may play diverse roles in Arabidopsis." Zhao D., Ni W., Feng B., Han T., Petrasek M.G., Ma H. Plant Physiol. 133:203-217(2003) [PubMed: 12970487] [Abstract] Cited for: FUNCTION, GENE FAMILY, NOMENCLATURE, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. |
| [6] | "Expression and interaction analysis of Arabidopsis Skp1-related genes." Takahashi N., Kuroda H., Kuromori T., Hirayama T., Seki M., Shinozaki K., Shimada H., Matsui M. Plant Cell Physiol. 45:83-91(2004) [PubMed: 14749489] [Abstract] Cited for: TISSUE SPECIFICITY, INTERACTION WITH EBF1/FBL6; COI1/FBL2; ADO3/FKF1; PP2B10; AT3G61590 AND AT5G49610. |
| [7] | "An F-box gene, CPR30, functions as a negative regulator of the defense response in Arabidopsis." Gou M., Su N., Zheng J., Huai J., Wu G., Zhao J., He J., Tang D., Yang S., Wang G. Plant J. 60:757-770(2009) [PubMed: 19682297] [Abstract] Cited for: INTERACTION WITH CPR30. |
| + | Additional computationally mapped references. |
Web resources
| PlantsUBQ A functional genomics database for the ubiquitin/26S proteasome proteolytic pathway in plants |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AL021961 Genomic DNA. Translation: CAA17551.1. AL161585 Genomic DNA. Translation: CAB80138.1. CP002687 Genomic DNA. Translation: AEE86340.1. DQ446893 mRNA. Translation: ABE66110.1. DQ653243 mRNA. Translation: ABK28664.1. Sequence problems. |
| IPI | IPI00541308. |
| PIR | T05415. |
| RefSeq | NP_567959.1. NM_119584.1. |
| UniGene | At.54598. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1FQV based on UniProtKB P63208. |
| ProteinModelPortal | O49484. |
| SMR | O49484. Positions 6-152. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | O49484. 35 interactions. |
| STRING | O49484. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblPlants | AT4G34210.1; AT4G34210.1; AT4G34210. |
| GeneID | 829569. |
| GenomeReviews | Gene locus AT4G34210 in contig CT486007_GR. |
| KEGG | ath:AT4G34210. |
| NMPDR | fig|3702.1.peg.21481. |
Organism-specific databases | |
| TAIR | At4g34210. |
Phylogenomic databases | |
| eggNOG | KOG1724. |
| GeneTree | EPGT00070000027986. |
| HOGENOM | HBG622018. |
| InParanoid | O49484. |
| OMA | HHVDEAN. |
| PhylomeDB | O49484. |
| ProtClustDB | CLSN2689755. |
Gene expression databases | |
| ArrayExpress | O49484. |
| Genevestigator | O49484. |
Family and domain databases | |
| InterPro | IPR011333. BTB/POZ_fold. IPR016897. E3_ubiquit_lig_SCF_Skp. IPR001232. Skp1_comp. IPR016072. Skp1_comp_dimer. IPR016073. Skp1_comp_POZ. [Graphical view] |
| Gene3D | G3DSA:3.30.710.10. BTB/POZ_fold. 1 hit. |
| KO | K03094. |
| PANTHER | PTHR11165. Skp1. 1 hit. |
| Pfam | PF01466. Skp1. 1 hit. PF03931. Skp1_POZ. 1 hit. [Graphical view] |
| PIRSF | PIRSF028729. E3_ubiquit_lig_SCF_Skp. 1 hit. |
| SMART | SM00512. Skp1. 1 hit. [Graphical view] |
| SUPFAM | SSF54695. BTB/POZ_fold. 1 hit. SSF81382. Skp1_comp_dimer. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | ASK11_ARATH | ||||||||
| Accession | Primary (citable) accession number: O49484 Secondary accession number(s): A0MFB7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Plant Protein Annotation Program | ||||||||
Relevant documents
| Arabidopsis thaliana Arabidopsis thaliana: entries and gene names |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with