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Protein

Prohibitin-1, mitochondrial

Gene

PHB1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Prohibitin-1, mitochondrial
Short name:
Atphb1
Gene namesi
Name:PHB1
Ordered Locus Names:At4g28510
ORF Names:F20O9.200
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G28510.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 109Mitochondrial matrixSequence analysis
Transmembranei11 – 3020Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini31 – 288258Mitochondrial intermembraneSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial respiratory chain complex I Source: TAIR
  • mitochondrion Source: TAIR
  • vacuolar membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 288287Prohibitin-1, mitochondrialPRO_0000420596Add
BLAST

Proteomic databases

PaxDbiO49460.
PRIDEiO49460.
ProMEXiO49460.

Expressioni

Tissue specificityi

Mostly expressed in proliferative tissues, including vasculature, shoot and root apical tissues.1 Publication

Gene expression databases

GenevisibleiO49460. AT.

Interactioni

Subunit structurei

Component of a prohibitin multimeric complex in mitochondrial membranes.3 Publications

Protein-protein interaction databases

BioGridi14256. 1 interaction.
IntActiO49460. 4 interactions.
STRINGi3702.AT4G28510.1.

Structurei

3D structure databases

ProteinModelPortaliO49460.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili186 – 21934Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the prohibitin family.Curated

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3090. Eukaryota.
COG0330. LUCA.
HOGENOMiHOG000205692.
InParanoidiO49460.
KOiK17081.
OMAiSMAERMM.
OrthoDBiEOG09360JXQ.
PhylomeDBiO49460.

Family and domain databases

InterProiIPR001107. Band_7.
IPR000163. Prohibitin.
[Graphical view]
PANTHERiPTHR23222. PTHR23222. 1 hit.
PfamiPF01145. Band_7. 1 hit.
[Graphical view]
PRINTSiPR00679. PROHIBITIN.
SMARTiSM00244. PHB. 1 hit.
[Graphical view]
SUPFAMiSSF117892. SSF117892. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O49460-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNVKVPKIP GGGAISTLLK VGIIGGLGLY GATHSLYNVE GGHRAIMFNR
60 70 80 90 100
LVGIKDKVYP EGTHLMIPWF ERPVIYDVRA RPYLVESTSG SRDLQMVKIG
110 120 130 140 150
LRVLTRPMAD QLPEIYRSLG ENYSERVLPS IINETLKAVV AQYNASQLIT
160 170 180 190 200
QREAVSREIR KILTERAANF NVALDDVSIT NLTFGKEFTA AIEAKQVAAQ
210 220 230 240 250
EAERAKFIVE KAEQDKRSAV IRAQGEAKSA QLIGQAIANN QAFITLRKIE
260 270 280
AAREIAQTIA NSANKVYLSS DDLLLNLQGM NLDVDAKN
Length:288
Mass (Da):31,706
Last modified:June 1, 1998 - v1
Checksum:iA08BE4720B6BF1A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66591 mRNA. Translation: AAD00155.1.
U66594 Genomic DNA. Translation: AAD00158.1.
AL021749 Genomic DNA. Translation: CAA16891.1.
AL161573 Genomic DNA. Translation: CAB81439.1.
CP002687 Genomic DNA. Translation: AEE85496.1.
AY093228 mRNA. Translation: AAM13227.1.
BT000211 mRNA. Translation: AAN15530.1.
AY088047 mRNA. Translation: AAM65593.1.
PIRiT04622.
RefSeqiNP_194580.1. NM_118993.3.
UniGeneiAt.2011.

Genome annotation databases

EnsemblPlantsiAT4G28510.1; AT4G28510.1; AT4G28510.
GeneIDi828969.
GrameneiAT4G28510.1; AT4G28510.1; AT4G28510.
KEGGiath:AT4G28510.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66591 mRNA. Translation: AAD00155.1.
U66594 Genomic DNA. Translation: AAD00158.1.
AL021749 Genomic DNA. Translation: CAA16891.1.
AL161573 Genomic DNA. Translation: CAB81439.1.
CP002687 Genomic DNA. Translation: AEE85496.1.
AY093228 mRNA. Translation: AAM13227.1.
BT000211 mRNA. Translation: AAN15530.1.
AY088047 mRNA. Translation: AAM65593.1.
PIRiT04622.
RefSeqiNP_194580.1. NM_118993.3.
UniGeneiAt.2011.

3D structure databases

ProteinModelPortaliO49460.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi14256. 1 interaction.
IntActiO49460. 4 interactions.
STRINGi3702.AT4G28510.1.

Proteomic databases

PaxDbiO49460.
PRIDEiO49460.
ProMEXiO49460.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G28510.1; AT4G28510.1; AT4G28510.
GeneIDi828969.
GrameneiAT4G28510.1; AT4G28510.1; AT4G28510.
KEGGiath:AT4G28510.

Organism-specific databases

TAIRiAT4G28510.

Phylogenomic databases

eggNOGiKOG3090. Eukaryota.
COG0330. LUCA.
HOGENOMiHOG000205692.
InParanoidiO49460.
KOiK17081.
OMAiSMAERMM.
OrthoDBiEOG09360JXQ.
PhylomeDBiO49460.

Miscellaneous databases

PROiO49460.

Gene expression databases

GenevisibleiO49460. AT.

Family and domain databases

InterProiIPR001107. Band_7.
IPR000163. Prohibitin.
[Graphical view]
PANTHERiPTHR23222. PTHR23222. 1 hit.
PfamiPF01145. Band_7. 1 hit.
[Graphical view]
PRINTSiPR00679. PROHIBITIN.
SMARTiSM00244. PHB. 1 hit.
[Graphical view]
SUPFAMiSSF117892. SSF117892. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPHB1_ARATH
AccessioniPrimary (citable) accession number: O49460
Secondary accession number(s): Q8LA39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2013
Last sequence update: June 1, 1998
Last modified: September 7, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.