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Protein

ADP,ATP carrier protein 3, mitochondrial

Gene

AAC3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei152 – 1521NucleotideBy similarity

GO - Molecular functioni

  • ATP:ADP antiporter activity Source: TAIR
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

  • purine nucleotide transport Source: TAIR
  • translation Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-ATH-422356. Regulation of insulin secretion.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP,ATP carrier protein 3, mitochondrial
Alternative name(s):
ADP/ATP translocase 3
Adenine nucleotide translocator 3
Short name:
ANT 3
Gene namesi
Name:AAC3
Synonyms:ANT3
Ordered Locus Names:At4g28390
ORF Names:F20O9.60
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G28390.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei76 – 11035Helical; Name=1By similarityAdd
BLAST
Transmembranei147 – 17125Helical; Name=2By similarityAdd
BLAST
Transmembranei180 – 21435Helical; Name=3By similarityAdd
BLAST
Transmembranei249 – 27628Helical; Name=4By similarityAdd
BLAST
Transmembranei281 – 31535Helical; Name=5By similarityAdd
BLAST
Transmembranei344 – 36926Helical; Name=6By similarityAdd
BLAST

GO - Cellular componenti

  • chloroplast envelope Source: TAIR
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: TAIR
  • mitochondrial inner membrane Source: UniProtKB-SubCell
  • mitochondrion Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 6969MitochondrionSequence analysisAdd
BLAST
Chaini70 – 379310ADP,ATP carrier protein 3, mitochondrialPRO_0000410472Add
BLAST

Proteomic databases

PaxDbiO49447.
PRIDEiO49447.

PTM databases

SwissPalmiO49447.

Expressioni

Gene expression databases

GenevisibleiO49447. AT.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi14242. 3 interactions.
IntActiO49447. 1 interaction.
STRINGi3702.AT4G28390.1.

Structurei

3D structure databases

ProteinModelPortaliO49447.
SMRiO49447. Positions 80-366.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati77 – 17094Solcar 1Add
BLAST
Repeati182 – 27493Solcar 2Add
BLAST
Repeati282 – 36887Solcar 3Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi309 – 3146Substrate recognitionBy similarity

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0749. Eukaryota.
ENOG410XNW0. LUCA.
HOGENOMiHOG000165727.
InParanoidiO49447.
KOiK05863.
OMAiDCLMKVI.
PhylomeDBiO49447.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O49447-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGSKHPSVF QKLHGQSYLI NRLSPSVQAR GYCVSGAYVN GGLQSLLQPT
60 70 80 90 100
SHGVGSSLIP HGSFPVLAHA PSEKTGTGFL IDFLMGGVSA AVSKTAAAPI
110 120 130 140 150
ERVKLLIQNQ DEMIKAGRLS EPYKGISDCF ARTVKDEGML ALWRGNTANV
160 170 180 190 200
IRYFPTQALN FAFKDYFKRL FNFKKEKDGY WKWFAGNLAS GGAAGASSLL
210 220 230 240 250
FVYSLDYART RLANDAKAAK KGGQRQFNGM VDVYKKTIAS DGIVGLYRGF
260 270 280 290 300
NISCVGIVVY RGLYFGLYDS LKPVVLVDGL QDSFLASFLL GWGITIGAGL
310 320 330 340 350
ASYPIDTVRR RMMMTSGEAV KYKSSLQAFS QIVKNEGAKS LFKGAGANIL
360 370
RAVAGAGVLA GYDKLQLIVL GKKYGSGGG
Length:379
Mass (Da):40,718
Last modified:June 1, 1998 - v1
Checksum:iC865FEAD6968A2A9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti82 – 821D → Y in AAM65696 (Ref. 4) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL021749 Genomic DNA. Translation: CAA16877.1.
AL161572 Genomic DNA. Translation: CAB79641.1.
CP002687 Genomic DNA. Translation: AEE85477.1.
AK118017 mRNA. Translation: BAC42650.1.
AY088151 mRNA. Translation: AAM65696.1.
PIRiT04608.
RefSeqiNP_194568.1. NM_118980.3.
UniGeneiAt.44823.
At.69694.

Genome annotation databases

EnsemblPlantsiAT4G28390.1; AT4G28390.1; AT4G28390.
GeneIDi828955.
GrameneiAT4G28390.1; AT4G28390.1; AT4G28390.
KEGGiath:AT4G28390.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL021749 Genomic DNA. Translation: CAA16877.1.
AL161572 Genomic DNA. Translation: CAB79641.1.
CP002687 Genomic DNA. Translation: AEE85477.1.
AK118017 mRNA. Translation: BAC42650.1.
AY088151 mRNA. Translation: AAM65696.1.
PIRiT04608.
RefSeqiNP_194568.1. NM_118980.3.
UniGeneiAt.44823.
At.69694.

3D structure databases

ProteinModelPortaliO49447.
SMRiO49447. Positions 80-366.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi14242. 3 interactions.
IntActiO49447. 1 interaction.
STRINGi3702.AT4G28390.1.

PTM databases

SwissPalmiO49447.

Proteomic databases

PaxDbiO49447.
PRIDEiO49447.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G28390.1; AT4G28390.1; AT4G28390.
GeneIDi828955.
GrameneiAT4G28390.1; AT4G28390.1; AT4G28390.
KEGGiath:AT4G28390.

Organism-specific databases

TAIRiAT4G28390.

Phylogenomic databases

eggNOGiKOG0749. Eukaryota.
ENOG410XNW0. LUCA.
HOGENOMiHOG000165727.
InParanoidiO49447.
KOiK05863.
OMAiDCLMKVI.
PhylomeDBiO49447.

Enzyme and pathway databases

ReactomeiR-ATH-422356. Regulation of insulin secretion.

Miscellaneous databases

PROiO49447.

Gene expression databases

GenevisibleiO49447. AT.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana."
    Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B.
    , Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R.
    Nature 402:769-777(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins."
    Heazlewood J.L., Tonti-Filippini J.S., Gout A.M., Day D.A., Whelan J., Millar A.H.
    Plant Cell 16:241-256(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Strain: cv. Landsberg erecta.
  6. "The growing family of mitochondrial carriers in Arabidopsis."
    Picault N., Hodges M., Palmieri L., Palmieri F.
    Trends Plant Sci. 9:138-146(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY.

Entry informationi

Entry nameiADT3_ARATH
AccessioniPrimary (citable) accession number: O49447
Secondary accession number(s): Q8L9Y1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 1, 1998
Last modified: July 6, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. At least 2 of the odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue (By similarity).By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.