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Protein

ADP,ATP carrier protein 3, mitochondrial

Gene

AAC3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei152ADPBy similarity1
Binding sitei164ADPBy similarity1
Binding sitei309ADPBy similarity1

GO - Molecular functioni

  • ATP:ADP antiporter activity Source: TAIR

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
ADP,ATP carrier protein 3, mitochondrial
Alternative name(s):
ADP/ATP translocase 3
Adenine nucleotide translocator 3
Short name:
ANT 3
Gene namesi
Name:AAC3
Synonyms:ANT3
Ordered Locus Names:At4g28390
ORF Names:F20O9.60
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G28390
TAIRilocus:2121363 AT4G28390

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei79 – 106Helical; Name=1By similarityAdd BLAST28
Transmembranei147 – 171Helical; Name=2By similarityAdd BLAST25
Transmembranei180 – 200Helical; Name=3By similarityAdd BLAST21
Transmembranei250 – 271Helical; Name=4By similarityAdd BLAST22
Transmembranei285 – 305Helical; Name=5By similarityAdd BLAST21
Transmembranei345 – 365Helical; Name=6By similarityAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 69MitochondrionSequence analysisAdd BLAST69
ChainiPRO_000041047270 – 379ADP,ATP carrier protein 3, mitochondrialAdd BLAST310

Proteomic databases

PaxDbiO49447
PRIDEiO49447

PTM databases

SwissPalmiO49447

Expressioni

Gene expression databases

ExpressionAtlasiO49447 baseline and differential
GenevisibleiO49447 AT

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi14242, 3 interactors
IntActiO49447, 1 interactor
STRINGi3702.AT4G28390.1

Structurei

3D structure databases

ProteinModelPortaliO49447
SMRiO49447
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati77 – 170Solcar 1Add BLAST94
Repeati182 – 274Solcar 2Add BLAST93
Repeati282 – 368Solcar 3Add BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni309 – 314Important for transport activityBy similarity6

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi309 – 314Nucleotide carrier signature motifBy similarity6

Domaini

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. At least 2 of the odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat, Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0749 Eukaryota
ENOG410XNW0 LUCA
HOGENOMiHOG000165727
InParanoidiO49447
KOiK05863
OMAiNCIAKIF
OrthoDBiEOG09360DZB
PhylomeDBiO49447

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002113 Aden_trnslctor
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00927 ADPTRNSLCASE
PR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O49447-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGSKHPSVF QKLHGQSYLI NRLSPSVQAR GYCVSGAYVN GGLQSLLQPT
60 70 80 90 100
SHGVGSSLIP HGSFPVLAHA PSEKTGTGFL IDFLMGGVSA AVSKTAAAPI
110 120 130 140 150
ERVKLLIQNQ DEMIKAGRLS EPYKGISDCF ARTVKDEGML ALWRGNTANV
160 170 180 190 200
IRYFPTQALN FAFKDYFKRL FNFKKEKDGY WKWFAGNLAS GGAAGASSLL
210 220 230 240 250
FVYSLDYART RLANDAKAAK KGGQRQFNGM VDVYKKTIAS DGIVGLYRGF
260 270 280 290 300
NISCVGIVVY RGLYFGLYDS LKPVVLVDGL QDSFLASFLL GWGITIGAGL
310 320 330 340 350
ASYPIDTVRR RMMMTSGEAV KYKSSLQAFS QIVKNEGAKS LFKGAGANIL
360 370
RAVAGAGVLA GYDKLQLIVL GKKYGSGGG
Length:379
Mass (Da):40,718
Last modified:June 1, 1998 - v1
Checksum:iC865FEAD6968A2A9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti82D → Y in AAM65696 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL021749 Genomic DNA Translation: CAA16877.1
AL161572 Genomic DNA Translation: CAB79641.1
CP002687 Genomic DNA Translation: AEE85477.1
CP002687 Genomic DNA Translation: ANM66258.1
AK118017 mRNA Translation: BAC42650.1
AY088151 mRNA Translation: AAM65696.1
PIRiT04608
RefSeqiNP_001328166.1, NM_001341915.1
NP_194568.1, NM_118980.4
UniGeneiAt.44823
At.69694

Genome annotation databases

EnsemblPlantsiAT4G28390.1; AT4G28390.1; AT4G28390
AT4G28390.2; AT4G28390.2; AT4G28390
GeneIDi828955
GrameneiAT4G28390.1; AT4G28390.1; AT4G28390
AT4G28390.2; AT4G28390.2; AT4G28390
KEGGiath:AT4G28390

Similar proteinsi

Entry informationi

Entry nameiADT3_ARATH
AccessioniPrimary (citable) accession number: O49447
Secondary accession number(s): Q8L9Y1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 1, 1998
Last modified: April 25, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health