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Protein

Heat stress transcription factor A-4a

Gene

HSFA4A

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional activator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi13 – 107By similarityAdd BLAST95

GO - Molecular functioni

  • DNA binding transcription factor activity Source: TAIR
  • protein homodimerization activity Source: TAIR
  • sequence-specific DNA binding Source: InterPro

GO - Biological processi

  • positive regulation of transcription, DNA-templated Source: TAIR
  • regulation of transcription, DNA-templated Source: TAIR
  • response to chitin Source: TAIR
  • response to reactive oxygen species Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding
Biological processStress response, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-ATH-3371453 Regulation of HSF1-mediated heat shock response
R-ATH-3371511 HSF1 activation
R-ATH-3371568 Attenuation phase
R-ATH-3371571 HSF1-dependent transactivation

Names & Taxonomyi

Protein namesi
Recommended name:
Heat stress transcription factor A-4a
Short name:
AtHsfA4a
Alternative name(s):
AtHsf-15
Heat shock factor protein 21
Short name:
HSF 21
Heat shock transcription factor 21
Short name:
HSTF 21
Gene namesi
Name:HSFA4A
Synonyms:HSF15, HSF21
Ordered Locus Names:At4g18880
ORF Names:F13C5.50
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G18880
TAIRilocus:2117139 AT4G18880

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002708041 – 401Heat stress transcription factor A-4aAdd BLAST401

Post-translational modificationi

Exhibits temperature-dependent phosphorylation.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO49403
PRIDEiO49403

PTM databases

iPTMnetiO49403

Expressioni

Gene expression databases

ExpressionAtlasiO49403 baseline and differential
GenevisibleiO49403 AT

Interactioni

Subunit structurei

Homotrimer.By similarity

GO - Molecular functioni

  • protein homodimerization activity Source: TAIR

Protein-protein interaction databases

BioGridi12915, 3 interactors
STRINGi3702.AT4G18880.1

Structurei

3D structure databases

ProteinModelPortaliO49403
SMRiO49403
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni122 – 188Hydrophobic repeat HR-A/BAdd BLAST67

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi207 – 213Nuclear localization signalSequence analysis7
Motifi256 – 265AHA110
Motifi341 – 350AHA210
Motifi388 – 395Nuclear export signalSequence analysis8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi331 – 335Poly-Pro5

Domaini

The hydrophobic-rich region (HR-A/B) corresponds to the oligomerization domain. AHA motifs are transcriptional activator elements.1 Publication

Sequence similaritiesi

Belongs to the HSF family. Class A subfamily.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0627 Eukaryota
COG5169 LUCA
HOGENOMiHOG000237979
InParanoidiO49403
KOiK09419
OMAiMNNQIER
OrthoDBiEOG09360EZK
PhylomeDBiO49403

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000232 HSF_DNA-bd
IPR027725 HSF_fam
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR10015 PTHR10015, 2 hits
PfamiView protein in Pfam
PF00447 HSF_DNA-bind, 1 hit
PRINTSiPR00056 HSFDOMAIN
SMARTiView protein in SMART
SM00415 HSF, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit

Sequencei

Sequence statusi: Complete.

O49403-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDENNHGVSS SSLPPFLTKT YEMVDDSSSD SIVSWSQSNK SFIVWNPPEF
60 70 80 90 100
SRDLLPRFFK HNNFSSFIRQ LNTYGFRKAD PEQWEFANDD FVRGQPHLMK
110 120 130 140 150
NIHRRKPVHS HSLPNLQAQL NPLTDSERVR MNNQIERLTK EKEGLLEELH
160 170 180 190 200
KQDEEREVFE MQVKELKERL QHMEKRQKTM VSFVSQVLEK PGLALNLSPC
210 220 230 240 250
VPETNERKRR FPRIEFFPDE PMLEENKTCV VVREEGSTSP SSHTREHQVE
260 270 280 290 300
QLESSIAIWE NLVSDSCESM LQSRSMMTLD VDESSTFPES PPLSCIQLSV
310 320 330 340 350
DSRLKSPPSP RIIDMNCEPD GSKEQNTVAA PPPPPVAGAN DGFWQQFFSE
360 370 380 390 400
NPGSTEQREV QLERKDDKDK AGVRTEKCWW NSRNVNAITE QLGHLTSSER

S
Length:401
Mass (Da):46,245
Last modified:June 1, 1998 - v1
Checksum:iB3F7105DC1CBBB87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL021711 Genomic DNA Translation: CAA16745.1
AL161549 Genomic DNA Translation: CAB78890.1
CP002687 Genomic DNA Translation: AEE84101.1
AY125512 mRNA Translation: AAM78104.1
BT001049 mRNA Translation: AAN46803.1
U68561 mRNA Translation: AAC31792.1
PIRiT05025
RefSeqiNP_193623.1, NM_118004.3
UniGeneiAt.1951

Genome annotation databases

EnsemblPlantsiAT4G18880.1; AT4G18880.1; AT4G18880
GeneIDi827622
GrameneiAT4G18880.1; AT4G18880.1; AT4G18880
KEGGiath:AT4G18880

Similar proteinsi

Entry informationi

Entry nameiHFA4A_ARATH
AccessioniPrimary (citable) accession number: O49403
Secondary accession number(s): O82078
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: June 1, 1998
Last modified: May 23, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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