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Protein

Cytochrome P450 82C2

Gene

CYP82C2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the biosynthetic pathway to 4-hydroxyindole-3-carbonyl nitrile (4-OH-ICN), a cyanogenic metabolite required for inducible pathogen defense. Converts indole-3-carbonyl nitrile (ICN) into 4-OH-ICN (PubMed:26352477). Can hydroxylate 8-methoxypsoralen to form 5-hydroxy-8-methoxypsoralen in vivo and in vitro (PubMed:18291319).2 Publications

Miscellaneous

Plants overexpressing CYP82C2, can hydroxylate and subsequently glycosylate 8-methoxypsoralen.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi462Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

  • cellular response to hypoxia Source: TAIR
  • secondary metabolite biosynthetic process Source: GO_Central

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT4G31970-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 82C2 (EC:1.14.-.-)
Gene namesi
Name:CYP82C2
Ordered Locus Names:At4g31970
ORF Names:F10N7.220
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G31970
TAIRilocus:2116652 AT4G31970

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Increased susceptibility to virulent Pseudomonas syringae.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004111971 – 523Cytochrome P450 82C2Add BLAST523

Proteomic databases

PaxDbiO49394

Expressioni

Inductioni

Up-regulated upon pathogen infection.1 Publication

Gene expression databases

ExpressionAtlasiO49394 baseline and differential
GenevisibleiO49394 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT4G31970.1

Structurei

3D structure databases

ProteinModelPortaliO49394
SMRiO49394
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
HOGENOMiHOG000218627
InParanoidiO49394
OMAiEARQCRK
OrthoDBiEOG0936087W
PhylomeDBiO49394

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

O49394-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTSLFSLFV PILVFVFIAL FKKSKKPKHV KAPAPSGAWP IIGHLHLLSG
60 70 80 90 100
KEQLLYRTLG KMADQYGPAM SLRLGSSETF VVSSFEVAKD CFTVNDKALA
110 120 130 140 150
SRPITAAAKH MGYDCAVFGF APYSAFWREM RKIATLELLS NRRLQMLKHV
160 170 180 190 200
RVSEISMVMQ DLYSLWVKKG GSEPVMVDLK SWLEDMSLNM MVRMVAGKRY
210 220 230 240 250
FGGGSLSPED AEEARQCRKG VANFFHLVGI FTVSDAFPKL GWFDFQGHEK
260 270 280 290 300
EMKQTGRELD VILERWIENH RQQRKVSGTK HNDSDFVDVM LSLAEQGKFS
310 320 330 340 350
HLQHDAITSI KSTCLALILG GSETSPSTLT WAISLLLNNK DMLKKAQDEI
360 370 380 390 400
DIHVGRDRNV EDSDIENLVY IQAIIKETLR LYPAGPLLGH REAIEDCTVA
410 420 430 440 450
GYNVRRGTRM LVNVWKIQRD PRVYMEPNEF RPERFITGEA KEFDVRGQNF
460 470 480 490 500
ELMPFGSGRR SCPGSSLAMQ VLHLGLARFL QSFDVKTVMD MPVDMTESPG
510 520
LTIPKATPLE ILISPRLKEG LYV
Length:523
Mass (Da):59,002
Last modified:January 1, 1999 - v2
Checksum:i0FE5D79217DFDAA9
GO

Sequence cautioni

The sequence ABK28662 differs from that shown. Reason: Erroneous termination at position 524. Translated as stop.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL021636 Genomic DNA Translation: CAA16592.1
AL161580 Genomic DNA Translation: CAB79915.1
CP002687 Genomic DNA Translation: AEE85984.1
DQ653241 mRNA Translation: ABK28662.1 Sequence problems.
PIRiT04648
RefSeqiNP_194925.1, NM_119348.2
UniGeneiAt.49411

Genome annotation databases

EnsemblPlantsiAT4G31970.1; AT4G31970.1; AT4G31970
GeneIDi829327
GrameneiAT4G31970.1; AT4G31970.1; AT4G31970
KEGGiath:AT4G31970

Similar proteinsi

Entry informationi

Entry nameiC82C2_ARATH
AccessioniPrimary (citable) accession number: O49394
Secondary accession number(s): A0MFB5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: January 1, 1999
Last modified: April 25, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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