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Protein

Cytochrome P450 71A12

Gene

CYP71A12

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Converts indole-3-acetaldoxime to indole cyanohydrin. Involved in the biosynthetic pathway to 4-hydroxyindole-3-carbonyl nitrile (4-OH-ICN), a cyanogenic metabolite required for inducible pathogen defense.1 Publication

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi439Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 71A12 (EC:1.14.-.-Curated)
Gene namesi
Name:CYP71A12
Ordered Locus Names:At2g30750
ORF Names:T11J7.14
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G30750

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

90% decrease of all indole-3-carbonyl nitrile (ICN) derivatives and increased susceptibility to virulent Pseudomonas syringae.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000520631 – 497Cytochrome P450 71A12Add BLAST497

Proteomic databases

PaxDbiO49340
PRIDEiO49340

Expressioni

Gene expression databases

ExpressionAtlasiO49340 baseline and differential
GenevisibleiO49340 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G30750.1

Structurei

3D structure databases

ProteinModelPortaliO49340
SMRiO49340
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi164 – 169Poly-Ser6

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
HOGENOMiHOG000218629
InParanoidiO49340
KOiK11868
OrthoDBiEOG09360BN4
PhylomeDBiO49340

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

O49340-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMILMVSLC LTTLITLFLL KQFLKRTANK VNLPPSPWRL PLIGNLHQLS
60 70 80 90 100
LHPHRSLHSL SLRYGPLMLL HFGRVPILVV SSGEAAQEVL KTHDLKFANR
110 120 130 140 150
PRSKAVHGLM NGGRDVVFGP YGEYWRQMKS VCILNLLTNK MVASFEKIRE
160 170 180 190 200
EELNEMIKKL EKASSSSSSE NLSELFVTLP SDVTSRIALG RKHSEDETAR
210 220 230 240 250
DLKKRVRQIM ELLGEFPIGD YVPALAWIDR INGFNARIKE VSQGFSDLMD
260 270 280 290 300
KVVQEHLEAG NHKEDFVDIL LSIESEKSIG FQAQRDDIKF MILDMFIGGT
310 320 330 340 350
STSSTLLEWI MTELIRNPNV MKKLQDEIRS TIRPHGSYIK EKDVENMKYL
360 370 380 390 400
KAVIKEVFRV HPPLPLILPR LLSEDVKVKG YNIAAGTEVI INAWAIQRDP
410 420 430 440 450
AIWGPDAEEF KPERHLDSTL DYHGKDLNFI PFGSGRRICP GINLALGLVE
460 470 480 490
VTVANLVGRF DWRAEAGPNG DQPDLTEAFG LDVCRKFPLI AFPSSVI
Length:497
Mass (Da):56,152
Last modified:June 1, 1998 - v1
Checksum:iBE6AC1A28A737C81
GO

Sequence cautioni

The sequence AAM19850 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAN46800 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002340 Genomic DNA Translation: AAC02746.1
CP002685 Genomic DNA Translation: AEC08435.2
AY094484 mRNA Translation: AAM19850.1 Different initiation.
BT001046 mRNA Translation: AAN46800.1 Different initiation.
PIRiC84712
RefSeqiNP_180633.3, NM_128628.4
UniGeneiAt.38323

Genome annotation databases

EnsemblPlantsiAT2G30750.1; AT2G30750.1; AT2G30750
GeneIDi817626
GrameneiAT2G30750.1; AT2G30750.1; AT2G30750
KEGGiath:AT2G30750

Similar proteinsi

Entry informationi

Entry nameiC71AC_ARATH
AccessioniPrimary (citable) accession number: O49340
Secondary accession number(s): F4INX7, Q8LPP9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: June 1, 1998
Last modified: April 25, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health