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Protein

PTI1-like tyrosine-protein kinase 2

Gene

PTI12

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable tyrosine-protein kinase involved in oxidative burst-mediated signaling leading to specific genes expression.1 Publication

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Enzyme regulationi

Strongly activated in response to phosphatidic acid (PA) and xylanase in a OXI1- and PDK1-dependent manner, and, to a lesser extent, by hydrogen peroxide and flagellin in a OXI1-dependent manner.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei99ATPCurated1
Active sitei203Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi77 – 85ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinase
Biological processPlant defense
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
PTI1-like tyrosine-protein kinase 2 (EC:2.7.10.2)
Short name:
PTI1-2
Gene namesi
Name:PTI12
Ordered Locus Names:At2g30740
ORF Names:T11J7.13
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G30740
TAIRilocus:2054502 AT2G30740

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi99K → N: Reduced phosphorylation and impaired kinase activity. No phosphorylation; when associated with A-238. 1 Publication1
Mutagenesisi238T → A: No phosphorylation; when associated with N-99. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004033231 – 366PTI1-like tyrosine-protein kinase 2Add BLAST366

Post-translational modificationi

Autophosphorylated and phosphorylated by OXI1.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO49339
PRIDEiO49339

PTM databases

iPTMnetiO49339
SwissPalmiO49339

Expressioni

Gene expression databases

ExpressionAtlasiO49339 baseline and differential
GenevisibleiO49339 AT

Interactioni

Subunit structurei

Interacts with OXI1.1 Publication

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi2974, 2 interactors
STRINGi3702.AT2G30740.1

Structurei

3D structure databases

ProteinModelPortaliO49339
SMRiO49339
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini71 – 353Protein kinasePROSITE-ProRule annotationAdd BLAST283

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1187 Eukaryota
COG0515 LUCA
HOGENOMiHOG000116550
InParanoidiO49339
OMAiWQNSEAN
OrthoDBiEOG09360DYR
PhylomeDBiO49339

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
SMARTiView protein in SMART
SM00219 TyrKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequencei

Sequence statusi: Complete.

O49339-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRWICCGDK KGDSDLSNEE VHLKSPWQNS EANQKNQKPQ AVVKPEAQKE
60 70 80 90 100
ALPIEVPPLS VDEVKEKTDN FGSKSLIGEG SYGRVYYATL NDGKAVALKK
110 120 130 140 150
LDVAPEAETN TEFLNQVSMV SRLKHENLIQ LVGYCVDENL RVLAYEFATM
160 170 180 190 200
GSLHDILHGR KGVQGAQPGP TLDWLTRVKI AVEAARGLEY LHEKVQPPVI
210 220 230 240 250
HRDIRSSNVL LFEDYQAKVA DFNLSNQAPD NAARLHSTRV LGTFGYHAPE
260 270 280 290 300
YAMTGQLTQK SDVYSFGVVL LELLTGRKPV DHTMPRGQQS LVTWATPRLS
310 320 330 340 350
EDKVKQCVDP KLKGEYPPKS VAKLAAVAAL CVQYESEFRP NMSIVVKALQ
360
PLLKPPAPAP APVPES
Length:366
Mass (Da):40,500
Last modified:June 1, 1998 - v1
Checksum:iE9A0450069D35C72
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ303007 mRNA Translation: CAC34450.1
AC002340 Genomic DNA Translation: AAC02745.1
CP002685 Genomic DNA Translation: AEC08434.1
CP002685 Genomic DNA Translation: ANM62808.1
CP002685 Genomic DNA Translation: ANM62809.1
CP002685 Genomic DNA Translation: ANM62810.1
CP002685 Genomic DNA Translation: ANM62811.1
CP002685 Genomic DNA Translation: ANM62812.1
CP002685 Genomic DNA Translation: ANM62813.1
CP002685 Genomic DNA Translation: ANM62814.1
CP002685 Genomic DNA Translation: ANM62815.1
CP002685 Genomic DNA Translation: ANM62816.1
CP002685 Genomic DNA Translation: ANM62817.1
CP002685 Genomic DNA Translation: ANM62818.1
CP002685 Genomic DNA Translation: ANM62819.1
CP002685 Genomic DNA Translation: ANM62820.1
CP002685 Genomic DNA Translation: ANM62821.1
BT024893 mRNA Translation: ABD85164.1
AK230305 mRNA Translation: BAF02106.1
PIRiB84712
RefSeqiNP_001318322.1, NM_001336285.1
NP_001324937.1, NM_001336289.1
NP_001324938.1, NM_001336288.1
NP_001324939.1, NM_001336287.1
NP_001324940.1, NM_001336291.1
NP_001324941.1, NM_001336286.1
NP_001324942.1, NM_001336290.1
NP_001324943.1, NM_001336297.1
NP_001324944.1, NM_001336296.1
NP_001324945.1, NM_001336295.1
NP_001324946.1, NM_001336294.1
NP_001324947.1, NM_001336293.1
NP_001324948.1, NM_001336292.1
NP_001324949.1, NM_001336299.1
NP_001324950.1, NM_001336298.1
UniGeneiAt.20728

Genome annotation databases

EnsemblPlantsiAT2G30740.1; AT2G30740.1; AT2G30740
AT2G30740.10; AT2G30740.10; AT2G30740
AT2G30740.11; AT2G30740.11; AT2G30740
AT2G30740.12; AT2G30740.12; AT2G30740
AT2G30740.13; AT2G30740.13; AT2G30740
AT2G30740.14; AT2G30740.14; AT2G30740
AT2G30740.15; AT2G30740.15; AT2G30740
AT2G30740.2; AT2G30740.2; AT2G30740
AT2G30740.3; AT2G30740.3; AT2G30740
AT2G30740.4; AT2G30740.4; AT2G30740
AT2G30740.5; AT2G30740.5; AT2G30740
AT2G30740.6; AT2G30740.6; AT2G30740
AT2G30740.7; AT2G30740.7; AT2G30740
AT2G30740.8; AT2G30740.8; AT2G30740
AT2G30740.9; AT2G30740.9; AT2G30740
GeneIDi817625
GrameneiAT2G30740.1; AT2G30740.1; AT2G30740
AT2G30740.10; AT2G30740.10; AT2G30740
AT2G30740.11; AT2G30740.11; AT2G30740
AT2G30740.12; AT2G30740.12; AT2G30740
AT2G30740.13; AT2G30740.13; AT2G30740
AT2G30740.14; AT2G30740.14; AT2G30740
AT2G30740.15; AT2G30740.15; AT2G30740
AT2G30740.2; AT2G30740.2; AT2G30740
AT2G30740.3; AT2G30740.3; AT2G30740
AT2G30740.4; AT2G30740.4; AT2G30740
AT2G30740.5; AT2G30740.5; AT2G30740
AT2G30740.6; AT2G30740.6; AT2G30740
AT2G30740.7; AT2G30740.7; AT2G30740
AT2G30740.8; AT2G30740.8; AT2G30740
AT2G30740.9; AT2G30740.9; AT2G30740
KEGGiath:AT2G30740

Similar proteinsi

Entry informationi

Entry nameiPTI12_ARATH
AccessioniPrimary (citable) accession number: O49339
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: June 1, 1998
Last modified: May 23, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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