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Protein

Probable phosphoglucomutase, cytoplasmic 1

Gene

At1g23190

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

This enzyme participates in both the breakdown and synthesis of glucose.By similarity

Catalytic activityi

Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei20 – 201SubstrateBy similarity
Binding sitei24 – 241SubstrateBy similarity
Active sitei123 – 1231Phosphoserine intermediateBy similarity
Metal bindingi123 – 1231Magnesium; via phosphate groupBy similarity
Binding sitei136 – 1361SubstrateBy similarity
Metal bindingi299 – 2991MagnesiumBy similarity
Metal bindingi301 – 3011MagnesiumBy similarity
Metal bindingi303 – 3031MagnesiumBy similarity
Binding sitei367 – 3671SubstrateBy similarity
Binding sitei399 – 3991SubstrateBy similarity
Binding sitei536 – 5361SubstrateBy similarity

GO - Molecular functioni

  • magnesium ion binding Source: InterPro
  • phosphoglucomutase activity Source: TAIR

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT1G23190-MONOMER.
BRENDAi5.4.2.2. 399.
ReactomeiR-ATH-3322077. Glycogen synthesis.
R-ATH-70221. Glycogen breakdown (glycogenolysis).
R-ATH-70370. Galactose catabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phosphoglucomutase, cytoplasmic 1 (EC:5.4.2.2)
Short name:
PGM 1
Alternative name(s):
Glucose phosphomutase 1
Gene namesi
Ordered Locus Names:At1g23190
ORF Names:F26F24.1, T26J12.5
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G23190.

Subcellular locationi

GO - Cellular componenti

  • chloroplast Source: TAIR
  • chloroplast stroma Source: GO_Central
  • cytoplasm Source: TAIR
  • cytosol Source: TAIR
  • nucleus Source: TAIR
  • plasma membrane Source: TAIR
  • stromule Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 583583Probable phosphoglucomutase, cytoplasmic 1PRO_0000147798Add
BLAST

Proteomic databases

PaxDbiO49299.
PRIDEiO49299.

PTM databases

iPTMnetiO49299.

Expressioni

Gene expression databases

GenevisibleiO49299. AT.

Interactioni

Protein-protein interaction databases

BioGridi24166. 7 interactions.
IntActiO49299. 3 interactions.
STRINGi3702.AT1G23190.1.

Structurei

3D structure databases

ProteinModelPortaliO49299.
SMRiO49299. Positions 4-583.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni123 – 1242Substrate bindingBy similarity
Regioni303 – 3042Substrate bindingBy similarity
Regioni386 – 3883Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the phosphohexose mutase family.Curated

Phylogenomic databases

eggNOGiKOG0625. Eukaryota.
COG0033. LUCA.
HOGENOMiHOG000009550.
InParanoidiO49299.
KOiK01835.
OMAiACKNREN.
OrthoDBiEOG0936067I.
PhylomeDBiO49299.

Family and domain databases

Gene3Di3.30.310.50. 1 hit.
3.40.120.10. 3 hits.
InterProiIPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005845. A-D-PHexomutase_a/b/a-II.
IPR005846. A-D-PHexomutase_a/b/a-III.
IPR005843. A-D-PHexomutase_C.
IPR016066. A-D-PHexomutase_CS.
IPR005841. Alpha-D-phosphohexomutase_SF.
[Graphical view]
PfamiPF02878. PGM_PMM_I. 1 hit.
PF02879. PGM_PMM_II. 1 hit.
PF02880. PGM_PMM_III. 1 hit.
PF00408. PGM_PMM_IV. 1 hit.
[Graphical view]
PRINTSiPR00509. PGMPMM.
SUPFAMiSSF53738. SSF53738. 3 hits.
SSF55957. SSF55957. 1 hit.
PROSITEiPS00710. PGM_PMM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O49299-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVFKVSTVST SPIDGQKPGT SGLRKKVKVF KQPNYLENFV QATFNALTAE
60 70 80 90 100
KVKGATLVVS GDGRYYSKDA VQIIIKMAAA NGVRRVWVGK NTLLSTPAVS
110 120 130 140 150
AVIRERSGAD GSKATGAFIL TASHNPGGPT EDFGIKYNME NGGPAPESIT
160 170 180 190 200
DKIYENTKTI KEYPIAQDLP NVDISAVGVT SFEGPEGKFD VEVFDPADDY
210 220 230 240 250
VKLMKSIFDF EAIRKLLSSP KFTFCYDALH GVAGAYAHRI FVEELGAQES
260 270 280 290 300
ALLNCTPKED FGGGHPDPNL TYAKELVARM GLGKSDTGGE PPEFGAAADG
310 320 330 340 350
DADRNMILGK RFFVTPSDSV AIIAANAIGA IPYFSSGLKG VARSMPTSAA
360 370 380 390 400
LDVVAKSLNL KFFEVPTGWK FFGNLMDAGM CSVCGEESFG TGSDHIREKD
410 420 430 440 450
GIWAVLAWMS ILAHKNKGNI DGNAKLVSVE DIVRQHWATY GRHYYTRYDY
460 470 480 490 500
ENVDAGKAKE LMEHLVKLQS SIPEVNKIVK GIRSDVASVA SADEFEYKDP
510 520 530 540 550
VDGSISKHQG IRYLFEDGSR LVFRLSGTGS EGATIRLYIE QYEKDASKTG
560 570 580
RESQEALSPL VDLALKLSKM EEFTGRSAPT VIT
Length:583
Mass (Da):63,171
Last modified:February 8, 2011 - v2
Checksum:i3D39B37F75FA7F90
GO

Sequence cautioni

The sequence AAC00601 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence AAF86992 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002311 Genomic DNA. Translation: AAC00601.1. Sequence problems.
AC005292 Genomic DNA. Translation: AAF86992.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE30353.1.
AY059926 mRNA. Translation: AAL24408.1.
AY081589 mRNA. Translation: AAM10151.1.
PIRiB86366.
RefSeqiNP_173732.1. NM_102167.3.
UniGeneiAt.25429.

Genome annotation databases

EnsemblPlantsiAT1G23190.1; AT1G23190.1; AT1G23190.
GeneIDi838927.
GrameneiAT1G23190.1; AT1G23190.1; AT1G23190.
KEGGiath:AT1G23190.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002311 Genomic DNA. Translation: AAC00601.1. Sequence problems.
AC005292 Genomic DNA. Translation: AAF86992.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE30353.1.
AY059926 mRNA. Translation: AAL24408.1.
AY081589 mRNA. Translation: AAM10151.1.
PIRiB86366.
RefSeqiNP_173732.1. NM_102167.3.
UniGeneiAt.25429.

3D structure databases

ProteinModelPortaliO49299.
SMRiO49299. Positions 4-583.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi24166. 7 interactions.
IntActiO49299. 3 interactions.
STRINGi3702.AT1G23190.1.

PTM databases

iPTMnetiO49299.

Proteomic databases

PaxDbiO49299.
PRIDEiO49299.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G23190.1; AT1G23190.1; AT1G23190.
GeneIDi838927.
GrameneiAT1G23190.1; AT1G23190.1; AT1G23190.
KEGGiath:AT1G23190.

Organism-specific databases

TAIRiAT1G23190.

Phylogenomic databases

eggNOGiKOG0625. Eukaryota.
COG0033. LUCA.
HOGENOMiHOG000009550.
InParanoidiO49299.
KOiK01835.
OMAiACKNREN.
OrthoDBiEOG0936067I.
PhylomeDBiO49299.

Enzyme and pathway databases

BioCyciARA:AT1G23190-MONOMER.
BRENDAi5.4.2.2. 399.
ReactomeiR-ATH-3322077. Glycogen synthesis.
R-ATH-70221. Glycogen breakdown (glycogenolysis).
R-ATH-70370. Galactose catabolism.

Miscellaneous databases

PROiO49299.

Gene expression databases

GenevisibleiO49299. AT.

Family and domain databases

Gene3Di3.30.310.50. 1 hit.
3.40.120.10. 3 hits.
InterProiIPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005845. A-D-PHexomutase_a/b/a-II.
IPR005846. A-D-PHexomutase_a/b/a-III.
IPR005843. A-D-PHexomutase_C.
IPR016066. A-D-PHexomutase_CS.
IPR005841. Alpha-D-phosphohexomutase_SF.
[Graphical view]
PfamiPF02878. PGM_PMM_I. 1 hit.
PF02879. PGM_PMM_II. 1 hit.
PF02880. PGM_PMM_III. 1 hit.
PF00408. PGM_PMM_IV. 1 hit.
[Graphical view]
PRINTSiPR00509. PGMPMM.
SUPFAMiSSF53738. SSF53738. 3 hits.
SSF55957. SSF55957. 1 hit.
PROSITEiPS00710. PGM_PMM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPGMC1_ARATH
AccessioniPrimary (citable) accession number: O49299
Secondary accession number(s): Q93Y04, Q9LR42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: February 8, 2011
Last modified: September 7, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.