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Protein

Endoglucanase 4

Gene

At1g23210

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei409 – 4091By similarity
Active sitei460 – 4601By similarity
Active sitei469 – 4691By similarity

GO - Molecular functioni

  1. cellulase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-KW
  2. cell wall organization Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cell wall biogenesis/degradation, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

BioCyciARA:AT1G23210-MONOMER.

Protein family/group databases

CAZyiGH9. Glycoside Hydrolase Family 9.

Names & Taxonomyi

Protein namesi
Recommended name:
Endoglucanase 4 (EC:3.2.1.4)
Alternative name(s):
Endo-1,4-beta glucanase 4
Gene namesi
Ordered Locus Names:At1g23210
ORF Names:F26F24.6, T26J12.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G23210.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 489464Endoglucanase 4PRO_0000249257Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi453 – 4531N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiO49296.

Expressioni

Gene expression databases

GenevestigatoriO49296.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G23210.1-P.

Structurei

3D structure databases

ProteinModelPortaliO49296.
SMRiO49296. Positions 28-489.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG299923.
HOGENOMiHOG000021033.
InParanoidiO49296.
OMAiENADNFI.
PhylomeDBiO49296.

Family and domain databases

Gene3Di1.50.10.10. 1 hit.
InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR012341. 6hp_glycosidase.
IPR001701. Glyco_hydro_9.
IPR018221. Glyco_hydro_9_AS.
[Graphical view]
PfamiPF00759. Glyco_hydro_9. 1 hit.
[Graphical view]
SUPFAMiSSF48208. SSF48208. 1 hit.
PROSITEiPS00592. GLYCOSYL_HYDROL_F9_1. 1 hit.
PS00698. GLYCOSYL_HYDROL_F9_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O49296-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGKSFMTPA IMLAMLLLIS PETYAGHDYR DALRKSILFF EGQRSGKLPP
60 70 80 90 100
DQRLKWRRDS ALRDGSSAGV DLTGGYYDAG DNVKFGFPMA FTTTMMSWSV
110 120 130 140 150
IDFGKTMGPE LENAVKAIKW GTDYLMKATQ IPDVVFVQVG DAYSDHNCWE
160 170 180 190 200
RPEDMDTLRT VYKIDKDHSG SEVAGETAAA LAAASIVFEK RDPVYSKMLL
210 220 230 240 250
DRATRVFAFA QKYRGAYSDS LYQAVCPFYC DFNGYEDELL WGAAWLHKAS
260 270 280 290 300
KKRVYREFIV KNQVILRAGD TIHEFGWDNK HAGINVLVSK MVLMGKAEYF
310 320 330 340 350
QSFKQNADEF ICSLLPGISH PQVQYSQGGL LVKSGGSNMQ HVTSLSFLLL
360 370 380 390 400
TYSNYLSHAN KVVPCGEFTA SPALLRQVAK RQVDYILGDN PMKMSYMVGY
410 420 430 440 450
GSRFPQKIHH RGSSVPSVVD HPDRIGCKDG SRYFFSNNPN PNLLIGAVVG
460 470 480
GPNITDDFPD SRPYFQLTEP TTYINAPLLG LLGYFSAHY
Length:489
Mass (Da):54,630
Last modified:June 1, 1998 - v1
Checksum:i9B46F1C3111C4D0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002311 Genomic DNA. Translation: AAC00616.1.
AC005292 Genomic DNA. Translation: AAF86995.1.
CP002684 Genomic DNA. Translation: AEE30357.1.
DQ056459 mRNA. Translation: AAY78616.1.
BT026379 mRNA. Translation: ABH04486.1.
PIRiE86366.
RefSeqiNP_173735.1. NM_102170.1.
UniGeneiAt.51731.

Genome annotation databases

EnsemblPlantsiAT1G23210.1; AT1G23210.1; AT1G23210.
GeneIDi838930.
KEGGiath:AT1G23210.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002311 Genomic DNA. Translation: AAC00616.1.
AC005292 Genomic DNA. Translation: AAF86995.1.
CP002684 Genomic DNA. Translation: AEE30357.1.
DQ056459 mRNA. Translation: AAY78616.1.
BT026379 mRNA. Translation: ABH04486.1.
PIRiE86366.
RefSeqiNP_173735.1. NM_102170.1.
UniGeneiAt.51731.

3D structure databases

ProteinModelPortaliO49296.
SMRiO49296. Positions 28-489.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G23210.1-P.

Protein family/group databases

CAZyiGH9. Glycoside Hydrolase Family 9.

Proteomic databases

PRIDEiO49296.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G23210.1; AT1G23210.1; AT1G23210.
GeneIDi838930.
KEGGiath:AT1G23210.

Organism-specific databases

TAIRiAT1G23210.

Phylogenomic databases

eggNOGiNOG299923.
HOGENOMiHOG000021033.
InParanoidiO49296.
OMAiENADNFI.
PhylomeDBiO49296.

Enzyme and pathway databases

BioCyciARA:AT1G23210-MONOMER.

Gene expression databases

GenevestigatoriO49296.

Family and domain databases

Gene3Di1.50.10.10. 1 hit.
InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR012341. 6hp_glycosidase.
IPR001701. Glyco_hydro_9.
IPR018221. Glyco_hydro_9_AS.
[Graphical view]
PfamiPF00759. Glyco_hydro_9. 1 hit.
[Graphical view]
SUPFAMiSSF48208. SSF48208. 1 hit.
PROSITEiPS00592. GLYCOSYL_HYDROL_F9_1. 1 hit.
PS00698. GLYCOSYL_HYDROL_F9_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W., Redman J.C., Wu H.C., Utterback T., Town C.D.
    Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Arabidopsis ORF clones."
    Quinitio C., Chen H., Kim C.J., Shinn P., Ecker J.R.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Phylogenetic analysis of the plant endo-beta-1,4-glucanase gene family."
    Libertini E., Li Y., McQueen-Mason S.J.
    J. Mol. Evol. 58:506-515(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY.

Entry informationi

Entry nameiGUN4_ARATH
AccessioniPrimary (citable) accession number: O49296
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: June 1, 1998
Last modified: January 7, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.