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O49293 (PER13_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Peroxidase 13
Short name=Atperox P13
EC=1.11.1.7
Gene names
Name:PER13
Synonyms:P13
Ordered Locus Names:At1g77100
ORF Names:F22K20.17
OrganismArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length319 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Removal of H2O2, oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.

Catalytic activity

2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

Cofactor

Binds 1 heme B (iron-protoporphyrin IX) group per subunit By similarity.

Binds 2 calcium ions per subunit By similarity.

Subcellular location

Secreted By similarity.

Miscellaneous

There are 73 peroxidase genes in A.thaliana.

Sequence similarities

Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.

Sequence caution

The sequence AAC00622.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Biological processHydrogen peroxide
   Cellular componentSecreted
   DomainSignal
   LigandCalcium
Heme
Iron
Metal-binding
   Molecular functionOxidoreductase
Peroxidase
   PTMDisulfide bond
Glycoprotein
Pyrrolidone carboxylic acid
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processhydrogen peroxide catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionheme binding

Inferred from electronic annotation. Source: InterPro

peroxidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 319297Peroxidase 13
PRO_0000023679

Sites

Active site641Proton acceptor By similarity
Metal binding651Calcium 1 By similarity
Metal binding681Calcium 1; via carbonyl oxygen By similarity
Metal binding701Calcium 1; via carbonyl oxygen By similarity
Metal binding721Calcium 1 By similarity
Metal binding741Calcium 1 By similarity
Metal binding1891Iron (heme axial ligand) By similarity
Metal binding1901Calcium 2 By similarity
Metal binding2351Calcium 2 By similarity
Metal binding2381Calcium 2 By similarity
Metal binding2431Calcium 2 By similarity
Binding site1581Substrate; via carbonyl oxygen By similarity
Site601Transition state stabilizer By similarity

Amino acid modifications

Modified residue231Pyrrolidone carboxylic acid By similarity
Glycosylation2801N-linked (GlcNAc...) Potential
Disulfide bond33 ↔ 111 By similarity
Disulfide bond66 ↔ 71 By similarity
Disulfide bond117 ↔ 315 By similarity
Disulfide bond196 ↔ 222 By similarity

Sequences

Sequence LengthMass (Da)Tools
O49293 [UniParc].

Last modified November 25, 2002. Version 2.
Checksum: C2EF9074D14B9786

FASTA31934,765
        10         20         30         40         50         60 
MITIALFLVL LYFHDQLGYS AAQLQFGFYS ETCPSAESIV RDVVQQAVTN DPGKAAVLLR 

        70         80         90        100        110        120 
LQFHDCFVEG CDGSILIKHG GNDDERFAAG NAGVAGFDVI DEAKSELERF CPGVVSCADI 

       130        140        150        160        170        180 
VALAARDAIA EAKGPFYEVP TGRRDGLIAN VDHAKNLPDV QDSINTLKSK FREKGLSDQD 

       190        200        210        220        230        240 
LVLLSAGAHT IGTTACFFVI PRLDAQDPTI NPEFFQILRS KCPQGGDVNV RIPLDWDSQF 

       250        260        270        280        290        300 
VFDNQIFQNI KNGRGVILSD SVLYQDNNMK KIIDSYLETN QSSKANFAAD FTKAMIKMGA 

       310 
IGVKIGAEGE IRRLCSATN

« Hide

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. expand/collapse author list , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
Nature 408:816-820(2000) [PubMed: 11130712] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]"Analysis and expression of the class III peroxidase large gene family in Arabidopsis thaliana."
Tognolli M., Penel C., Greppin H., Simon P.
Gene 288:129-138(2002) [PubMed: 12034502] [Abstract]
Cited for: GENE FAMILY ORGANIZATION, NOMENCLATURE.
Strain: cv. Columbia.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AC002291 Genomic DNA. Translation: AAC00622.1. Different initiation.
IPIIPI00541020.
PIRH96799.
RefSeqNP_177835.2. NM_106360.2.
UniGeneAt.52544.

3D structure databases

ProteinModelPortalO49293.
SMRO49293. Positions 23-319.
ModBaseSearch...

Protein family/group databases

PeroxiBase94. AtPrx13.

Proteomic databases

PRIDEO49293.
ProMEXO49293.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID844045.
GenomeReviewsGene locus AT1G77100 in contig CT485782_GR.
KEGGath:AT1G77100.
NMPDRfig|3702.1.peg.7249.

Organism-specific databases

GeneFarm1496. 61.
TAIRAt1g77100.

Phylogenomic databases

GeneTreeEPGT00070000028399.
HOGENOMHBG597790.
InParanoidO49293.
PhylomeDBO49293.
ProtClustDBCLSN2917915.

Gene expression databases

ArrayExpressO49293.
GenevestigatorO49293.

Family and domain databases

InterProIPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR000823. Peroxidase_pln.
IPR019794. Peroxidases_AS.
[Graphical view]
PfamPF00141. peroxidase. 1 hit.
[Graphical view]
PRINTSPR00458. PEROXIDASE.
PR00461. PLPEROXIDASE.
SUPFAMSSF48113. Peroxidase_super. 1 hit.
PROSITEPS00435. PEROXIDASE_1. False negative.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePER13_ARATH
AccessionPrimary (citable) accession number: O49293
Entry history
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: November 25, 2002
Last modified: December 14, 2011
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents