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Protein

Peroxidase 13

Gene

PER13

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Removal of H2O2, oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.

Catalytic activityi

2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • heme bPROSITE-ProRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.PROSITE-ProRule annotation
  • Ca2+PROSITE-ProRule annotationNote: Binds 2 calcium ions per subunit.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei60 – 601Transition state stabilizerPROSITE-ProRule annotation
Active sitei64 – 641Proton acceptorPROSITE-ProRule annotation
Metal bindingi65 – 651Calcium 1PROSITE-ProRule annotation
Metal bindingi68 – 681Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation
Metal bindingi70 – 701Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation
Metal bindingi72 – 721Calcium 1PROSITE-ProRule annotation
Metal bindingi74 – 741Calcium 1PROSITE-ProRule annotation
Binding sitei158 – 1581Substrate; via carbonyl oxygenPROSITE-ProRule annotation
Metal bindingi189 – 1891Iron (heme axial ligand)PROSITE-ProRule annotation
Metal bindingi190 – 1901Calcium 2PROSITE-ProRule annotation
Metal bindingi235 – 2351Calcium 2PROSITE-ProRule annotation
Metal bindingi238 – 2381Calcium 2PROSITE-ProRule annotation
Metal bindingi243 – 2431Calcium 2PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Calcium, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT1G77100-MONOMER.

Protein family/group databases

PeroxiBasei94. AtPrx13.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxidase 13 (EC:1.11.1.7)
Short name:
Atperox P13
Gene namesi
Name:PER13
Synonyms:P13
Ordered Locus Names:At1g77100
ORF Names:F22K20.17
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G77100.

Subcellular locationi

  • Secreted PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 319297Peroxidase 13PRO_0000023679Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 111PROSITE-ProRule annotation
Disulfide bondi66 ↔ 71PROSITE-ProRule annotation
Disulfide bondi117 ↔ 315PROSITE-ProRule annotation
Disulfide bondi196 ↔ 222PROSITE-ProRule annotation
Glycosylationi280 – 2801N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO49293.
PRIDEiO49293.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G77100.1.

Structurei

3D structure databases

ProteinModelPortaliO49293.
SMRiO49293. Positions 23-319.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JWV4. Eukaryota.
ENOG41104K2. LUCA.
HOGENOMiHOG000237556.
InParanoidiO49293.
KOiK00430.
PhylomeDBiO49293.

Family and domain databases

InterProiIPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR000823. Peroxidase_pln.
IPR019794. Peroxidases_AS.
[Graphical view]
PfamiPF00141. peroxidase. 1 hit.
[Graphical view]
PRINTSiPR00458. PEROXIDASE.
PR00461. PLPEROXIDASE.
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiPS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O49293-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITIALFLVL LYFHDQLGYS AAQLQFGFYS ETCPSAESIV RDVVQQAVTN
60 70 80 90 100
DPGKAAVLLR LQFHDCFVEG CDGSILIKHG GNDDERFAAG NAGVAGFDVI
110 120 130 140 150
DEAKSELERF CPGVVSCADI VALAARDAIA EAKGPFYEVP TGRRDGLIAN
160 170 180 190 200
VDHAKNLPDV QDSINTLKSK FREKGLSDQD LVLLSAGAHT IGTTACFFVI
210 220 230 240 250
PRLDAQDPTI NPEFFQILRS KCPQGGDVNV RIPLDWDSQF VFDNQIFQNI
260 270 280 290 300
KNGRGVILSD SVLYQDNNMK KIIDSYLETN QSSKANFAAD FTKAMIKMGA
310
IGVKIGAEGE IRRLCSATN
Length:319
Mass (Da):34,765
Last modified:November 25, 2002 - v2
Checksum:iC2EF9074D14B9786
GO

Sequence cautioni

The sequence AAC00622.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AEE35935.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002291 Genomic DNA. Translation: AAC00622.1. Different initiation.
CP002684 Genomic DNA. Translation: AEE35935.1. Different initiation.
PIRiH96799.
RefSeqiNP_177835.2. NM_106360.2.
UniGeneiAt.52544.

Genome annotation databases

EnsemblPlantsiAT1G77100.1; AT1G77100.1; AT1G77100.
GeneIDi844045.
GrameneiAT1G77100.1; AT1G77100.1; AT1G77100.
KEGGiath:AT1G77100.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002291 Genomic DNA. Translation: AAC00622.1. Different initiation.
CP002684 Genomic DNA. Translation: AEE35935.1. Different initiation.
PIRiH96799.
RefSeqiNP_177835.2. NM_106360.2.
UniGeneiAt.52544.

3D structure databases

ProteinModelPortaliO49293.
SMRiO49293. Positions 23-319.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G77100.1.

Protein family/group databases

PeroxiBasei94. AtPrx13.

Proteomic databases

PaxDbiO49293.
PRIDEiO49293.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G77100.1; AT1G77100.1; AT1G77100.
GeneIDi844045.
GrameneiAT1G77100.1; AT1G77100.1; AT1G77100.
KEGGiath:AT1G77100.

Organism-specific databases

TAIRiAT1G77100.

Phylogenomic databases

eggNOGiENOG410JWV4. Eukaryota.
ENOG41104K2. LUCA.
HOGENOMiHOG000237556.
InParanoidiO49293.
KOiK00430.
PhylomeDBiO49293.

Enzyme and pathway databases

BioCyciARA:AT1G77100-MONOMER.

Miscellaneous databases

PROiO49293.

Family and domain databases

InterProiIPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR000823. Peroxidase_pln.
IPR019794. Peroxidases_AS.
[Graphical view]
PfamiPF00141. peroxidase. 1 hit.
[Graphical view]
PRINTSiPR00458. PEROXIDASE.
PR00461. PLPEROXIDASE.
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiPS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Analysis and expression of the class III peroxidase large gene family in Arabidopsis thaliana."
    Tognolli M., Penel C., Greppin H., Simon P.
    Gene 288:129-138(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY ORGANIZATION, NOMENCLATURE.
    Strain: cv. Columbia.

Entry informationi

Entry nameiPER13_ARATH
AccessioniPrimary (citable) accession number: O49293
Secondary accession number(s): F4I5K6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: November 25, 2002
Last modified: June 8, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

There are 73 peroxidase genes in A.thaliana.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.