Reviewed, UniProtKB/Swiss-Prot O49293 (PER13_ARATH)

Names and origin

Protein names

Recommended name:
    Peroxidase 13
      Short name=Atperox P13
    EC=1.11.1.7

Gene names

Name:	PER13
Synonyms:	P13
Ordered Locus Names:	At1g77100
ORF Names:	F22K20.17

Organism

Arabidopsis thaliana (Mouse-ear cress) [Complete proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis

Protein attributes

Sequence length	319 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.
Catalytic activity	Donor + H(2)O(2) = oxidized donor + 2 H(2)O.
Cofactor	Binds 1 heme B (iron-protoporphyrin IX) group per subunit By similarity. Binds 2 calcium ions per subunit By similarity.
Subcellular location	SecretedBy similarity.
Miscellaneous	There are 73 peroxidase genes in A.thaliana.
Sequence similarities	Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.

Ontologies

Keywords
Biological process	Hydrogen peroxide
Cellular component	Secreted
Domain	Signal
Ligand	Calcium Heme Iron Metal-binding
Molecular function	Oxidoreductase Peroxidase
PTM	Glycoprotein Pyrrolidone carboxylic acid
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	hydrogen peroxide catabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW peroxidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 319	297	Peroxidase 13		PRO_0000023679
Sites
	Active site	64	1	Proton acceptor By similarity
	Metal binding	65	1	Calcium 1 By similarity
	Metal binding	68	1	Calcium 1; via carbonyl oxygen By similarity
	Metal binding	70	1	Calcium 1; via carbonyl oxygen By similarity
	Metal binding	72	1	Calcium 1 By similarity
	Metal binding	74	1	Calcium 1 By similarity
	Metal binding	189	1	Iron (heme axial ligand) By similarity
	Metal binding	190	1	Calcium 2 By similarity
	Metal binding	235	1	Calcium 2 By similarity
	Metal binding	238	1	Calcium 2 By similarity
	Metal binding	243	1	Calcium 2 By similarity
	Binding site	158	1	Substrate; via carbonyl oxygen By similarity
	Site	60	1	Transition state stabilizer By similarity
Amino acid modifications
	Modified residue	23	1	Pyrrolidone carboxylic acid By similarity
	Glycosylation	280	1	N-linked (GlcNAc...) Potential
	Disulfide bond	33 ↔ 111		By similarity
	Disulfide bond	66 ↔ 71		By similarity
	Disulfide bond	117 ↔ 315		By similarity
	Disulfide bond	196 ↔ 222		By similarity

Sequences

	Sequence		Length	Mass (Da)
	O49293-1 [UniParc]. Last modified November 25, 2002. Version 2. Checksum: C2EF9074D14B9786	FASTA	319	34,765
	10 20 30 40 50 60 MITIALFLVL LYFHDQLGYS AAQLQFGFYS ETCPSAESIV RDVVQQAVTN DPGKAAVLLR 70 80 90 100 110 120 LQFHDCFVEG CDGSILIKHG GNDDERFAAG NAGVAGFDVI DEAKSELERF CPGVVSCADI 130 140 150 160 170 180 VALAARDAIA EAKGPFYEVP TGRRDGLIAN VDHAKNLPDV QDSINTLKSK FREKGLSDQD 190 200 210 220 230 240 LVLLSAGAHT IGTTACFFVI PRLDAQDPTI NPEFFQILRS KCPQGGDVNV RIPLDWDSQF 250 260 270 280 290 300 VFDNQIFQNI KNGRGVILSD SVLYQDNNMK KIIDSYLETN QSSKANFAAD FTKAMIKMGA 310 IGVKIGAEGE IRRLCSATN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana." Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W. Nature 408:816-820(2000) [PubMed: 11130712] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	"Analysis and expression of the class III peroxidase large gene family in Arabidopsis thaliana." Tognolli M., Penel C., Greppin H., Simon P. Gene 288:129-138(2002) [PubMed: 12034502] [Abstract] Cited for: GENE FAMILY ORGANIZATION, NOMENCLATURE. Strain: cv. Columbia.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AC002291 Genomic DNA. Translation: AAC00622.1. Different initiation.
PIR	H96799.
UniGene	At.52544
3D structure databases
HSSP	HSSP built from PDB template 1QGJ based on UniProtKB Q39034.
ModBase	Search...
Protein family/group databases
PeroxiBase	94. AtPrx13.
Proteomic databases
ProMEX	O49293.
Genome annotation databases
GenomeReviews	Gene locus AT1G77100 in contig CT485782_GR.
NMPDR	fig|3702.1.peg.7249.
Organism-specific databases
GeneFarm	1496. 61.
TAIR	At1g77100.
Gene expression databases
ArrayExpress	O49293.
Family and domain databases
InterPro	IPR002016. Haem_peroxidase_pln/fun/bac. IPR000823. Peroxidase_pln. [Graphical view]
Pfam	PF00141. peroxidase. 1 hit. [Graphical view]
PRINTS	PR00458. PEROXIDASE. PR00461. PLPEROXIDASE.
PROSITE	PS00435. PEROXIDASE_1. False negative. PS00436. PEROXIDASE_2. 1 hit. PS50873. PEROXIDASE_4. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PER13_ARATH

Accession

Primary (citable) accession number: O49293

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 25, 2002
Last sequence update:	November 25, 2002
Last modified:	November 25, 2008
This is version 64 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)