ID   SKI15_ARATH             Reviewed;         374 AA.
AC   O49279;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   16-JUN-2009, entry version 60.
DE   RecName: Full=SKP1-interacting partner 15;
DE   AltName: Full=F-box only protein 3;
GN   Name=SKIP15; Synonyms=FBX3; OrderedLocusNames=At1g76920;
GN   ORFNames=F22K20.2;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons;
OC   rosids; eurosids II; Brassicales; Brassicaceae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   MEDLINE=21016719; PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S.,
RA   White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y.,
RA   Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W.,
RA   Chung M.K., Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K.,
RA   Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y.,
RA   Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L.,
RA   Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E.,
RA   Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B.,
RA   Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P.,
RA   Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A.,
RA   Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I.,
RA   Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D.,
RA   Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M.,
RA   Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M.,
RA   Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis
RT   thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   MEDLINE=22954850; PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J.,
RA   Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F.,
RA   Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.,
RA   Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J.,
RA   Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y.,
RA   Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P.,
RA   Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F.,
RA   Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M.,
RA   Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J.,
RA   Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T.,
RA   Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y.,
RA   Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   MEDLINE=20530940; PubMed=11077244; DOI=10.1016/S1360-1385(00)01769-6;
RA   Xiao W., Jang J.-C.;
RT   "F-box proteins in Arabidopsis.";
RL   Trends Plant Sci. 5:454-457(2000).
RN   [5]
RP   INTERACTION WITH SKP1A/ASK1; SKP1B/ASK2; ASK11 AND ASK13.
RX   PubMed=12169662; DOI=10.1073/pnas.162339999;
RA   Gagne J.M., Downes B.P., Shiu S.-H., Durski A.M., Vierstra R.D.;
RT   "The F-box subunit of the SCF E3 complex is encoded by a diverse
RT   superfamily of genes in Arabidopsis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:11519-11524(2002).
RN   [6]
RP   INTERACTION WITH SKPIB/ASK2.
RX   MEDLINE=22681510; PubMed=12795696;
RX   DOI=10.1046/j.1365-313X.2003.01768.x;
RA   Risseeuw E.P., Daskalchuk T.E., Banks T.W., Liu E., Cotelesage J.,
RA   Hellmann H., Estelle M., Somers D.E., Crosby W.L.;
RT   "Protein interaction analysis of SCF ubiquitin E3 ligase subunits from
RT   Arabidopsis.";
RL   Plant J. 34:753-767(2003).
CC   -!- FUNCTION: Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase
CC       complexes, which may mediate the ubiquitination and subsequent
CC       proteasomal degradation of target proteins (By similarity).
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Part of a SCF (ASK-cullin-F-box) protein ligase complex
CC       (By similarity). Interacts with SKP1A/ASK1, SKP1B/ASK2, ASK11 and
CC       ASK13.
CC   -!- INTERACTION:
CC       Q9SIN1:At2g42580; NbExp=1; IntAct=EBI-591174, EBI-2292882;
CC       O49484:AT4g34210; NbExp=2; IntAct=EBI-591174, EBI-401185;
CC       Q39255:SKP1A; NbExp=2; IntAct=EBI-591174, EBI-532357;
CC       Q9FHW7:SKP1B; NbExp=3; IntAct=EBI-591174, EBI-604076;
CC   -!- SUBCELLULAR LOCATION: Nucleus (By similarity).
CC   -!- DOMAIN: The F-box is necessary for the interaction with ASK
CC       proteins (By similarity).
CC   -!- SIMILARITY: Contains 1 F-box domain.
CC   -!- WEB RESOURCE: Name=PlantsUBQ; Note=A functional genomics database
CC       for the ubiquitin/26S proteasome proteolytic pathway in plants;
CC       URL="http://plantsubq.genomics.purdue.edu/";
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DR   EMBL; AC002291; AAC00632.1; -; Genomic_DNA.
DR   EMBL; AY065102; AAL38278.1; -; mRNA.
DR   EMBL; BT008455; AAP37814.1; -; mRNA.
DR   EMBL; AY085473; AAM62699.1; -; mRNA.
DR   IPI; IPI00535488; -.
DR   PIR; A96798; A96798.
DR   RefSeq; NP_565142.1; -.
DR   UniGene; At.21630; -.
DR   UniGene; At.67164; -.
DR   IntAct; O49279; 9.
DR   ProMEX; O49279; -.
DR   GeneID; 844027; -.
DR   GenomeReviews; CT485782_GR; AT1G76920.
DR   KEGG; ath:AT1G76920; -.
DR   NMPDR; fig|3702.1.peg.7224; -.
DR   TAIR; At1g76920; -.
DR   OMA; O49279; PWRSQWK.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0019941; P:modification-dependent protein catabolic pr...; IEA:UniProtKB-KW.
DR   InterPro; IPR001810; F-box.
DR   InterPro; IPR011498; Kelch_2.
DR   Pfam; PF00646; F-box; 1.
DR   Pfam; PF07646; Kelch_2; 2.
DR   SMART; SM00256; FBOX; 1.
DR   PROSITE; PS50181; FBOX; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Nucleus; Ubl conjugation pathway.
FT   CHAIN         1    374       SKP1-interacting partner 15.
FT                                /FTId=PRO_0000273536.
FT   DOMAIN        3     48       F-box.
SQ   SEQUENCE   374 AA;  42494 MW;  1D8584587C616173 CRC64;
     MESSPVNCLP PDSLHQIFSS LPIRDIMICR SVCKFFNQLL TSQCFIEIIS TRPPLNLLAL
     RPPHHHHSHR HSGNGHATNI RPYIHVYDPE QNQWFRFNLD FLPFRSPQPV ASSSGLIYLW
     GDSIDLAESS KSLVACNPLT RQFKVLPQLG SAWSRHGTVL VDSVNRVMVL TELAALYYSG
     TVVANQWLKF SSNLPSKPRS PVLMSSSVFA LCDVGSPWRS QWKLFSCKLT NLTITHTNWV
     CLEKHEWGDI FDIIKRPRLL RGNGDSKLLM IGGLKSTFSL NPACSTILIL RLDLESLEWE
     EAGRMPLEMY RGFQESSKFK VFGGGDRVYF SAKRMGKLAM WDCWQGWRWI EGVPGYADGL
     CRGFVFDAKL TLMP
//