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Protein

SKP1-interacting partner 15

Gene

SKIP15

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
SKP1-interacting partner 15
Alternative name(s):
F-box only protein 3
Gene namesi
Name:SKIP15
Synonyms:FBX3
Ordered Locus Names:At1g76920
ORF Names:F22K20.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G76920.
TAIRilocus:2025247. AT1G76920.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002735361 – 374SKP1-interacting partner 15Add BLAST374

Proteomic databases

PaxDbiO49279.

Expressioni

Gene expression databases

ExpressionAtlasiO49279. baseline and differential.
GenevisibleiO49279. AT.

Interactioni

Subunit structurei

Part of a SCF (ASK-cullin-F-box) protein ligase complex (By similarity). Interacts with SKP1A/ASK1, SKP1B/ASK2, ASK11 and ASK13.By similarity2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi29246. 12 interactors.
IntActiO49279. 12 interactors.
STRINGi3702.AT1G76920.1.

Structurei

3D structure databases

ProteinModelPortaliO49279.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 48F-boxPROSITE-ProRule annotationAdd BLAST46

Domaini

The F-box is necessary for the interaction with ASK proteins.By similarity

Phylogenomic databases

eggNOGiENOG410IH5I. Eukaryota.
ENOG410YBGK. LUCA.
HOGENOMiHOG000241138.
InParanoidiO49279.
OMAiHETLSHN.
OrthoDBiEOG09360D5M.
PhylomeDBiO49279.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiView protein in InterPro
IPR001810. F-box_dom.
IPR015916. Gal_Oxidase_b-propeller.
IPR011498. Kelch_2.
PfamiView protein in Pfam
PF00646. F-box. 1 hit.
PF07646. Kelch_2. 1 hit.
SMARTiView protein in SMART
SM00256. FBOX. 1 hit.
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiView protein in PROSITE
PS50181. FBOX. 1 hit.

Sequencei

Sequence statusi: Complete.

O49279-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESSPVNCLP PDSLHQIFSS LPIRDIMICR SVCKFFNQLL TSQCFIEIIS
60 70 80 90 100
TRPPLNLLAL RPPHHHHSHR HSGNGHATNI RPYIHVYDPE QNQWFRFNLD
110 120 130 140 150
FLPFRSPQPV ASSSGLIYLW GDSIDLAESS KSLVACNPLT RQFKVLPQLG
160 170 180 190 200
SAWSRHGTVL VDSVNRVMVL TELAALYYSG TVVANQWLKF SSNLPSKPRS
210 220 230 240 250
PVLMSSSVFA LCDVGSPWRS QWKLFSCKLT NLTITHTNWV CLEKHEWGDI
260 270 280 290 300
FDIIKRPRLL RGNGDSKLLM IGGLKSTFSL NPACSTILIL RLDLESLEWE
310 320 330 340 350
EAGRMPLEMY RGFQESSKFK VFGGGDRVYF SAKRMGKLAM WDCWQGWRWI
360 370
EGVPGYADGL CRGFVFDAKL TLMP
Length:374
Mass (Da):42,494
Last modified:June 1, 1998 - v1
Checksum:i1D8584587C616173
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002291 Genomic DNA. Translation: AAC00632.1.
CP002684 Genomic DNA. Translation: AEE35903.1.
AY065102 mRNA. Translation: AAL38278.1.
BT008455 mRNA. Translation: AAP37814.1.
AY085473 mRNA. Translation: AAM62699.1.
PIRiA96798.
RefSeqiNP_565142.1. NM_106343.4.
UniGeneiAt.21630.
At.67164.

Genome annotation databases

EnsemblPlantsiAT1G76920.1; AT1G76920.1; AT1G76920.
GeneIDi844027.
GrameneiAT1G76920.1; AT1G76920.1; AT1G76920.
KEGGiath:AT1G76920.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiSKI15_ARATH
AccessioniPrimary (citable) accession number: O49279
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: June 1, 1998
Last modified: June 7, 2017
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways