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Protein

SKP1-interacting partner 15

Gene

SKIP15

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
SKP1-interacting partner 15
Alternative name(s):
F-box only protein 3
Gene namesi
Name:SKIP15
Synonyms:FBX3
Ordered Locus Names:At1g76920
ORF Names:F22K20.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G76920
TAIRilocus:2025247 AT1G76920

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002735361 – 374SKP1-interacting partner 15Add BLAST374

Proteomic databases

PaxDbiO49279

Expressioni

Gene expression databases

ExpressionAtlasiO49279 baseline and differential
GenevisibleiO49279 AT

Interactioni

Subunit structurei

Part of a SCF (ASK-cullin-F-box) protein ligase complex (By similarity). Interacts with SKP1A/ASK1, SKP1B/ASK2, ASK11 and ASK13.By similarity2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi2924612 interactors.
IntActiO49279 12 interactors.
STRINGi3702.AT1G76920.1

Structurei

3D structure databases

ProteinModelPortaliO49279
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 48F-boxPROSITE-ProRule annotationAdd BLAST46

Domaini

The F-box is necessary for the interaction with ASK proteins.By similarity

Phylogenomic databases

eggNOGiENOG410IH5I Eukaryota
ENOG410YBGK LUCA
HOGENOMiHOG000241138
InParanoidiO49279
OMAiHETLSHN
OrthoDBiEOG09360D5M
PhylomeDBiO49279

Family and domain databases

Gene3Di2.120.10.801 hit
InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR015915 Kelch-typ_b-propeller
IPR011498 Kelch_2
PfamiView protein in Pfam
PF00646 F-box, 1 hit
PF07646 Kelch_2, 1 hit
SMARTiView protein in SMART
SM00256 FBOX, 1 hit
SUPFAMiSSF117281 SSF117281, 2 hits
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit

Sequencei

Sequence statusi: Complete.

O49279-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESSPVNCLP PDSLHQIFSS LPIRDIMICR SVCKFFNQLL TSQCFIEIIS
60 70 80 90 100
TRPPLNLLAL RPPHHHHSHR HSGNGHATNI RPYIHVYDPE QNQWFRFNLD
110 120 130 140 150
FLPFRSPQPV ASSSGLIYLW GDSIDLAESS KSLVACNPLT RQFKVLPQLG
160 170 180 190 200
SAWSRHGTVL VDSVNRVMVL TELAALYYSG TVVANQWLKF SSNLPSKPRS
210 220 230 240 250
PVLMSSSVFA LCDVGSPWRS QWKLFSCKLT NLTITHTNWV CLEKHEWGDI
260 270 280 290 300
FDIIKRPRLL RGNGDSKLLM IGGLKSTFSL NPACSTILIL RLDLESLEWE
310 320 330 340 350
EAGRMPLEMY RGFQESSKFK VFGGGDRVYF SAKRMGKLAM WDCWQGWRWI
360 370
EGVPGYADGL CRGFVFDAKL TLMP
Length:374
Mass (Da):42,494
Last modified:June 1, 1998 - v1
Checksum:i1D8584587C616173
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002291 Genomic DNA Translation: AAC00632.1
CP002684 Genomic DNA Translation: AEE35903.1
AY065102 mRNA Translation: AAL38278.1
BT008455 mRNA Translation: AAP37814.1
AY085473 mRNA Translation: AAM62699.1
PIRiA96798
RefSeqiNP_565142.1, NM_106343.4
UniGeneiAt.21630
At.67164

Genome annotation databases

EnsemblPlantsiAT1G76920.1; AT1G76920.1; AT1G76920
GeneIDi844027
GrameneiAT1G76920.1; AT1G76920.1; AT1G76920
KEGGiath:AT1G76920

Similar proteinsi

Entry informationi

Entry nameiSKI15_ARATH
AccessioniPrimary (citable) accession number: O49279
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: June 1, 1998
Last modified: April 25, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome