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O49279 (SKI15_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
SKP1-interacting partner 15
Alternative name(s):
F-box only protein 3
Gene names
Name:SKIP15
Synonyms:FBX3
Ordered Locus Names:At1g76920
ORF Names:F22K20.2
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonscore eudicotyledonsrosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length374 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins By similarity.

Pathway

Protein modification; protein ubiquitination.

Subunit structure

Part of a SCF (ASK-cullin-F-box) protein ligase complex By similarity. Interacts with SKP1A/ASK1, SKP1B/ASK2, ASK11 and ASK13. Ref.6 Ref.7

Subcellular location

Nucleus By similarity.

Domain

The F-box is necessary for the interaction with ASK proteins By similarity.

Sequence similarities

Contains 1 F-box domain.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   Cellular componentNucleus
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein ubiquitination

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 374374SKP1-interacting partner 15
PRO_0000273536

Regions

Domain3 – 4846F-box

Sequences

Sequence LengthMass (Da)Tools
O49279 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 1D8584587C616173

FASTA37442,494
        10         20         30         40         50         60 
MESSPVNCLP PDSLHQIFSS LPIRDIMICR SVCKFFNQLL TSQCFIEIIS TRPPLNLLAL 

        70         80         90        100        110        120 
RPPHHHHSHR HSGNGHATNI RPYIHVYDPE QNQWFRFNLD FLPFRSPQPV ASSSGLIYLW 

       130        140        150        160        170        180 
GDSIDLAESS KSLVACNPLT RQFKVLPQLG SAWSRHGTVL VDSVNRVMVL TELAALYYSG 

       190        200        210        220        230        240 
TVVANQWLKF SSNLPSKPRS PVLMSSSVFA LCDVGSPWRS QWKLFSCKLT NLTITHTNWV 

       250        260        270        280        290        300 
CLEKHEWGDI FDIIKRPRLL RGNGDSKLLM IGGLKSTFSL NPACSTILIL RLDLESLEWE 

       310        320        330        340        350        360 
EAGRMPLEMY RGFQESSKFK VFGGGDRVYF SAKRMGKLAM WDCWQGWRWI EGVPGYADGL 

       370 
CRGFVFDAKL TLMP 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. expand/collapse author list , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[4]"Full-length cDNA from Arabidopsis thaliana."
Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"F-box proteins in Arabidopsis."
Xiao W., Jang J.-C.
Trends Plant Sci. 5:454-457(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.
[6]"The F-box subunit of the SCF E3 complex is encoded by a diverse superfamily of genes in Arabidopsis."
Gagne J.M., Downes B.P., Shiu S.-H., Durski A.M., Vierstra R.D.
Proc. Natl. Acad. Sci. U.S.A. 99:11519-11524(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SKP1A/ASK1; SKP1B/ASK2; ASK11 AND ASK13.
[7]"Protein interaction analysis of SCF ubiquitin E3 ligase subunits from Arabidopsis."
Risseeuw E.P., Daskalchuk T.E., Banks T.W., Liu E., Cotelesage J., Hellmann H., Estelle M., Somers D.E., Crosby W.L.
Plant J. 34:753-767(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SKPIB/ASK2.
+Additional computationally mapped references.

Web resources

PlantsUBQ

A functional genomics database for the ubiquitin/26S proteasome proteolytic pathway in plants

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC002291 Genomic DNA. Translation: AAC00632.1.
CP002684 Genomic DNA. Translation: AEE35903.1.
AY065102 mRNA. Translation: AAL38278.1.
BT008455 mRNA. Translation: AAP37814.1.
AY085473 mRNA. Translation: AAM62699.1.
IPIIPI00535488.
PIRA96798.
RefSeqNP_565142.1. NM_106343.3.
UniGeneAt.21630.
At.67164.

3D structure databases

ProteinModelPortalO49279.
SMRO49279. Positions 6-44.
ModBaseSearch...

Protein-protein interaction databases

IntActO49279. 12 interactions.
STRING3702.AT1G76920.1-P.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT1G76920.1; AT1G76920.1; AT1G76920.
GeneID844027.
KEGGath:AT1G76920.

Organism-specific databases

TAIRAt1g76920.

Phylogenomic databases

eggNOGNOG324999.
HOGENOMHOG000241138.
InParanoidO49279.
OMAVGSPWRS.
PhylomeDBO49279.
ProtClustDBCLSN2689248.

Enzyme and pathway databases

UniPathwayUPA00143.

Gene expression databases

GenevestigatorO49279.

Family and domain databases

Gene3D2.120.10.80. 2 hits.
InterProIPR001810. F-box_dom_cyclin-like.
IPR015915. Kelch-typ_b-propeller.
IPR011498. Kelch_2.
[Graphical view]
PfamPF00646. F-box. 1 hit.
PF07646. Kelch_2. 1 hit.
[Graphical view]
SMARTSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMSSF81383. F-box_dom_Skp2-like. 1 hit.
PROSITEPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSKI15_ARATH
AccessionPrimary (citable) accession number: O49279
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: June 1, 1998
Last modified: May 1, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families